1-羟基-2-萘-N-甲基羧胺 | 62353-81-5

• 物质功能分类: 化学试剂 - 有机试剂 - 多环化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-羟基-2-萘-N-甲基羧胺
• 中文别名: 1-羟基-N-2-萘甲酰胺
• 英文名称: 2-Methylcarbamoyl-naphth-1-ol
• 英文别名: 1-hydroxy-naphthalene-2-carboxylic acid methylamide；2-Naphthalenecarboxamide, 1-hydroxy-N-methyl-；1-hydroxy-N-methylnaphthalene-2-carboxamide
• CAS: 62353-81-5
• 化学式: C₁₂H₁₁NO₂
• mdl: MFCD11130731
• 分子量: 201.225
• InChiKey: YEOGSEYGVSFBHS-UHFFFAOYSA-N

物化性质

• 沸点：
  440.0±28.0 °C(Predicted)
• 密度：
  1.239±0.06 g/cm3(Predicted)
• 物理描述：
  DryPowder

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.083
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险性防范说明：
  P264,P280,P302+P352,P337+P313,P305+P351+P338,P362+P364,P332+P313
• 危险性描述：
  H315,H319

反应信息

• 作为反应物：
  描述：

  1-羟基-2-萘-N-甲基羧胺 在 溴 作用下， 以 1,4-二氧六环 为溶剂， 以85%的产率得到1-hydroxy-4-bromo-2-naphthoic acid N-methylamide
  参考文献：
  名称：

  Movchan; Ziganshina; Akhmetov, Russian Journal of Organic Chemistry, 1998, vol. 34, # 4, p. 502 - 509

  摘要：

  DOI：

文献信息

• Inhibitors of interleukin-1ß converting enzyme
  申请人：Vertex Pharmceuticals Incorporated

  公开号：EP2083014A2

  公开（公告）日：2009-07-29

  The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physiochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against IL-1-, apoptosis-, IGIF-, and IFN-γ-mediated diseases, inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, infectious diseases, degenerative diseases, and necrotic diseases. This invention also relates to methods for inhibiting ICE activity, for treating interleukin-1-, apoptosis-, IGIF-, and IFN-γ-mediated diseases and decreasing IGIF, and IFN-γ production using the compounds and compositions of this invention. This invention also relates to methods for preparing N-acylamino compounds.

  本发明涉及一类新型化合物，它们是白细胞介素-1β转换酶的抑制剂。本发明的 ICE 抑制剂具有特定的结构和理化特征。本发明还涉及包含这些化合物的药物组合物。本发明的化合物和药物组合物特别适用于抑制 ICE 的活性，因此可作为抗 IL-1、细胞凋亡、IGIF 和 IFN-γ 介导的疾病、炎症性疾病、自身免疫性疾病、破坏性骨疾病、增殖性疾病、感染性疾病、退行性疾病和坏死性疾病的药物。本发明还涉及使用本发明化合物和组合物抑制 ICE 活性、治疗白细胞介素-1、细胞凋亡、IGIF 和 IFN-γ 介导的疾病以及减少 IGIF 和 IFN-γ 生成的方法。本发明还涉及制备 N-酰氨基化合物的方法。
• Electroluminescence device, cyclic azine compound and production process of cyclic azine dye
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：US20020102435A1

  公开（公告）日：2002-08-01

  Disclosed are an organic electroluminescence device comprising at least one organic thin film between electrodes, which contains at least one compound represented by formula (1), (2) or (3); a cyclic azine compound having a structure represented by formula (4); a process for producing a cyclic azine dye represented by formula (15), comprising reacting a phenylenediamine derivative represented by formula (13) with a phenol derivative represented by formula (14) in the presence of an oxidizing agent in an alkaline atmosphere; a process for producing a cyclic azine dye represented by formula (18), comprising oxidation reacting an aniline derivative represented by formula (16) or (17) by an oxidizing agent in an alkaline atmosphere; and a process for producing a cyclic azine dye represented by formula (3), comprising reacting a carbonyl compound derivative represented by formula (19) with an aniline compound derivative represented by formula (20) or a salt thereof in the presence of an oxidizing agent in an alkaline atmosphere.

  本发明公开了一种有机电致发光装置，该装置包括电极之间的至少一层有机薄膜，该薄膜含有至少一种由式(1)、(2)或(3)表示的化合物；一种具有由式(4)表示的结构的环偶氮化合物；一种生产由式(15)表示的环偶氮染料的工艺，该工艺包括在碱性气氛中，在氧化剂存在下，由式(13)表示的苯二胺衍生物与由式(14)表示的苯酚衍生物反应；一种生产式(18)所代表的环状偶氮染料的工艺，包括在碱性气氛中用氧化剂使式(16)或(17)所代表的苯胺衍生物发生氧化反应；以及一种生产式(3)所代表的环状偶氮染料的工艺，包括在碱性气氛中，在有氧化剂存在的情况下，使式(19)所代表的羰基化合物衍生物与式(20)所代表的苯胺化合物衍生物或其盐发生反应。
• Synthesis of 4-oxo-1,3-benz- and naphthoxazinium salts from o-hydroxyarylamides
  作者：O. Yu. Ryabukhina、Yu. I. Ryabukhin、B. S. Luk'yanov、G. N. Dorofeenko

  DOI：10.1007/bf00514728

  日期：1979.12
• Movchan, A. I.; Yablokova, E. V.; Kalukov, A. A., Russian Journal of Organic Chemistry, 1993, vol. 29, # 7.2, p. 1179 - 1185
  作者：Movchan, A. I.、Yablokova, E. V.、Kalukov, A. A.、Chmutova, G. A.

  DOI：——

  日期：——
• Wagner; Kamecki; Leistner, Pharmazie, 1976, vol. 31, # 10, p. 704 - 707
  作者：Wagner、Kamecki、Leistner

  DOI：——

  日期：——