2,3-二甲基-2,3-二氢-1,4-酞嗪二酮 | 22527-64-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2,3-二甲基-2,3-二氢-1,4-酞嗪二酮
• 英文名称: 2,3-Dimethyl-1,2,3,4-tetrahydro-phthalazin-1,4-dion
• 英文别名: 2,3-Dimethyl-2,3-dihydrophthalazine-1,4-dione；2,3-dimethylphthalazine-1,4-dione
• CAS: 22527-64-6
• 化学式: C₁₀H₁₀N₂O₂
• 分子量: 190.202
• InChiKey: MYVHRYPUAHGCPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2,3-二甲基-2,3-二氢-1,4-酞嗪二酮 在 乙醇 、 镍 作用下， 生成 N-甲基邻苯二甲酰亚胺
  参考文献：
  名称：

  Hydrogenolysis of the Nitrogen—Nitrogen Bond of Acylhydrazines with Raney Nickel

  摘要：

  DOI：

  10.1021/jo01353a013
• 作为产物：
  描述：

  邻苯二甲酸亚胺 、 1,2-二甲基肼 在 N,N-二异丙基乙胺 作用下， 以 乙醇 为溶剂， 生成 2,3-二甲基-2,3-二氢-1,4-酞嗪二酮
  参考文献：
  名称：

  组合裂解和脱保护方案的实施。1.邻苯二甲酰肼库的合成

  摘要：

  邻苯二甲酰肼库是由取代的肼和邻苯二甲酰亚胺以几种不同的库格式在溶液中合成的，包括单一化合物，索引子库和完整的库。当在固相合成过程中进行时，这种组合的裂解和脱保护方案为生成取代的邻苯二甲酰肼的多样化文库提供了可能性。

  DOI：

  10.1016/0040-4039(96)00544-8

文献信息

• Synthesis of tetrahydrophthalazine and phthalamide (phthalimide) derivatives via palladium-catalysed carbonylation of iodoarenes
  作者：Diána Marosvölgyi-Haskó、Andrea Petz、Attila Takács、László Kollár

  DOI：10.1016/j.tet.2011.09.095

  日期：2011.11

  4-Tetrahydrophthalazin-1-one and 1,2,3,4-tetrahydrophthalazin-1,4-dione derivatives were synthesised in high (up to 85%) and low yields using 2-iodobenzyl bromide and 1,2-diiodobenzene as bifunctional substrates, respectively. Iodoarenes, carbon monoxide and various hydrazine derivatives as N-nucleophiles were used in a three-component palladium-catalysed cascade hydrazinocarbonylation. A similar palladium-catalysed

  1,2,3,4-四氢酞嗪-1-酮和1,2,3,4-四氢酞嗪-1,4-二酮衍生物是使用2-碘代苄基溴和1的高产率（高达85％）和低产率合成的，2-二碘苯分别作为双功能底物。碘芳烃，一氧化碳和各种作为N-亲核试剂的肼衍生物被用于三组分钯催化的级联肼羰基化反应中。类似的钯催化反应，即1,2-二碘苯的氨基羰基化反应，主要导致形成两种主要产物，具体取决于胺N-亲核试剂：使用伯胺可产生N取代的邻苯二甲酰亚胺进行双羰基化，同时仲胺与碘芳烃官能团之一反应，得到相应的2-碘代苯甲酰胺。由于在一个或两个碘代芳烃官能团处插入一氧化碳两次，可以通过改变反应条件来分离出酮羧酰胺-羧酰胺或双酮羧酰胺衍生物。还讨论了闭环反应的一些机理细节和导致副产物的条件。
• Beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions
  申请人：Trieselmann Thomas

  公开号：US20080234278A1

  公开（公告）日：2008-09-25

  The present invention relates to new beta-agonists of general formula (I) wherein the groups R 1 to R 7 have the meanings given in the claims and specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, processes for preparing these compounds and their use as pharmaceutical compositions.

  本发明涉及通式（I）的新型β-激动剂，其中R1至R7的基团具有权利要求书和说明书中所给出的含义，它们的互变异构体、对映异构体、顺反异构体、混合物、前药及其盐，特别是与无机或有机酸或碱的生理上可接受的盐，制备这些化合物的过程以及它们作为药物组成物的用途。
• Persistent, Consistent, Widespread, and Robust? Another Look at Recent Trends in Old-Age Disability
  作者：R. F. Schoeni、V. A. Freedman、R. B. Wallace

  DOI：10.1093/geronb/56.4.s206

  日期：2001.7.1

  Objective. The purpose of this study was to provide new evidence on disability trends among elderly persons from 1982 to 1996.Methods. The sample includes 125,949 participants aged 70 and older in the 1982-1996 National Health Interview Surveys. Logistic analysis was used to estimate the trend in disability prevalence after controlling for various sociodemographic factors.Results. We found that: (a) the prevalence of disability has declined, but the gains did not persist throughout the entire period or accelerate over time: (b) only routine care disability has declined. whereas more severe personal care disability shows no improvements; (c) estimates are robust to the exclusion of the nursing home population but may be sensitive to growth in the assisted living population: (d) estimates of decline in disability prevalence are fairly consistent across five national surveys: (e) gains have been concentrated among the most educated elderly persons: and (F) gains in education appear to be an important confounder of the improvements.Discussion. Evidence from several surveys using various measures indicate that disability has declined among elderly persons. Determining the causes of the improvements should be a high priority in future research efforts.
• Blanksma; Bakels, Recueil des Travaux Chimiques des Pays-Bas, 1939, vol. 58, p. 497,498
  作者：Blanksma、Bakels

  DOI：——

  日期：——
• Przheval'skii, N. M.; Drozd, V. N., Journal of Organic Chemistry USSR (English Translation), 1990, vol. 26, # 1.2, p. 184
  作者：Przheval'skii, N. M.、Drozd, V. N.

  DOI：——

  日期：——