1-氯-4-(2,2-二苯基乙基)苯 | 88382-66-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1-氯-4-(2,2-二苯基乙基)苯
• 英文名称: (2-(4-chlorophenyl)ethane-1,1-diyl)dibenzene
• 英文别名: 1-Chloro-4-(2,2-diphenyl-ethyl)-benzene；1,1'-[2-(4-Chlorophenyl)ethane-1,1-diyl]dibenzene；1-chloro-4-(2,2-diphenylethyl)benzene
• CAS: 88382-66-5
• 化学式: C₂₀H₁₇Cl
• 分子量: 292.808
• InChiKey: HZVMCIDKLNTCAF-UHFFFAOYSA-N

物化性质

• 沸点：
  370.6±11.0 °C(Predicted)
• 密度：
  1.131±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  二苯甲酮 在 正丁基锂 、 1,10-菲罗啉 、 sodium hydride 作用下， 以 四氢呋喃 、 正己烷 、 苯 为溶剂， 反应 19.0h， 生成 1-氯-4-(2,2-二苯基乙基)苯
  参考文献：
  名称：

  Transition‐Metal‐Free Intermolecular Hydrocarbonation of Styrenes Mediated by NaH/1,10‐Phenanthroline

  摘要：

  AbstractA transition‐metal‐free intermolecular coupling reaction of halocompounds with styrenes in the presence of NaH and 1,10‐phenanthroline was developed. This reaction afforded hydrocarbonated products with complete anti‐Markovnikov selectivity. The method allows the use of a wide range of halocompounds, including aryl and alkyl halides, and good functional group tolerance. Detailed mechanistic studies indicated that an anilide anion generated in situ by the NaH‐mediated reduction of 1,10‐phenanthroline works as an electron donor and a hydrogen source.

  DOI：

  10.1002/chem.202203143

文献信息

• Electron Transfer-Induced Coupling of Haloarenes to Styrenes and 1,1-Diphenylethenes Triggered by Diketopiperazines and Potassium tert-Butoxide
  作者：Eswararao Doni、Shengze Zhou、John Murphy

  DOI：10.3390/molecules20021755

  日期：——

  The coupling of haloarenes to styrenes and 1,1-diarylethenes has been achieved with potassium tert-butoxide in the presence of N,N'-dialkyldiketopiperazines. In contrast to previously reported reactions where phenanthroline has been used to mediate the reactions, the use of diketopiperazines can lead to either 1,1,2-triarylethenes or 1,1,2-triarylethanes, depending on the conditions used.

  已成功实现卤代芳烃与苯乙烯和1,1-二芳基乙烯的耦合，反应条件为存在N,N'-二烷基二酮哌嗪的氢氧化钾叔丁基。与之前使用苯并喹啉介导反应的报道不同，使用二酮哌嗪可以根据所用条件生成1,1,2-三芳基乙烯或1,1,2-三芳基乙烷。
• A simple N-heterocyclic carbene for the catalytic up-conversion of aldehydes into stoichiometric super electron donors
  作者：Nadhrata Assani、Ludivine Delfau、Preslav Smits、Sébastien Redon、Youssef Kabri、Eder Tomás-Mendivil、Patrice Vanelle、David Martin、Julie Broggi

  DOI：10.1039/d4sc04011b

  日期：——

  Catalytic amounts of 1,3-di(methyl)imidazole-2-ylidene, one of the simplest and most prototypical N-heterocyclic carbenes, can up-convert aldehydes into powerful stoichiometric sources of electrons (Super Electron Donors) for reductive transformations of iodoaryls (Ered < −2 V). In particular, the hydroarylation of 1,1′-diarylethylenes, which may require high temperatures and inherently generate stoichiometric

  催化量的 1,3-二（甲基）咪唑-2-亚基（最简单和最具原型的 N-杂环卡宾之一）可以将醛上转换为强大的化学计量电子源（超级电子供体），用于碘芳基的还原转化（ E红色< −2 V）。特别是，1,1'-二芳基乙烯的加氢芳基化可能需要高温并固有地产生化学计量量的氧化废物，但在室温下进行，同时形成作为氧化副产物的酯。
• Formation of 2-arylnaphthalenes from N-tosylated phenylalanine derivatives
  作者：Mi Ra Seong、Hyun Nam Song、Jae Nyoung Kim

  DOI：10.1016/s0040-4039(98)01507-x

  日期：1998.9

  N-Tosylated phenylalanine derivatives in benzene in the presence of sulfuric acid afforded 2-arylnaphthalene derivatives in moderate yields. The reaction might proceed via the corresponding decarbonylated N-tosylimine derivatives. Aldol type reaction of N-tosylimines followed by intramolecular Friedel-Crafts reaction and elimination of p-toluenesulfonamide gave 2-arylnaphthalenes. (C) 1998 Elsevier Science Ltd. All rights reserved.