11-去乙酰氧基渥曼青霉素 | 31652-69-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 11-去乙酰氧基渥曼青霉素
• 英文名称: 11-desacetoxy-wortmannin
• 英文别名: 11-Desacetoxywortmannin；(1R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-triene-6,11,16-trione
• CAS: 31652-69-4
• 化学式: C₂₁H₂₂O₆
• 分子量: 370.402
• InChiKey: GXVZXRZMWGYXMQ-DJOOALQISA-N

物化性质

• 沸点：
  578.1±50.0 °C(Predicted)
• 密度：
  1.36±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  82.8
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• METHODS AND COMPOSITIONS FOR TREATING NEOINTIMAL HYPERPLASIA
  申请人：Marks Andrew R.

  公开号：US20090274739A1

  公开（公告）日：2009-11-05

  The present invention relates to compositions containing an mTOR inhibitor, such as rapamycin or a rapamycin derivative, in combination with a PI3 kinase inhibitor and/or a leptin inhibitor, intraluminal devices configured to release such compositions, and methods for the treatment and/or prevention of intimal hyperplasia, vascular stenosis and/or restenosis comprising delivery of such compositions or intraluminal devices to subjects in need thereof. The compositions, intraluminal devices, and methods of the invention are particularly well-suited for the treatment or prevention of vascular stenosis and restenosis in obese and diabetic subjects.