1H-[1,2,3]三唑并[4,5-c]吡啶-1-醇 | 185839-73-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并吡啶类
• 中文名称: 1H-[1,2,3]三唑并[4,5-c]吡啶-1-醇
• 英文名称: 1-hydroxy-5-azabenzotriazole
• 英文别名: 5-aza-1-hydroxybenzotriazole；1-hydroxytriazolo[4,5-c]pyridine
• CAS: 185839-73-0
• 化学式: C₅H₄N₄O
• 分子量: 136.113
• InChiKey: YFYIKMFTXUYSEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-苄氧羰酰基-2-甲基丙氨酸 、 1H-[1,2,3]三唑并[4,5-c]吡啶-1-醇 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Comparison of the Effects of 5- and 6-HOAt on Model Peptide Coupling Reactions Relative to the Cases for the 4- and 7-Isomers^,

  摘要：

  [GRAPHICS]Synthesis of 5- and 6-HOAt has completed the full set of the four HOAt isomers derived from HOBt by insertion of a single nitrogen atom in the benzenoid nucleus. Comparison of the reactivity of all four isomers in model peptide coupling reactions has confirmed the unique character of the 7-isomer in promoting selectivity and maintaining configuration at the reactive carboxylic acid residue.

  DOI：

  10.1021/ol006013z
• 作为产物：
  描述：

  1-Methoxy-1H-[1,2,3]triazolo[4,5-c]pyridine 5-oxide 在 sodium thiophenolate 、 三氯化磷 作用下， 以 氘代二甲亚砜 、 氘代氯仿 、 氯仿 为溶剂， 生成 1H-[1,2,3]三唑并[4,5-c]吡啶-1-醇
  参考文献：
  名称：

  Comparison of the Effects of 5- and 6-HOAt on Model Peptide Coupling Reactions Relative to the Cases for the 4- and 7-Isomers^,

  摘要：

  [GRAPHICS]Synthesis of 5- and 6-HOAt has completed the full set of the four HOAt isomers derived from HOBt by insertion of a single nitrogen atom in the benzenoid nucleus. Comparison of the reactivity of all four isomers in model peptide coupling reactions has confirmed the unique character of the 7-isomer in promoting selectivity and maintaining configuration at the reactive carboxylic acid residue.

  DOI：

  10.1021/ol006013z

文献信息

• Reagents for peptide couplings
  申请人：Research Corporation Technologies, Inc.

  公开号：US05644029A1

  公开（公告）日：1997-07-01

  This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: ##STR1## and N-oxides thereof and salts thereof.

  本发明涉及一种从氨基或醇和羧酸酰化衍生物的反应中形成酰胺或酯的过程，在有效量的化合物存在下，该化合物具有以下公式：##STR1##和其N-氧化物和盐。
• Azahydroxybenzotriazoles and derivatives thereof for peptide coupling
  申请人：Research Corporation Technologies, Inc.

  公开号：US05580981A1

  公开（公告）日：1996-12-03

  This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: ##STR1## and N-oxides thereof and salts thereof.

  本发明涉及一种制备酰化衍生物与胺或醇分别反应形成酰胺或酯的方法，其在化合物式为：##STR1##及其N-氧化物和盐的有效量存在下进行。
• USRE038073E1
  申请人：——

  公开号：——

  公开（公告）日：——
• USRE037686E1
  申请人：——

  公开号：——

  公开（公告）日：——
• Comparison of the Effects of 5- and 6-HOAt on Model Peptide Coupling Reactions Relative to the Cases for the 4- and 7-Isomers^,
  作者：Louis A. Carpino、Hideko Imazumi、Bruce M. Foxman、Michael J. Vela、Peter Henklein、Ayman El-Faham、Jana Klose、Michael Bienert

  DOI：10.1021/ol006013z

  日期：2000.7.1

  [GRAPHICS]Synthesis of 5- and 6-HOAt has completed the full set of the four HOAt isomers derived from HOBt by insertion of a single nitrogen atom in the benzenoid nucleus. Comparison of the reactivity of all four isomers in model peptide coupling reactions has confirmed the unique character of the 7-isomer in promoting selectivity and maintaining configuration at the reactive carboxylic acid residue.