2',7'-二溴-3',6'-二羟基螺[2-苯并呋喃-3,9'-氧杂蒽]-1-酮 | 25709-81-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 中文名称: 2',7'-二溴-3',6'-二羟基螺[2-苯并呋喃-3,9'-氧杂蒽]-1-酮
• 英文名称: 2',7'-dibromo-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one
• 英文别名: 2',7'-Dibrom-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-on；2',7'-dibromo-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-[9H]xanthene)-3-one；2',7'-Dibrom-fluorescein；2,7-Dibromfluorescein；2',7'-Dibromofluorescein；2',7'-dibromo-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 25709-81-3
• 化学式: C₂₀H₁₀Br₂O₅
• 分子量: 490.104
• InChiKey: YNBZQSXWRWAXMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

制备方法与用途

用途：汞溴红的中间体。

生产方法：通过让邻苯二甲酸酐与间苯二酚在发烟硫酸的作用下进行缩合反应生成荧光素，再用溴素对其进行溴化处理，从而得到目标产品。

反应信息

• 作为反应物：
  描述：

  2',7'-二溴-3',6'-二羟基螺[2-苯并呋喃-3,9'-氧杂蒽]-1-酮 在 sodium hydroxide 、 乙醇 、 氢溴酸 作用下， 生成 2',4',7'-tribromo-3',6'-dihydroxy-spiro[phthalan-1,9'-xanthen]-3-one
  参考文献：
  名称：

  Graichen; Molitor, Journal of the Association of Official Agricultural Chemists, 1959, vol. 42, p. 149,159

  摘要：

  DOI：
• 作为产物：
  描述：

  溶剂红 43 在 1,4-二氧六环 、 盐酸 、 溶剂黄146 作用下， 生成 2',7'-二溴-3',6'-二羟基螺[2-苯并呋喃-3,9'-氧杂蒽]-1-酮
  参考文献：
  名称：

  The Structure of Fluorescein, Sulfonefluorescein and Some of their Halogenated Derivatives

  摘要：

  DOI：

  10.1021/ja01265a098

文献信息

• Drug delivery system for hydrophobic drugs
  申请人：QLT, Inc.

  公开号：EP1900357A2

  公开（公告）日：2008-03-19

  Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.

  本文介绍了由含有疏水性药物的微团聚体组成的组合物及其生产方法。这种微团聚体可包括胶束结构或其与脂质体的组合，并构成疏水性药物的有效递送载体。微团聚体的生产方法包括使用优选的脂质化合物和有利于生产小团聚体的加工条件，以提高过滤灭菌效果。
• Biophotonic materials and uses thereof
  申请人：KLOX TECHNOLOGIES INC.

  公开号：US10130706B2

  公开（公告）日：2018-11-20

  The present disclosure provides topical biophotonic materials and methods useful in phototherapy. In particular, the topical biophotonic materials of the present disclosure include a cohesive matrix, and at least chromophore which can absorb and emit light from within the topical biphotonic material, wherein the topical biophotonic material is elastic. The topical biophotonic materials and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various other skin disorders.

  本公开提供了用于光疗的局部生物光子材料和方法。特别是，本公开的局部生物光子材料包括粘性基质，以及至少能从局部双光子材料内部吸收和发射光的发色团，其中局部生物光子材料具有弹性。本公开的外用生物光子材料和方法可用于促进伤口愈合和嫩肤，以及治疗痤疮和其他各种皮肤疾病。
• Tissue filler compositions and methods of use
  申请人：KLOX Technologies Inc.

  公开号：US10207029B2

  公开（公告）日：2019-02-19

  The present disclosure relates to methods for stimulating collagen synthesis, cosmetic enhancement of soft tissue and/or inhibiting or treating scarring comprising administering a composition to an area to be treated within a soft tissue, wherein the composition comprises a tissue filler medium and a fluorophore; and illuminating the area with light having a wavelength which can be absorbed by the fluorophore.

  本公开涉及刺激胶原蛋白合成、软组织美容增强和/或抑制或治疗瘢痕的方法，包括向软组织内待治疗区域施用组合物，其中组合物包括组织填充介质和荧光团；以及用具有可被荧光团吸收的波长的光照射该区域。
• Biophotonic compositions and methods for providing biophotonic treatment
  申请人：KLOX Technologies Inc.

  公开号：US10376455B2

  公开（公告）日：2019-08-13

  The present disclosure provides biophotonic topical compositions and methods useful in phototherapy. In particular, the biophotonic topical compositions of the present disclosure are substantially resistant to leaching such that very low amounts of chromophore(s) present in the biophotonic composition leach out of the composition. The biophotonic compositions and the methods of the present disclosure are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.

  本公开提供了用于光疗的生物光子局部组合物和方法。特别是，本公开的生物光子外用组合物具有很强的抗浸出性，因此生物光子组合物中存在的发色团从组合物中浸出的量极少。本公开的生物光子组合物和方法可用于促进伤口愈合和皮肤再生，以及治疗痤疮和各种皮肤疾病。
• Phototherapy devices and methods
  申请人：KLOX Technologies Inc.

  公开号：US10687926B2

  公开（公告）日：2020-06-23

  The present disclosure relates to a phototherapy device that can deliver light to tissues to activate photoactive agents that have been applied to the tissues or that are included within a fiber optic tip member of the device which may be coupled to a light source using a sleeve. The present disclosure also relates to methods of phototherapy using the phototherapy device such as anti-bactericidal treatment, anti-fungal treatment, anti-parasitic treatment, anti-viral treatment.

  本公开涉及一种光疗装置，该装置可将光输送到组织，以激活涂抹在组织上的光活性剂，或包括在该装置的光纤尖端部件内的光活性剂，该装置可使用套管与光源耦合。本公开还涉及使用光疗装置进行光疗的方法，如抗菌治疗、抗真菌治疗、抗寄生虫治疗、抗病毒治疗。