2,3-二异丙基喹喔啉 | 77611-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2,3-二异丙基喹喔啉
• 英文名称: 2,3-diisopropylquinoxaline
• 英文别名: 2,3-Diisopropyl-chinoxalin；2,3-di(propan-2-yl)quinoxaline
• CAS: 77611-56-4
• 化学式: C₁₄H₁₈N₂
• 分子量: 214.31
• InChiKey: VQTKKEJOKCNBRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2,5-二甲基-3,4-己烷二酮 、 邻苯二胺 在 水 作用下， 生成 2,3-二异丙基喹喔啉
  参考文献：
  名称：

  Landquist; Stacey, Journal of the Chemical Society, 1953, p. 2822,2827

  摘要：

  DOI：

文献信息

• ELECTROCHROMIC SINGLE AND TWO-CORE VIOLOGENS AND OPTICAL ARTICLES CONTAINING THEM
  申请人：ESSIL OR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE

  公开号：US20160231635A1

  公开（公告）日：2016-08-11

  The present invention relates to a group of novel electrochromic materials. More specifically, it relates to electrochromic materials based on either single or two-core viologen systems and the use of these viologen systems as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens.

  本发明涉及一组新颖的电致变色材料。更具体地说，它涉及基于单一或双核心紫罗兰体系的电致变色材料，以及将这些紫罗兰体系用作可变透射率介质，用于制造光学产品，例如眼镜片。
• [EN] MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES<br/>[FR] INHIBITEURS MACROCYCLIQUES DE PEPTIDYLARGININE DÉIMINASES
  申请人：GILEAD SCIENCES INC

  公开号：WO2021222353A1

  公开（公告）日：2021-11-04

  The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

  本公开涉及用于治疗与肽精氨酸脱亚氨酶（PADs）相关的疾病的新化合物，例如肽精氨酸脱亚氨酶类型4（PAD4）。本公开还涉及用于制备这些化合物的过程和中间体，使用这些化合物的方法以及包含所述化合物的药物组合物。
• ELECTROCHROMIC TWO-CORE VIOLOGEN DERIVATIVES AND OPTICAL ARTICLES CONTAINING THEM
  申请人：ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE)

  公开号：US20160221949A1

  公开（公告）日：2016-08-04

  The present invention relates to a group of novel electrochromic materials. More specifically, it relates to electrochromic materials having two-core viologens and the use of these two-core viologens as a variable transmittance medium for the manufacture of an optical article, such as an ophthalmic lens.

  本发明涉及一组新型电致变色材料。更具体地，涉及具有双核紫精的电致变色材料，以及将这些双核紫精用作可变透射率介质制造光学制品，如眼镜镜片。
• LIGAND, METAL COMPLEX CONTAINING LIGAND, AND REACTION USING METAL COMPLEX CONTAINING LIGAND
  申请人：NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY

  公开号：US20160107151A1

  公开（公告）日：2016-04-21

  A hydrogen transfer reaction may be more efficiently promoted by using a metal complex represented by Formula (2): (wherein, R 1 to R 8 are the same or different, and each represents a hydrogen atom, a substituted or unsubstituted alkyl group or the like; or wherein; R 1 and R 2 , R 2 and R 3 , R 3 and R 4 , R 4 and R 5 , and R 5 and R 6 are respectively bonded to each other to form a bivalent hydrocarbon group; R 9 are the same or different, and each represents an alkyl group or cycloalkyl group; M is ruthenium (Ru) or the like; X is a ligand; and n is 0, 1 or 2). More specifically, the metal complex enables a hydrogenation reaction of various substrates having a stable carbonyl group or the like to be advanced with a high yield under mild conditions.

  一种氢转移反应可以更有效地促进，通过使用由公式（2）表示的金属配合物：（其中，R1至R8相同或不同，每个代表氢原子，取代或未取代的烷基或类似物; 或其中; R1和R2，R2和R3，R3和R4，R4和R5以及R5和R6分别与彼此结合形成双价碳氢基; R9相同或不同，每个代表烷基或环烷基; M是钌（Ru）或类似物; X是配体; n为0，1或2）。更具体地说，该金属配合物使得具有稳定的羰基基团或类似物的各种底物的氢化反应可以在温和的条件下高产率地进行。
• Aryl nitrile compounds and compositions and their uses in treating inflammatory and related disorders
  申请人：Bergeron Philippe

  公开号：US20070015773A1

  公开（公告）日：2007-01-18

  Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides aryl nitrile compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis, type I diabetes, asthma, psoriasis and inflammatory bowel disease.

  本文提供了在治疗炎症和免疫相关疾病中有用的化合物、组合物和方法。具体来说，本发明提供了可以调节趋化因子受体的表达和/或功能的芳基腈化合物。这些方法适用于治疗炎症和免疫调节性疾病，例如多发性硬化症、类风湿性关节炎、1型糖尿病、哮喘、牛皮癣和炎症性肠病。