10-炔丙基氨基喋呤 | 82318-25-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 中文名称: 10-炔丙基氨基喋呤
• 英文名称: 10-Propargylaminopterin
• 英文别名: 2-[[4-[(2,4-diaminopteridin-6-yl)methyl-prop-2-ynylamino]benzoyl]amino]pentanedioic acid
• CAS: 82318-25-0
• 化学式: C₂₂H₂₂N₈O₅
• 分子量: 478.5
• InChiKey: GMNLACQTNWJVHI-UHFFFAOYSA-N

物化性质

• 密度：
  1.531±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  211
• 氢给体数：
  5
• 氢受体数：
  12

文献信息

• Polymer Conjugate Of Folic Acid Or Folic Acid Derivative
  申请人：Nakanishi Takeshi

  公开号：US20110294980A1

  公开（公告）日：2011-12-01

  Disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein an amide bond is not used. The compound has chemical stability and adequate drug release rate in the living organism. Specifically disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein a substituent represented by formula (I) is bonded to a carboxy group of a block copolymer which is composed of a polyethylene glycol and a polymer having a carboxy group in a side chain, or a pharmacologically acceptable salt thereof. [In the formula, A represents a monocyclic or fused aromatic group; G represents an optionally substituted (C1-C6) alkylene group; Y represents a hydrogen atom or a substituent; and E represents a residue of folic acid or a folic acid derivative.]

  揭示了一种叶酸或叶酸衍生物的聚合物共轭物，其中未使用酰胺键。该化合物在活体内具有化学稳定性和适当的药物释放速率。具体揭示了一种叶酸或叶酸衍生物的聚合物共轭物，其中配体由式(I)所表示的取代基与由聚乙二醇和具有侧链上羧基的聚合物组成的嵌段共聚物的羧基结合，或其药理学上可接受的盐。[在该式中，A代表单环或融合芳香基团；G代表可选取代的(C1-C6)烷基基团；Y代表氢原子或取代基；E代表叶酸或叶酸衍生物的残基。]
• POLYMER CONJUGATE OF FOLIC ACID OR FOLIC ACID DERIVATIVE
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP2284209A1

  公开（公告）日：2011-02-16

  Disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein an amide bond is not used. The compound has chemical stability and adequate drug release rate in the living organism. Specifically disclosed is a polymer conjugate of folic acid or a folic acid derivative, wherein a substituent represented by formula (I) is bonded to a carboxy group of a block copolymer which is composed of a polyethylene glycol and a polymer having a carboxy group in a side chain, or a pharmacologically acceptable salt thereof. [In the formula, A represents a monocyclic or fused aromatic group; G represents an optionally substituted (C1-C6) alkylene group; Y represents a hydrogen atom or a substituent; and E represents a residue of folic acid or a folic acid derivative.]

  本发明公开了一种叶酸或叶酸衍生物的聚合物共轭物，其中未使用酰胺键。该化合物在生物体内具有化学稳定性和足够的药物释放率。具体公开了一种叶酸或叶酸衍生物的聚合物共轭物，其中由式（I）代表的取代基键合到嵌段共聚物的羧基上，嵌段共聚物由聚乙二醇和侧链中含有羧基的聚合物组成，或其药理学上可接受的盐。 [式中，A 代表单环或融合芳香基团；G 代表任选取代的（C1-C6）亚烷基；Y 代表氢原子或取代基；E 代表叶酸残基或叶酸衍生物。］
• US9149540B2
  申请人：——

  公开号：US9149540B2

  公开（公告）日：2015-10-06