1-(2-苯并呋喃基)-2-丙酮 | 39581-52-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 中文名称: 1-(2-苯并呋喃基)-2-丙酮
• 英文名称: 2-Benzofurylaceton
• 英文别名: benzofuran-2-yl-propan-2-one；2-Acetonylbenzofuran；1-(1-benzofuran-2-yl)propan-2-one
• CAS: 39581-52-7
• 化学式: C₁₁H₁₀O₂
• 分子量: 174.199
• InChiKey: IQJDUGGHJYAOTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-苯并呋喃基)-2-丙酮 在 sodium cyanoborohydride 、 二乙胺 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 (2R)-1-(1-benzofuran-2-yl)-N-methylpropan-2-amine
  参考文献：
  名称：

  2-ETHYLAMINE SUBSTITUTED BENZOFURAN AND BENZOTHIOPHENE COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT

  摘要：

  Pharmaceutically active 2-ethylamine substituted benzofuran and benzothiophene compositions are provided for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes 2-ethylamine substituted benzofuran and benzothiophene compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.

  公开号：

  WO2024108179A2
• 作为产物：
  描述：

  苯并呋喃-2(3H)-酮 以46%的产率得到
  参考文献：
  名称：

  CHAN J. H.-T.; ELIX J. A.; FERGUSON B. A., AUSTRAL. J. CHEM. , 1975, 28, NO 5, 1097-1111

  摘要：

  DOI：

文献信息

• INHIBITORS OF MYOCARDIN-RELATED TRANSCRIPTION FACTOR AND SERUM RESPONSE FACTOR (MRTF/SRF)-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME
  申请人：THE REGENTS OF THE UNIVERSITY OF MICHIGAN

  公开号：US20160145251A1

  公开（公告）日：2016-05-26

  Disclosed herein are inhibitors of gene transcription mediated by myocardin-related transcription factor and serum response factor, or both myocardin-related transcription factor and serum response factor (“MRTF/SRF”), and methods for their use in treating or preventing cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and Formula (II), and pharmaceutically acceptable salts thereof: wherein the substituents are as described.

  本文披露了抑制由肌动蛋白相关转录因子和血清反应因子或肌动蛋白相关转录因子和血清反应因子（“MRTF / SRF”）介导的基因转录的抑制剂，以及它们在治疗或预防癌症和纤维化方面的使用方法。特别地，本文披露了公式（I）和公式（II）的化合物及其药学上可接受的盐：其中取代基如所述。
• Novel enantiomeric compounds for treatment of cardiac arrhythmias and methods of use
  申请人：Aryx Therapeutics

  公开号：EP1857450A1

  公开（公告）日：2007-11-21

  The subject invention pertains to novel enantiomerically pure compounds of the formula and compositions comprising the compounds, for the treatment of cardiac arrhythmias. The subject invention further concerns a method of making and purifying the compounds. The enantiomerically purified compounds and compositions of these compounds, exhibit unexpectedly distinct and advantageous characteristics, such as a markedly superior ability to reduce or inhibit ventricular premature beats, as compared to racemic mixtures of the compounds.

  本发明涉及新型对映体纯化合物，其式为 以及包含该化合物的组合物，用于治疗心律失常。本发明还涉及一种制造和纯化这些化合物的方法。与外消旋混合物相比，对映体纯化的化合物和由这些化合物组成的组合物表现出意想不到的独特优势特性，如明显优于外消旋混合物的降低或抑制室性早搏的能力。
• Rearrangements of some furan and banzofuran 1.5,-dienols
  作者：David Martin、Julie A. Wurster、Mary J. Boylan、Robert M. Borzilleri、Gregory T. Engel、Edward J. Welsh

  DOI：10.1016/s0040-4039(00)61342-4

  日期：1993.1

  Isomers of 1-(2-furyl)-methyl-3-buten-ols and their benzofuran analogs were studied for their oxy-Cope and anionic oxy-Cope reactivity.
• ENANTIOMERIC COMPOUNDS FOR TREATMENT OF CARDIAC ARRHYTHMIAS AND METHODS OF USE
  申请人：ARYx Therapeutics

  公开号：EP1222180B1

  公开（公告）日：2007-08-08
• [EN] NEW COMPOUNDS<br/>[FR] NOUVEAUX COMPOSES
  申请人：ASTRAZENECA AB

  公开号：WO2000076990A1

  公开（公告）日：2000-12-21

  The present invention relates to certain aminoalkyl substituted heterocyclic compounds of formula (I), and pharmaceutically acceptable salts thereof, which exhibit good analgesic properties and are particularly effective in the treatment of chronic pain.