Tec-IN-21

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: Tec-IN-21
• 英文别名: 1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[(6-chloro-1H-imidazo[4,5-b]pyridin-2-yl)sulfanyl]ethanone
• 化学式: C₁₆H₁₅ClN₄O₂S
• 分子量: 362.8
• InChiKey: NWKQXTCDEYJWDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Inhibitors of the unconventional secretion of fibroblast growth factor 2 (FGF2) by tumor cells and uses thereof
  申请人：Universität Heidelberg

  公开号：US10842793B2

  公开（公告）日：2020-11-24

  The present invention relates to compounds that have the capability of inhibiting the secretion of fibroblast growth factor 2 (FGF2) by tumor cells, as well as uses of said compound in medicine, in particular in the prevention and/or treatment of cancerous or inflammatory diseases.

  本发明涉及能够抑制肿瘤细胞分泌成纤维细胞生长因子 2（FGF2）的化合物，以及所述化合物在医学中的用途，特别是在预防和/或治疗癌症或炎症性疾病中的用途。
• Inhibitors of the Unconventional Secretion of Fibroblast Growth Factor 2 (FGF2) by Tumor Cells and Uses Thereof
  申请人：Universität Heidelberg

  公开号：US20190307752A1

  公开（公告）日：2019-10-10

  The present invention relates to compounds that have the capability of inhibiting the secretion of fibroblast growth factor 2 (FGF2) by tumor cells, as well as uses of said compound in medicine, in particular in the prevention and/or treatment of cancerous or inflammatory diseases.
• [EN] INHIBITORS OF THE UNCONVENTIONAL SECRETION OF FIBROBLAST GROWTH FACTOR 2 (FGF2) BY TUMOR CELLS AND USES THEREOF<br/>[FR] INHIBITEURS DE LA SÉCRÉTION NON CLASSIQUE DU FACTEUR DE CROISSANCE DES FIBROBLASTES 2 (FGF2) PAR DES CELLULES TUMORALES ET LEURS UTILISATIONS
  申请人：UNIVERSITÄT HEIDELBERG

  公开号：WO2017167429A1

  公开（公告）日：2017-10-05

  The present invention relates to compounds that have the capability of inhibiting the secretion of fibroblast growth factor 2 (FGF2) by tumor cells, as well as uses of said compound in medicine, in particular in the prevention and/or treatment of cancerous or inflammatory diseases.