棍掌碱 | 7224-66-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 棍掌碱
• 英文名称: Coryneine
• 英文别名: 2-(3,4-dihydroxyphenyl)ethyl-trimethylazanium
• CAS: 7224-66-0
• 化学式: C11H18NO2+
• 分子量: 196.27
• InChiKey: VDTBORSEFUUDTP-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Pharmaceutical use of compounds which bind to a mammalian "trace amine" receptor
  申请人：Oregon Health & Science University

  公开号：EP1568770A2

  公开（公告）日：2005-08-31

  The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.

  本发明涉及新型哺乳动物生物胺受体蛋白和编码此类蛋白的基因。本发明提供了体外筛选能与本发明的哺乳动物痕量胺受体蛋白结合的化合物的方法，并与已知的痕量胺受体激动剂和拮抗剂相比，进一步表征了这些化合物的结合特性及其功能后果。由此提供了改进的药理学筛选方法。
• Novel mammalian receptor genes and uses
  申请人：——

  公开号：US20040072187A1

  公开（公告）日：2004-04-15

  The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian trace amine receptor proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian trace amine receptor gene. Also provided are recombinant expression constructs capable of expressing the mammalian trace amine receptor genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian trace amine receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.

  本发明涉及新型哺乳动物生物胺受体蛋白和编码此类蛋白的基因。本发明的目的是分离和鉴定哺乳动物痕量胺受体蛋白。本发明特别提供了与哺乳动物痕量胺受体基因的大鼠和人类同源物相对应的 mRNA 的分离互补 DNA 拷贝。本发明还提供了重组表达构建体，这些构建体能够在转化的原核细胞和真核细胞培养物中表达本发明的哺乳动物痕量胺受体基因，以及合成其中编码的哺乳动物痕量胺受体蛋白的转化细胞培养物。本发明还提供了在体外筛选能与本发明的哺乳动物痕量胺受体蛋白结合的化合物的方法，以及与已知的痕量胺受体激动剂和拮抗剂相比，进一步鉴定这些化合物的结合特性及其功能后果的方法。由此提供了改进的药理学筛选方法。
• MAMMALIAN RECEPTOR GENES AND USES
  申请人：Oregon Health & Science University

  公开号：EP1319070A2

  公开（公告）日：2003-06-18
• PATTERN FORMING METHOD, ACTIVE LIGHT SENSITIVE OR RADIATION SENSITIVE RESIN COMPOSITION, RESIST FILM, METHOD FOR MANUFACTURING ELECTRONIC DEVICE, AND ELECTRONIC DEVICE
  申请人：FUJIFILM Corporation

  公开号：US20160041465A1

  公开（公告）日：2016-02-11

  The pattern forming method includes (1) forming a film using an active light sensitive or radiation sensitive resin composition, (2) exposing the film to active light or radiation, and (3) developing the exposed film using a developer including an organic solvent, in which the active light sensitive or radiation sensitive resin composition contains a resin (A) having a group which generates a polar group by being decomposed due to the action of an acid, the resin (A) has a phenolic hydroxyl group and/or a phenolic hydroxyl group protected with a group leaving due to the action of an acid, and the developer including the organic solvent contains an additive which forms at least one interaction of an ionic bond, a hydrogen bond, a chemical bond, and a dipole interaction, with the polar group.
• RESIST PATTERN-FORMING METHOD
  申请人：JSR CORPORATION

  公开号：US20170075224A1

  公开（公告）日：2017-03-16

  A resist pattern-forming method comprises applying a chemically amplified resist material on a substrate to form a resist film on the substrate. The resist film is patternwise exposed to a radioactive ray having a wavelength of no greater than 250 nm. The resist film patternwise exposed is floodwise exposed to a radioactive ray having a wavelength of greater than 250 nm. The resist film floodwise exposed is baked and developed with a developer solution comprising an organic solvent. The chemically amplified resist material comprises a component that is capable of generating a radiation-sensitive sensitizer and an acid upon an exposure. The component comprises: a radiation-sensitive sensitizer generating agent, and at least one of a radiation-sensitive acid-and-sensitizer generating agent and a radiation-sensitive acid generating agent. The radiation-sensitive sensitizer generating agent comprises a compound represented by formula (B).