Butyltrichlorosilane appears as a colorless liquid with a pungent odor. Flash point 126°F. Corrosive to metals and skin. Used to make various silicon containing compounds.
颜色/状态：
Colorless liquid
溶解度：
Soluble in ethyl ether, benzene, toluene, ethyl acetate
蒸汽密度：
6.4 (Air = 1)
分解：
Hydrogen chloride and phosgene gases may form; both are toxic and irritating.
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Silane, Chlorosilane, and Related Compounds/
Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Anticipate seizures and treat if necessary ... . Monitor for shock and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal (refer to ingestion protocol in Section Three ... . Cover skin burns with sterile dressings after decontamination ... . /Silane, Chlorosilane, and Related Compounds/
Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Early intubation at the first sign of upper airway obstruction may be necessary. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors if patient is hypotensive with a normal fluid volume. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Silane, Chlorosilane, and related compounds/
/SIGNS AND SYMPTOMS/ Acute inhalation exposure may result in sneezing, choking, laryngitis, dyspnea (shortness of breath), respiratory tract irritation, and chest pain. Higher exposure can cause pulmonary edema, a medical emergency that can be delayed for several hours. This can cause death. Bleeding of nose and gums, ulceration of the nasal and oral mucosa, pulmonary edema, chronic bronchitis, and pneumonia may also occur. If the eyes have come in contact with dimethyldichlorosilane, irritation, pain, swelling, corneal erosion, and blindness may result. Dermatitis (red, inflamed skin), severe burns, pain, and shock generally follow dermal exposure. Inhalation irritates mucous membranes. Severe gastrointestinal damage may occur. Vapors cause severe eye and lung injury. Upon short contact, second and third degree burns may occur. Signs and symptoms of acute ingestion of dimethyldichlorosilane may be severe and include increased salivation, intense thirst, difficulty swallowing, chills, pain, and shock. Oral, esophageal, and stomach burns are common. /Dimethyldichlorosilane/
Kinetic Resolution of Tertiary Propargylic Alcohols by Enantioselective Cu−H-Catalyzed Si−O Coupling
作者：Jan Seliger、Xichang Dong、Martin Oestreich
DOI：10.1002/anie.201813229
日期：2019.2.11
A broad range of tertiary propargylic alcohols were kinetically resolved by catalyst‐controlled enantioselective silylation. This non‐enzymatic kineticresolution is catalyzed by a Cu−H species and makes use of the commercially available precatalyst MesCu/(R,R)‐Ph‐BPE and a simple hydrosilane as the resolving reagent. Both alkyl,aryl‐ as well as dialkyl‐substituted propargylic alcohols participate
[EN] PROCESS FOR THE STEPWISE SYNTHESIS OF SILAHYDROCARBONS<br/>[FR] PROCÉDÉ DE SYNTHÈSE SÉQUENTIELLE DE SILAHYDROCARBURES
申请人：MOMENTIVE PERFORMANCE MAT INC
公开号：WO2021243137A1
公开（公告）日：2021-12-02
The invention relates to a process for the stepwise synthesis of silahydrocarbons bearing up to four different organyl substituents at the silicon atom, wherein the process includes at least one step a) of producing a bifunctional hydridochlorosilane by a redistribution reaction, selective chlorination of hydridosilanes with an ether/HCI reagent, or by selective chlorination of hydridosilanes with SiCI4, at least one step b) of submitting a bifunctional hydridochloromonosilane to a hydrosilylation reaction, at least one step c) of hydrogenation of a chloromonosilane, and a step d) in which a silahydrocarbon compound is obtained in a hydrosilylation reaction.
本发明涉及一种逐步合成在硅原子上带有最多四种不同有机基团取代的硅氢化物的过程，其中该过程包括至少以下步骤：a) 通过重分配反应、使用醚/HCI试剂对氢硅烷进行选择性氯化，或者通过使用四氯化硅对氢硅烷进行选择性氯化来制备双功能氢氯硅烷；至少一个步骤 b) 将双功能氢氯单硅烷进行氢硅化反应；至少一个步骤 c) 对氯代单硅烷进行氢化；以及步骤 d) 在氢硅化反应中获得硅氢化物化合物。
Nitroxide chemistry. Part X. Reactions of NN-bistrifluoromethyl-amino-oxyl with alkyltrihalogenosilanes and vinylsilanes; rearrangement of (1 -NN-bistrifluoromethylamino-oxyalkyl)silanes
作者：Robert N. Haszeldine、David J. Rogers、Anthony E. Tipping
DOI：10.1039/dt9760001056
日期：——
The reactions of the oxyl (CF3)2N·O˙ with various alkyltrichlorosilanes and alkyltrifluorosilanes show that the α position of the alkyl group is deactivated towards radical attack and the effect is more pronounced with alkyltrichlorosilanes. A novel rearrangement of type N·O·C·Si→N·C·O·Si occurs on heating (1-NN-bistrifluoromethyl-amino-oxyalkyl)silanes, and the ease of rearrangement is in the order
Rhodium‐Catalyzed Synthesis of Chiral Monohydrosilanes by Intramolecular C−H Functionalization of Dihydrosilanes
作者：Wenpeng Ma、Li‐Chuan Liu、Kun An、Tao He、Wei He
DOI：10.1002/anie.202013041
日期：2021.2.19
The preparation of chiral monohydrosilanes remains a rarely achieved goal. To this end a Rh‐catalyzed desymmetrization of dihydrosilanes by way of intramolecular C(sp2)−H functionalization under simple and mild conditions has now been developed. This method provides easy access to a broad range of chiral monohydrosilanes in good yields with excellent enantioselectivities (up to >99 % ee). The resulting
Direct synthesis of organodichlorosilanes by the reaction of metallic silicon, hydrogen chloride and alkene/alkyne and by the reaction of metallic silicon and alkyl chloride
作者：Masaki Okamoto、Satoshi Onodera、Yuji Yamamoto、Eiichi Suzuki、Yoshio Ono
DOI：10.1039/b007068h
日期：——
from silicon with alkyl chlorides, propyl and butyl chlorides. During the reaction the alkyl chloride is dehydrochlorinated over the surface of copper originating from the catalyst to afford hydrogen chloride and alkene. The hydrogen chloride formed participates in the formation of the silicon–hydrogen bond in alkyldichlorosilane, and the reaction of silicon, hydrogen chloride and alkene also causes
