1-甲基-4-[2-(4-甲基苯基)-1,2-二苯基乙基]苯 | 88689-63-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 1-甲基-4-[2-(4-甲基苯基)-1,2-二苯基乙基]苯
• 英文名称: 1,2-diphenyl-1,2-di-p-tolylethane
• 英文别名: Benzene, 1,1'-(1,2-diphenyl-1,2-ethanediyl)bis[4-methyl-；1-methyl-4-[2-(4-methylphenyl)-1,2-diphenylethyl]benzene
• CAS: 88689-63-8
• 化学式: C₂₈H₂₆
• 分子量: 362.514
• InChiKey: ZZZBPKUYEXHHAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  4-甲基二苯甲酮 在 tris(triphenylphosphine)ruthenium(II) chloride 盐酸 、 氢气 作用下， 以 xylene 为溶剂， 180.0 ℃ 、1.47 MPa 条件下， 反应 24.0h， 以15%的产率得到1-甲基-4-[2-(4-甲基苯基)-1,2-二苯基乙基]苯
  参考文献：
  名称：

  Ruthenium-Catalyzed Coupling Reaction of Benzylic Halides

  摘要：

  Reported herein is a novel method on dechlorination coupling reaction of halides by using RuCl2(PPh3)(3) catalyst under a hydrogen atmosphere with benzene as the solvent, which affords alkanes in excellent yields.

  DOI：

  10.1081/scc-120024745

文献信息

• Synthesis of Dibenzyls by Nickel-Catalyzed Homocoupling of Benzyl Alcohols
  作者：Xing-Zhong Shu、Feng-Feng Pan、Peng Guo、Xiaochuang Huang

  DOI：10.1055/a-1467-2432

  日期：2021.9

  blocks that are widely used in organic synthesis, and they are typically prepared by the homocoupling of halides, organometallics, and ethers. Herein, we report an approach to this class of compounds using alcohols, which are more stable and readily available. The reaction proceeds via nickel-catalyzed and dimethyl oxalate assisted dynamic kinetic homocoupling of benzyl alcohols. Both primary and secondary

  二苄基是广泛用于有机合成中的基本结构单元，它们通常通过卤化物，有机金属和醚的均偶联来制备。本文中，我们报告了一种使用醇的这类化合物的方法，该醇更稳定且易于获得。该反应通过镍催化的和草酸二甲酯辅助的苄醇的动态动力学均偶联进行。伯醇和仲醇都是可以容忍的。
• Palladium-Catalyzed Reaction of 2-Hydroxy-2-methylpropiophenone with Aryl Bromides:  A Unique Multiple Arylation via Successive C−C and C−H Bond Cleavages
  作者：Hiroyuki Wakui、Satoshi Kawasaki、Tetsuya Satoh、Masahiro Miura、Masakatsu Nomura

  DOI：10.1021/ja0477874

  日期：2004.7.1

  2-Hydroxy-2-methylpropiophenone undergoes a unique multiple arylation via C-C and C-H bond cleavages upon treatment with excess aryl bromides in the presence of a palladium catalyst to give 1,1,2,2-tetraarylethanes and 4,4-diaryl-1-phenylisochroman-3-ones.

  2-Hydroxy-2-methylpropiophenone 在钯催化剂存在下用过量的芳基溴化物处理后，通过 CC 和 CH 键裂解发生独特的多重芳基化，得到 1,1,2,2-四芳基乙烷和 4,4-二芳基-1 -phenylisochroman-3-ones。
• Ruthenium-catalyzed carbon–carbon formation to synthesize tetraarylethanes and tetraarylxylylene through dechlorinative dimeric reaction
  作者：Yanjun Li、Tatsuro Kijima、Taeko Izumi

  DOI：10.1016/j.jorganchem.2003.08.019

  日期：2003.12

  Dechlorinative coupling-dimerization reaction is studied to synthesize alkanes by using tris-triphenylphosphine ruthenium (II) in the presence of hydrogen atmosphere. Two types of halides (alpha-chlorodiarylmethanes 1a-d and bis(chlorophenylmethyl)-1,3-phenylene 6) are employed as substrates to form radical species and then dimerized to generate alkanes in high yields. To our knowledge, it is the first time that the formation of 1,1,2,2-tetraarylethanes and 1,2,9,10-tetraphenyl-di-m-xylylene over typical ruthenium-catalyzed dehalogenative coupling-dimerization conditions is reported. (C) 2003 Elsevier B.V. All rights reserved.
• Thoerner, Justus Liebigs Annalen der Chemie, 1877, vol. 189, p. 84
  作者：Thoerner

  DOI：——

  日期：——
• Thoerner; Zincke, Chemische Berichte, 1878, vol. 11, p. 70
  作者：Thoerner、Zincke

  DOI：——

  日期：——