1-环庚烯-1-胺 | 75078-82-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 1-环庚烯-1-胺
• 中文别名: 环丙羧酸,2-氟-,丙基酯,(1R-顺)-(9CI)
• 英文名称: 1-Amino-cyclohepten-(1)
• 英文别名: 1-Cyclohepten-1-amine；cyclohepten-1-amine
• CAS: 75078-82-9
• 化学式: C₇H₁₃N
• mdl: MFCD18806721
• 分子量: 111.187
• InChiKey: LBOGZEQDXVHCJL-UHFFFAOYSA-N

物化性质

• 沸点：
  185.3±10.0 °C(Predicted)
• 密度：
  0.903±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.714
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
  申请人：3-Dimensional Pharmaceuticals, Inc.

  公开号：US20030105111A1

  公开（公告）日：2003-06-05

  The present invention is directed to a compound of Formula I: 1 wherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

  本发明涉及一种具有以下结构的化合物：其中A、R1和R2在此处被定义。本发明还涉及包含Formula I化合物的组合物、使用Formula I化合物的方法以及制备Formula I化合物的方法。
• Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1388342A1

  公开（公告）日：2004-02-11

  The present invention relates to acylated, heteroaryl-condensed cycloalkenylamines of the formula I, in which A, R1, R2, R3, R4, R5 and n have the meanings indicated in the claims. The compounds of formula I are valuable pharmacologically active compounds which are useful in the treatment of various disease states including cardiovascular disorders such as atherosclerosis, thrombosis, coronary artery disease, hypertension and cardiac insufficiency. They upregulate the expression of the enzyme endothelial nitric oxide (NO) synthase and can be applied in conditions in which an increased expression of said enzyme or an increased NO level or the normalization of a decreased NO level is desired. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

  本发明涉及公式I的酰化的异杂环缩合环烯基胺，其中A，R1，R2，R3，R4，R5和n具有声明中指定的含义。公式I的化合物是有价值的药理活性化合物，可用于治疗各种疾病状态，包括心血管疾病，如动脉粥样硬化，血栓形成，冠状动脉疾病，高血压和心脏衰竭。它们升调内皮一氧化氮（NO）合酶的表达，并可应用于需要增加该酶的表达或增加NO水平或恢复降低的NO水平的情况。本发明还涉及公式I化合物的制备方法，它们的使用，特别是作为药物中的活性成分，以及包含它们的制药制剂。
• 2,2,6,6-Tetramethyl-4-piperidyl carboxylic acid esters and amides of mono and poly alcohols, phenols and amines and synthetic polymer compositions stabilized thereby
  申请人：ADEKA ARGUS CHEMICAL CO., Ltd.

  公开号：EP0022997A1

  公开（公告）日：1981-01-28

  2,2,6,6-Tetramethyl-4-piperidyl carboxylic acid esters and amides of mono and poly alcohols, phenols and amines are provided, useful as stabilizers for organic polymeric materials, and having the general formula: wherein: R1, R2 and R3 are selected from the group consisting of hydrogen and alkyl having from one to about eighteen carbon atoms; X is oxygen or imino >NH; m is zero, 1 or 2; n is zero, 1 or 2; m + n is 1 or 2; p is zero or 1; q is 1 to 6; is linked to carbon in place of one R2 or R, group; and is selected from the group consisting of: (a) OR5 where R5 is alkyl, aryl or cycloalkyl having one to twenty-four carbon atoms and hydroxy-, carboxy- and oxy-substituted such groups having from one to five OH or O groups; and 2,2,6,6-tetramethyl-4-piperidyl; (b) OReO where Re is alkylene, arylene or cycloalkylene having one to twenty-four carbon atoms and hydroxy-substituted such groups having one to four OH groups; Re alkylene, aryiene or cycloalkylene can include oxyether -0- and thioether -S- linking groups attached to alkylene, arylene or cycloalkylene groups as in polyoxyalkylene and polythioalkylene groups and polyoxyalkylene arylene groups having from one to about five oxy or thio groups and from two to about six alkylene groups having (c) from two to about six carbon atoms; where R6 is alkylene, arylene or cycloalkylene having one to twenty-four carbon atoms and hydroxy-substituted such groups having one to four OH groups; R6 alkylene, arylene or cycloalkylene can include oxyether -O- and thioether -S- linking groups attached to alkylene, arylene or cycloalkylene groups as in polyoxyalkylene and polythioalkylene groups and polyoxyalkylene arylene groups having from one to about five oxy or thio groups and from two to about six alkylene groups having from two to about six carbon atoms; R7 is alkyl, aryl or cycloalkyl having one to twenty-four carbon atoms and hydroxy-substituted such groups having from one to five OH groups; (d) where R5 is alkyl, aryl or cycloalkyl having one to twenty-four carbon atoms and amino-substituted such groups having (e) from one to five amino groups; where R6 is alkylene, arylene or cycloalkylene having one to twenty-four carbon atoms and amino-substituted such groups having one to four amino groups; R7 is alkyl, aryl or cycloalkyl having one to twenty-four carbon atoms and amino-substituted such groups having one to five amino groups; (f)-NHNH2; -NHNH-; -NHNHCOCONHNH2; NHNHCOR7; -NHNHCOR6CONHNH2; -NHNHCOR6CONHNH-; -NHNHCOCONHNH-,; -NHR6NH2-; -NHR6NH-; where Rs is alkylene, arylene or cycloalkylene having one to twenty-four carbon atoms and amino-substituted such groups having one to four amino groups; and such groups including oxyether and thioether linking groups as in (b) above, and R7 is as in (c) above.

  本发明提供了 2,2,6,6-四甲基-4-哌啶基羧酸酯和一元醇和多元醇、酚和胺的酰胺，可用作有机聚合物材料的稳定剂，其通式为 其中 R1、R2 和 R3 选自氢和具有 1 至约 18 个碳原子的烷基组成的组； X 是氧或亚胺 >NH； m 为零、1 或 2 n 为零、1 或 2 m + n 为 1 或 2； p 为 0 或 1 q 为 1 至 6； 与碳相连，代替一个 R2 或 R, 基团；以及 选自以下组成的组 (a) OR5，其中 R5 是具有 1 至 24 个碳原子的烷基、芳基或环烷基，以及具有 1 至 5 个 OH 或 O 基团的羟基、羧基和氧基取代的此类基团；以及 2,2,6,6-四甲基-4-哌啶基； (b) OReO 其中 Re 为具有 1 至 24 个碳原子的亚烷基、芳基或环烷基，以及具有 1 至 4 个 OH 基团的羟基取代的此类基团；Re亚烷基、芳基或环烷基可包括连接到亚烷基、芳基或环烷基上的氧醚 -0- 和硫醚 -S- 连接基团，如聚氧亚烷基、聚硫亚烷基和聚氧亚烷基芳基中的氧醚 -0- 和硫醚 -S- 连接基团，这些基团具有 1 至 5 个氧基或硫代基团和 2 至 6 个亚烷基，这些亚烷基具有 (c) R6是具有一至二十四个碳原子的亚烷基、芳基或环烷基，以及具有一至四个羟基的羟基取代的亚烷基、芳基或环烷基；R6 亚烷基、亚芳基或环烷基可包括连接到亚烷基、亚芳基或环烷基上的氧醚 -O- 和硫醚 -S- 连接基团，如聚氧亚烷基和聚硫亚烷基以及聚氧亚烷基亚芳基中的氧醚 -O- 和硫醚 -S- 连接基团，这些亚烷基、亚芳基或环烷基具有一至约五个氧或硫基和二至约六个亚烷基，这些亚烷基具有二至约六个碳原子；R7 是具有一至二十四个碳原子的烷基、芳基或环烷基，以及具有一至五个羟基的羟基取代的此类基团； (d) 其中 R5 是具有一至二十四个碳原子的烷基、芳基或环烷基和具有 (e) R6 是具有 1 至 24 个碳原子的亚烷基、芳基或环烷基，以及具有 1 至 4 个氨基的氨基取代的此类基团；(f)-NHNH2; -NHNH-; -NHNHCOCONHNH2; NHNHCOR7; -NHNHCOR6CONHNH2; -NHNHCOR6CONHNH-; -NHNHCOCONHNH-,; -NHR6NH2-;-NHR6NH-； 其中 Rs 是具有一至二十四个碳原子的亚烷基、芳烯基或环烷基，以及具有一至四个氨基的氨基取代的此类基团；此类基团包括如上文(b)所述的氧醚和硫醚连接基团，R7 如上文(c)所述。
• A soil-disease-controlling agent
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0128006A2

  公开（公告）日：1984-12-12

  A soil disease controlling agent for preventing and controlling diseases caused by pathogenic fungi living in soil, which comprises an effective amount of at least one of a 2-cycloalkenylamine derivative and its salts as an active ingredient, and at least one inert carrier or diluent.

  一种用于预防和控制由生活在土壤中的病原真菌引起的病害的土壤病害控制剂，它包括有效量的至少一种 2-环烯胺衍生物及其盐类作为活性成分，以及至少一种惰性载体或稀释剂。
• NON-METALLOCENE, VERFAHREN ZUR HERSTELLUNG VON DIESEN UND DEREN VERWENDUNG ZUR POLYMERISATION VON OLEFINEN
  申请人：Basell Polyolefine GmbH

  公开号：EP1334107A2

  公开（公告）日：2003-08-13