2,3-二氢-1,4-苯并二噁英-6-胺盐酸盐 | 801316-07-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 中文名称: 2,3-二氢-1,4-苯并二噁英-6-胺盐酸盐
• 中文别名: 6-氨基-1,4-苯并二氧杂环盐酸盐
• 英文名称: 6-Amino-1,4-benzodioxane hydrochloride
• 英文别名: 2,3-dihydro-benzo[1,4]dioxin-6-ylamine; hydrochloride；2,3-Dihydrobenzo[b][1,4]dioxin-6-amine hydrochloride；2,3-dihydro-1,4-benzodioxin-6-amine;hydrochloride
• CAS: 801316-07-4
• 化学式: C₈H₉NO₂*ClH
• 分子量: 187.626
• InChiKey: JOJCJWOSSAPNCW-UHFFFAOYSA-N

物化性质

• 熔点：
  220℃ (Decomposition)

计算性质

• 辛醇/水分配系数(LogP)：
  1.46
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  2,3-二氢-1,4-苯并二噁英-6-胺盐酸盐 在 水 、 硝酸 、 sodium acetate 、 溶剂黄146 作用下， 生成 6-acetamido-7-nitro-2,3-dihydro-1,4-benzodioxine
  参考文献：
  名称：

  Heertjes; Revallier, Recueil des Travaux Chimiques des Pays-Bas, 1950, vol. 69, p. 262,267

  摘要：

  DOI：

文献信息

• Vanilloid receptor ligands and their use in treatments
  申请人：Hulme Christopher

  公开号：US20050165046A1

  公开（公告）日：2005-07-28

  bis-Bicyclic amides and derivatives thereof and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

  双环酰胺及其衍生物以及含有它们的组合物，用于治疗急性、炎症性和神经痛、牙痛、普通头痛、偏头痛、集群头痛、混合血管性和非血管性综合征、紧张性头痛、一般炎症、关节炎、风湿病、骨关节炎、炎症性肠道疾病、炎症性眼部疾病、炎症性或不稳定的膀胱疾病、牛皮癣、伴有炎症成分的皮肤疾病、慢性炎症症状、炎症性疼痛及相关的痛觉过敏和触痛、神经痛及相关的痛觉过敏和触痛、糖尿病性神经病痛、烧伤性神经痛、交感神经维持性疼痛、感觉缺失综合征、哮喘、上皮组织损伤或功能障碍、单纯疱疹、呼吸、泌尿、消化或血管区域内脏运动障碍、伤口、烧伤、过敏性皮肤反应、瘙痒、白癜风、一般胃肠道疾病、胃溃疡、十二指肠溃疡、腹泻、由坏死性因子引起的胃溃疡、毛发生长、血管运动或过敏性鼻炎、支气管疾病或膀胱疾病。
• Quinoline derivatives as phosphodiesterase inhibitors
  申请人：Barker David Michael

  公开号：US20060178416A1

  公开（公告）日：2006-08-10

  There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

  根据本发明提供了公式(I)的新化合物或其药学上可接受的盐，其中R1、R2、R19、R20和R34如规范所述，以及制备它们的过程、包含它们的制剂和它们在治疗炎症性疾病方面的用途。
• Quinoline Derivatives As Phosphodiesterase Inhibitors
  申请人：Baldwin Ian Robert

  公开号：US20090312325A1

  公开（公告）日：2009-12-17

  There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20, and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

  根据本发明提供了一种新的化合物式(I)或其药学上可接受的盐，其中R1、R2、R19、R20和R34如规范所述，以及制备它们的过程、含有它们的制剂以及它们在治疗炎症性疾病方面的用途。
• Quinoline derivatives as phosphodiesterase inhibitors
  申请人：GLAXO GROUP LIMITED

  公开号：EP1944305A1

  公开（公告）日：2008-07-16

  There are provided according to the invention novel compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R19, R20 and R34 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.

  根据本发明提供了式 (I) 的新型化合物或其药学上可接受的盐类（其中 R1、R2、R19、R20 和 R34 如说明书所述）、制备它们的工艺、含有它们的制剂以及它们在治疗炎症性疾病中的用途。
• Synthesis and pharmacological activity of 5,6-and 4,5-ethylenedioxytryptamines
  作者：D. A. Partsvaniya、R. N. Akhvlediani、E. N. Gordeev、M. M. Vigdorchik、L. N. Kuleshova、T. K. Trubitsyna、M. D. Mashkovskii、N. N. Suvorov

  DOI：10.1007/bf00763713

  日期：1986.12