1-(4-羟基苯基)-2-苯基丙烷-1-酮 | 724-87-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1-(4-羟基苯基)-2-苯基丙烷-1-酮
• 英文名称: 1-(4-hydroxy-phenyl)-2-phenyl-propan-1-one
• 英文别名: 1-(4-Hydroxy-phenyl)-2-phenyl-propan-1-on；4-Hydroxy-α-methyl-deoxybenzoin；4-Hydroxy-α-methyldeoxybenzoin；1-(4-Hydroxyphenyl)-2-phenylpropan-1-one
• CAS: 724-87-8
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: JTWHKHFDSOLQBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-羟基苯基)-2-苯基丙烷-1-酮 生成 1-[4-(3-Diethylamino-propoxy)-phenyl]-1-(4-methoxy-phenyl)-2-phenyl-propan-1-ol
  参考文献：
  名称：

  BE637389

  摘要：

  公开号：
• 作为产物：
  描述：

  2-苯基丙酸 在 二硫化碳 、 三氯化铝 、 氯化亚砜 作用下， 生成 1-(4-羟基苯基)-2-苯基丙烷-1-酮
  参考文献：
  名称：

  Bruzau, Annales de Chimie (Cachan, France), 1934, vol. <11> 1, p. 257,276

  摘要：

  DOI：

文献信息

• Photo-Fries Rearrangements of Phenyl Phenylacylates in Polyethylene Films. Comparison of Reactivity and Selectivity with 1-Naphthyl Phenylacylates
  作者：Weiqiang Gu、Richard G. Weiss

  DOI：10.1021/jo001455+

  日期：2001.3.1

  The fates and kinetics of recombination of singlet radical pairs generated by photolyses of three phenyl phenylacylates have been examined in unstretched and stretched polyethylene films. Comparisons with results from photolyses of analogous 1-naphthyl phenylacylates in the same media lead to the conclusions that (1) phenoxy is less reactive overall than 1-naphthoxy toward a common phenylacyl radical

  在未拉伸和拉伸的聚乙烯薄膜中，研究了由三苯基苯基酰化物的光解产生的单线自由基对的重组和动力学。与在相同介质中类似的1-萘基苯基酰化物的光解结果进行比较，得出以下结论：（1）苯氧基总体上不如1-萘氧基对一个常见的苯酰基自由基具有反应性，但（2）该自由基对所在的受约束的笼子对1-萘氧基/苯甲酰基对的运动施加更大的控制。在自由基对的形状和范德华体积，天然聚乙烯薄膜中位点的空隙体积以及芳氧基的电子性质的背景下讨论了这些观察的原因。
• Process for the preparation of omega-arylalkanoic acids
  申请人：Hoechst Celanese Corporation

  公开号：US05149866A1

  公开（公告）日：1992-09-22

  The present inventon pertains to a process for the preparation of omega-arylalkanoic acids of the genral formula R--Ar--R.sup.1 --COOH wherein R is hydrogen, hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, or aryl; wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl; and wherein Ar is an aryl group which can be further substituted with at least one of hydroxy, C.sub.1 -C.sub.8 alkyl, C.sub.1 -C.sub.8 alkoxy, aryl, halide, amino, or acetamido. The omega arylalkanoic acids of the given formula are prepared using catalysts which provide an improvement over the known Willgerodt-Kindler reaction. The present invention also pertains to methods for removing sulfur during the above-described process for the preparation of the omega-arylalkanoic acids.

  本发明涉及一种制备通式为R--Ar--R.sup.1 --COOH的ω-芳基脂肪酸的方法，其中R为氢、羟基、C.sub.1-C.sub.8烷基、C.sub.1-C.sub.8烷氧基或芳基；其中R.sup.1为C.sub.1-C.sub.4烷基；其中Ar为芳基基团，可以进一步取代至少一种羟基、C.sub.1-C.sub.8烷基、C.sub.1-C.sub.8烷氧基、芳基、卤素、氨基或乙酰胺基。使用催化剂制备给定公式的ω-芳基脂肪酸，该催化剂比已知的威尔格罗德-金德勒反应提供了改进。本发明还涉及上述制备ω-芳基脂肪酸的过程中去除硫的方法。
• Triphenylalkene derivatives
  申请人：Imperial Chemical Industries PLC

  公开号：US04623660A1

  公开（公告）日：1986-11-18

  The disclosure relates to 1-p-aminoalkoxy phenyl-1-p-hydroxyphenyl-2-phenylalk-1-ene derivatives, processes for their manufacture and pharmaceutical compositions containing them. The compounds possess anti-oestrogenic activity and are useful in the treatment of anovulatory infertility and the breast tumors. Representative of the compounds disclosed is 1-(p-.beta.-dimethylaminoethoxyphenyl)-trans-1-p-hydroxyphenyl-2-p-tolylbu t-1-ene.

  本公开涉及1-对氨基烷氧基苯基-1-对羟基苯基-2-苯基烷基-1-烯衍生物、其制造方法和含有它们的制药组合物。这些化合物具有抗雌激素活性，可用于治疗无排卵不孕和乳腺肿瘤。所披露的化合物代表是1-（p-β-二甲氨基乙氧基苯基）-反-1-对羟基苯基-2-p-甲苯基丁-1-烯。
• Triphenylalkene derivatives, process for their preparation and pharmaceutical compositions containing them
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0002097A1

  公开（公告）日：1979-05-30

  1-p-Aminoalkoxy phenyl-1-p-hydroxyphenyl-2-phe- nylalk-1-ene derivatives of the formula: R, = H, lower alkyl R2 = loweralkyl or R, and R2 forms a heterocyclic radical with the adjacent N-atom R3 = halogen or lower alkyl R4 = H, halogen, OH, lower alkyl or forms with the benzene ring a naphthyl radical n = 2,3,4,5,6 Possess anti-oestrogenic activity and are useful in the treatment of anovulatory infertility and of breast tumours. Representative of the compounds is I-(p-β-dimethylaminoethoxyphenyl)-trans-I-p-hydroxyphenyl-2-p-tolylbut-I-ene.

  式中的 1-对氨基烷氧基苯基-1-对羟基苯基-2-己基烷-1-烯衍生物： R, = H、低级烷基 R2 = 低级烷基或 R，且 R2 与相邻 N 原子形成杂环基 R3 = 卤素或低级烷基 R4 = H、卤素、OH、低级烷基或与苯环形成萘基 n = 2、3、4、5、6 具有抗雌激素活性，可用于治疗无排卵性不孕症和乳腺肿瘤。 其中具有代表性的化合物是 I-(p-β-二甲基氨基乙氧基苯基)-反式-I-对羟基苯基-2-对甲苯丁-I-烯。
• Process for the preparation of arylalkylamines and substituted arylalkylamines
  申请人：HOECHST CELANESE CORPORATION

  公开号：EP0491557A1

  公开（公告）日：1992-06-24

  Arylalkylamines (as the hydrochloride salt), e.g. tyramine hydrochloride, are prepared by hydrogenating substituted or unsubstituted aryl-α-oximinoalkyl ketones, e.g. p-hydroxyisonitroacetophenone, in either in an aqueous reaction medium comprising hydrochloric acid, essentially without the presence of a lower alkyl alcohol in said reaction medium, or in an aqueous reaction medium comprising water, hydrochloric acid, and a lower alkyl alcohol, wherein the alcohol comprises less than about 90% by volume of the reaction medium. A substituent on the aryl portion of the aryl-α-oximinoalkyl ketone must be on a position which activates the aromatic ring.

  芳基烷基胺（盐酸盐），例如酪胺盐酸盐，是通过氢化取代或未取代的芳基-α-氧亚氨基烷基酮，例如对羟基异硝基苯乙酮，或者在包含盐酸的水性反应介质中，在所述反应介质中基本上不存在低级烷基醇，或者在包含水、盐酸和低级烷基醇的水性反应介质中，其中醇占反应介质的体积比低于约 90%。芳基-α-氧亚氨基烷基酮的芳基部分上的取代基必须位于激活芳环的位置上。