1-异丙氧基萘 | 20009-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-异丙氧基萘
• 英文名称: 1-i-propoxylnaphthalene
• 英文别名: 1-isopropoxynaphthalene；isopropyl-[1]naphthyl ether；Isopropyl-[1]naphthyl-aether；1-Isopentyloxy-naphthalin；1-Isopropyloxy-naphthalin；isopropyl-1-naphthylether；1-propan-2-yloxynaphthalene
• CAS: 20009-27-2
• 化学式: C₁₃H₁₄O
• mdl: MFCD20390270
• 分子量: 186.254
• InChiKey: KFSRMUHHVMJRLZ-UHFFFAOYSA-N

物化性质

• 沸点：
  282.5 °C
• 密度：
  1.029±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-异丙氧基萘 在 cesium fluoroxysulphate 、 三氟化硼 作用下， 以 乙腈 为溶剂， 反应 0.83h， 生成 2,2-difluoro-1-oxo-1,2-dihydronaphthalene
  参考文献：
  名称：

  Fluorination with cesium fluoroxysulfate. Room temperature fluorination of benzene and naphthalene derivatives

  摘要：

  DOI：

  10.1021/jo00219a032
• 作为产物：
  描述：

  1-萘酚钠 、 2-溴丙烷 在 1,4-二氧六环 、 potassium iodide 作用下， 生成 1-异丙氧基萘
  参考文献：
  名称：

  Hydrogen Exchange of Phenols and Phenol Ethers with Deutero-alcohol¹

  摘要：

  DOI：

  10.1021/ja01186a006

文献信息

• Cross-Coupling of Aryl/Alkenyl Ethers with Aryl Grignard Reagents through Nickel-Catalyzed CO Activation
  作者：Lan-Gui Xie、Zhong-Xia Wang

  DOI：10.1002/chem.201003731

  日期：2011.4.26

  achieved through the cleavage of the sp2 CO bond of aryl/alkenyl ethers catalyzed by a nickel complex, and by using Grignard reagents as nucleophiles (see scheme). This method displays a broad substrate scope and leads to good to excellent yields of the aryl–aryl or alkenyl–aryl cross‐coupling products.

  一个C的形成 C键已通过sp。的裂解达到2 ç 由复合镍的O芳基/烯基醚催化键，并且通过使用格氏试剂亲核（参见方案）。该方法显示了广泛的底物范围，并导致芳基-芳基或烯基-芳基交叉偶联产物的良好良好收率。
• Exploiting Ancillary Ligation To Enable Nickel-Catalyzed C–O Cross-Couplings of Aryl Electrophiles with Aliphatic Alcohols
  作者：Preston M. MacQueen、Joseph P. Tassone、Carlos Diaz、Mark Stradiotto

  DOI：10.1021/jacs.8b01800

  日期：2018.4.18

  The use of (L)Ni( o-tolyl)Cl precatalysts (L = PAd-DalPhos or CyPAd-DalPhos) enables the C( sp2)-O cross-coupling of primary, secondary, or tertiary aliphatic alcohols with (hetero)aryl electrophiles, including unprecedented examples of such nickel-catalyzed transformations employing (hetero)aryl chlorides, sulfonates, and pivalates. In addition to offering a competitive alternative to palladium catalysis

  (L)Ni(o-tolyl)Cl 预催化剂（L = PAd-DalPhos 或 CyPAd-DalPhos）的使用使伯、仲或叔脂肪醇与（杂）芳基的 C(sp2)-O 交叉偶联亲电试剂，包括使用（杂）芳基氯化物、磺酸盐和新戊酸盐的这种镍催化转化的前所未有的例子。除了提供钯催化的有竞争力的替代方案外，这项工作还确立了利用辅助连接作为促进具有挑战性的镍催化 C(sp2)-O 交叉偶联的补充手段的可行性，而无需求助于贵金属光氧化还原催化方法。
• Metal ions and complexes in organic reactions. Part IX. Copper(I)-catalysed conversion of aryl halides into alkyl aryl ethers
  作者：R. G. R. Bacon、S. C. Rennison

  DOI：10.1039/j39690000312

  日期：——

  heterogeneous catalytic conditions, e.g., in solutions containing a suspension of copper(I) oxide, reaction could in some cases be diverted to nucleophilic sustitution (ArHal → ArOAlk) by operating with a substantially homogeneous liquid medium containing copper(I) salts as catalysts. In a suitably chosen reaction system, e.g., ArHal–NaOAlk–AlkOH–Cul–2,4,6-collidine, at ∼100–120°, high yields of ethers resulted

  而醇钠还原芳基卤化物（ArHal →多相催化条件下，ARH）例如，在含有悬浮液的铜溶液（我），氧化反应可以在某些情况下被转移到亲核sustitution（ArHal →由具有基本上操作ArOAlk）含有铜（I）盐作为催化剂的均质液体介质。在适当选择的反应系统中，例如，ArHal–NaOAlk–AlkOH–Cul–2,4,6-可力丁在约100–120°的温度下，从正常的一元链烷醇衍生而来的醇盐导致醚的高收率，但还原反应通常以其他类型醇中的醇盐为主。由单环或多环芳基溴化物或碘化物，包括含有Me，OMe或CO 2 H基团作为核取代基的甲基或乙基醚（约80–100％）制备，可以举例说明这一过程。当OH或NH 2为取代基时，收率较低（约35–50％），这可能是由于它们参与竞争反应，而当NO 2，CHO或COMe为取代基时则未获得醚。
• Selective and Efficient Direct Fluorination of Polycyclic Aromatic Hydrocarbons Using 1-Fluoro-4-hydroxy-1,4-diazoniabicyclo[2.2.2]octane Bis(tetrafluoroborate)
  作者：Stojan Stavber、Marko Zupan

  DOI：10.1246/cl.1996.1077

  日期：1996.12

  bis(tetrafluoroborate) (AccufluorTM NFTh) was effectively used for selective fluorination of polycyclic aromatics. Naphthalene was site-selectively fluorinated to 1-fluoronaphthalene, phenanthrene to 9-fluorophenanthrene, and pyrene to 1-fluoropyrene. In a series of substituted naphthalenes the regioselectivity and effectiveness of fluorination depended on the position and the nature of the substituents.

  一种新的NF氟化试剂1-氟-4-羟基-1,4-重氮二环[2.2.2]辛烷双（四氟硼酸盐）（AccufluorTM NFTh）有效地用于多环芳烃的选择性氟化。萘经位点选择性氟化为 1-氟萘，菲为 9-氟菲，芘为 1-氟芘。在一系列取代的萘中，氟化的区域选择性和有效性取决于取代基的位置和性质。
• Ether Compounds for Treatment of Complement Mediated Disorders
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20150239920A1

  公开（公告）日：2015-08-27

  Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R 12 or R 13 on the A group is an ether (R 32 ) are provided. The inhibitors described herein target factor D and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor D's ability to modulate the classical and lectin complement pathways. The inhibitors of factor D described herein are capable of reducing the excessive activation of complement, which has been linked to certain autoimmune, inflammatory, and neurodegenerative diseases, as well as ischemia-reperfusion injury and cancer.

  提供了有关制备抑制补体因子D的化合物、使用方法和制备过程，所述化合物包括具有式I的化合物，或其药用可接受的盐或组合物，其中A组上的R12或R13是醚（R32）。本文描述的抑制剂靶向因子D并在替代性补体途径的早期和关键点上抑制或调节补体级联，并减少因子D调节经典和凝集素补体途径的能力。本文描述的因子D抑制剂能够减少过度激活的补体，这与某些自身免疫、炎症和神经退行性疾病、缺血再灌注损伤和癌症有关。