15-羟基黄体酮 | 600-72-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 15-羟基黄体酮
• 英文名称: (8R,9S,10R,13S,14S,17S)-17-acetyl-15-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS: 600-72-6
• 化学式: C₂₁H₃₀O₃
• 分子量: 330.5
• InChiKey: LEWIUXKKQXGQRR-PWTOQQMXSA-N

物化性质

• 熔点：
  204-205 °C(Solv: acetone (67-64-1))
• 沸点：
  487.4±45.0 °C(Predicted)
• 密度：
  1.15±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Bile compound and method of controlling behavior of lampreys therewith
  申请人：Board of Trustees of MICHIGAN STATE UNIVERSITY

  公开号：US20030108583A1

  公开（公告）日：2003-06-12

  Novel compounds isolated from the bile of male sea lampreys are described, in particular, 7&agr;,12&agr;,24-trihydroxy-5&agr;-cholan-3-one-24-sulfate and 7&agr;,12&agr;-dihydroxy-5&agr;-cholan-3-one-24-oic acid and an ELISA for detecting the compounds. The bile compounds act as pheromones which attract female sea lampreys in water to the point in the water where the compounds had been introduced. The bile compounds are useful in lamprey population management programs where it is desirable to control the locomotion and distribution of lampreys and in food operations where it enhances the efficiency of catching lampreys for food.

  本文描述了从雄性海灯鱼胆汁中分离出的新型化合物，特别是 7&agr;,12&agr;,24-三羟基-5&agr;-胆烷-3-酮-24-硫酸盐和 7&agr;,12&agr;-二羟基-5&agr;-胆烷-3-酮-24-酸，以及检测这些化合物的 ELISA 方法。胆汁化合物可作为信息素，将水中的雌性海灯鱼吸引到引入化合物的水域。胆汁化合物可用于灯鱼种群管理计划，控制灯鱼的运动和分布；也可用于食品加工，提高捕捉灯鱼作为食物的效率。
• COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS
  申请人：The Hospital For Sick Children

  公开号：EP2598150A2

  公开（公告）日：2013-06-05
• US6881729B2
  申请人：——

  公开号：US6881729B2

  公开（公告）日：2005-04-19
• US8748177B2
  申请人：——

  公开号：US8748177B2

  公开（公告）日：2014-06-10
• [EN] COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS<br/>[FR] COMPOSITIONS POUR LA PROLIFÉRATION DE CELLULES ET PROCÉDÉS ASSOCIÉS
  申请人：HOSPITAL FOR SICK CHILDREN

  公开号：WO2010039679A1

  公开（公告）日：2010-04-08

  We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.