氧化白藜芦醇-3'-O-Beta-D-吡喃葡萄糖苷 | 144525-40-6

• 物质功能分类: 医药中间体 - 吡喃类化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 氧化白藜芦醇-3'-O-Beta-D-吡喃葡萄糖苷
• 中文别名: 氧化白藜芦醇-3'-O-Β-D-吡喃葡萄糖苷
• 英文名称: oxyresveratrol 3'-O-β-D-glucopyranoside
• 英文别名: Oxyresveratrol 3'-O-beta-D-glucopyranoside；(2S,3R,4S,5S,6R)-2-[3-[(E)-2-(2,4-dihydroxyphenyl)ethenyl]-5-hydroxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 144525-40-6
• 化学式: C₂₀H₂₂O₉
• 分子量: 406.389
• InChiKey: GGQVPULXXVQLRT-CUYWLFDKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  160
• 氢给体数：
  7
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  桑皮苷A 在 almond β-glucosidase 作用下， 以 aq. phosphate buffer 为溶剂， 反应 2.0h， 生成 氧化白藜芦醇-3'-O-Beta-D-吡喃葡萄糖苷 、 oxyresveratrol-4'-O-β-D-glucopyranoside
  参考文献：
  名称：

  Enhancement of the Tyrosinase Inhibitory Activity of Mori Cortex Radicis Extract by Biotransformation UsingLeuconostoc paramesenteroidesPR

  摘要：

  Mori Cortex Radicis (MCR), the root bark of Morus alba L., consists of various phytochemicals and exhibits a strong inhibitory effect on tyrosinase. To enhance the tyrosinase inhibitory activity of MCR extract without further purification of bioactive compounds, whole MCR extract was biotransformed with crude enzyme extract from a selected lactic acid bacterium, Leuconostoc paramesenteroides PR (LP). Mulberroside A (MA), a major stilbene glucoside of MCR, contains two beta-glucosyl residues at the C3 and C4' positions of oxyresveratrol (OXY). The crude enzyme of LP hydrolyzed the two glycosidic bonds of MA effectively, and 97.1% of MA was biotransformed into OXY within 2 h. Commercial almond beta-glucosidase hydrolyzed only one site of the two glycosidic bonds of MA, and 68.7% of MA was biotransformed to OXY-glucoside. The tyrosinase inhibitory activity of the crude extract of MCR was increased approximately 6.5-fold by biotransformation using LP, and the IC50 value of the transformed MCR was 3.7 mu g/mL.

  DOI：

  10.1271/bbb.111002

文献信息

• [EN] COMPOSITION COMPRISING A MORUS ALBA EXTRACT, AND ITS COSMETIC USES<br/>[FR] COMPOSITION COMPRENANT UN EXTRAIT DE MORUS ALBA ET SES UTILISATIONS COSMÉTIQUES
  申请人：OREAL

  公开号：WO2020201432A1

  公开（公告）日：2020-10-08

  The present invention relates to a composition comprising, in a physiologically acceptable medium, at least mulberroside A and mulberroside E. It also relates to cosmetic uses of said composition, especially for depigmenting, lightening and/or bleaching keratin materials, in particular the skin.