1-羟基萘-2-羧酸钠盐 | 18396-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-羟基萘-2-羧酸钠盐
• 英文名称: sodium salt of 1-hydroxynaphthalene-2-carboxylic acid
• 英文别名: 1-hydroxy-2-naphthoic acid sodium salt；sodium xinafoate；1-hydroxynaphthalene-2-carboxylic acid sodium salt；sodium 1-hydroxy-2-naphthoate；1-Hydroxy-[2]naphthoesaeure; Natrium-Verbindung；1-hydroxy-[2]naphthoic acid ; sodium-compound；Sodium;2-carboxynaphthalen-1-olate；sodium;2-carboxynaphthalen-1-olate
• CAS: 18396-51-5
• 化学式: C₁₁H₇O₃*Na
• 分子量: 210.165
• InChiKey: SWQYFLFAUHYVLM-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.09
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-羟基萘-2-羧酸钠盐 在 草酰氯 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 1-hydroxy-2-naphthoyl chloride
  参考文献：
  名称：

  Lamothe, Marie; Fuchs, Journal of the American Chemical Society, 1993, vol. 115, # 11, p. 4483 - 4496

  摘要：

  DOI：

文献信息

• An orally administrable drug form comprising a beta-lactam antibiotic and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0036534A1

  公开（公告）日：1981-09-30

  A drug form is provided for increasing the oral absorption of β-lactam antibiotics such as the penicillins, cephalosporins and related chemical species by the oral administration of said β-lactam antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxy aryl or hydroxy aralkyl acid or salt, amide or ester thereof. The hydroxyaryl or hydroxyaralkyl acid or salt, amide or ester thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of the β-lactam antibiotic.

  本发明提供了一种药物形式，通过将β-内酰胺类抗生素口服于适当的药学上可接受的赋形剂中，并在赋形剂中加入羟基芳基或羟基芳烷基酸或其盐、酰胺或酯，从而增加β-内酰胺类抗生素如青霉素类、头孢菌素类及相关化学物质的口服吸收。羟基芳基或羟基烷基酸或其盐、酰胺或酯在药物形式中的含量足以有效提高 β-内酰胺类抗生素的口服吸收率。
• An orally administered drug form comprising a glycosidic antibiotic and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0035770A2

  公开（公告）日：1981-09-16

  A drug form is provided for increasing the oral absorption of glycosidic and related antibiotics such as marcrolide, aminoglycoside, lincomycin and anthracycline antibiotics and related chemical species by the oral administration of said glycosidic and related antibiotics in a suitable pharmaceutically accepted excipient to which has been added a hydroxyaryl or hydroxyaralkyl acid or salt amide or ester thereof. The hydroxyaryl, a hydroxyaralkyl or salt amide or ester thereof is present in the drug form in quantities sufficient to be effective in enhancing the rate of oral absorption of glycosidic and related antibiotic.

  本发明提供了一种药物剂型，用于提高糖苷类和相关抗生素（如马克隆、氨基糖苷、林可霉素和蒽环类抗生素及相关化学物质）的口服吸收率，方法是将所述糖苷类和相关抗生素置于适当的药学上可接受的赋形剂中，并在赋形剂中添加羟基芳基或羟基烷基酸或盐酰胺或酯。 药物剂型中羟基芳基、羟基烷基或盐酰胺或酯的含量足以有效提高糖苷类和相关抗生素的口服吸收率。
• An orally administered drug form comprising a polar bioactive agent and an adjuvant
  申请人：INTERx RESEARCH CORPORATION

  公开号：EP0036145A1

  公开（公告）日：1981-09-23

  A drug form is provided for increasing the oral absorption of polar bioactive agents such as xanthines, polyhydroxylic substances, zwitterions, polypeptides and organic anions and related chemical species by the oral administration of said polar bioactive agents in a suitable pharmaceutically accepted excipientto which has been added a hydroxyaromatic, hydroxyaryl or hydroxy aralkyl acid or salt amide or ester thereof. The hydroxy aryl or hydroxy aralkyl acid or salt amide or ester thereof is present in the drug form in quantities suffi- cientto be effective in enhancing the rate of oral absorption of the polar bioactive agents.

  本发明提供了一种药物剂型，用于增加极性生物活性剂（如黄嘌呤、多羟基物质、 齐聚物、多肽和有机阴离子及相关化学物质）的口服吸收，方法是将所述极性生物活性 剂口服在一种适当的药学上可接受的赋形剂中，在赋形剂中添加羟基芳基、羟基芳基或 羟基烷基酸或其酰胺盐或酯。羟基芳基或羟基烷基酸或其酰胺盐或酯在药物形式中的存在量足以有效提高极性生物活性剂的口服吸收率。
• Synthesis and Cytotoxicity of 5-Amino-1-(chloromethyl)-3-[(5,6,7-trimethoxyindol-2-yl)carbonyl]-1,2- dihydro-3<i>H</i>-benz[<i>e</i>]indole (Amino-<i>s</i><i>eco</i>-CBI-TMI) and Related 5-Alkylamino Analogues:  New DNA Minor Groove Alkylating Agents
  作者：Graham J. Atwell、Moana Tercel、Maruta Boyd、William R. Wilson、William A. Denny

  DOI：10.1021/jo981395w

  日期：1998.12.1

  The first synthesis of seco-CBI-TMI alkylating agents with 5-nitrogen substituents is reported. The parent 5-amino compound was prepared in a 15-step synthesis from 1-hydroxynaphthalene-2-carboxylic acid. Reductive alkylation of the 5-amino compound gave the corresponding 5-methylamino and 5-dimethylamino analogues, while resolution of an intermediate by chiral HPLC allowed preparation of the R and S enantiomers of the 5-amino analogue. Absolute configuration was assigned by X-ray crystallography. The S enantiomer was about 65-fold more cytotoxic than the R enantiomer in cell line assays. The 5-amino and 5-methylamino compounds had in vitro cytotoxicities comparable to that of the known 5-hydroxy analogue (0.2-0.5 nM), while the 5-dimethylamino derivative was about 10-fold less potent. The high potencies of the 5-amino and 5-methylamino analogues make them of interest for the formation of relatively stable amine-based prodrugs.
• NEEB, RUDOLF;TRONICH, WOLFGANG;VOLK, HEINRICH
  作者：NEEB, RUDOLF、TRONICH, WOLFGANG、VOLK, HEINRICH

  DOI：——

  日期：——