2,3-双(3,4-二羟基苯基)丁二酸 | 653572-63-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 2,3-双(3,4-二羟基苯基)丁二酸
• 英文名称: 2,3-bis-(3,4-dihydroxy-phenyl)-succinic acid
• 英文别名: 2,3-Bis-(3,4-dihydroxy-phenyl)-bernsteinsaeure；2,3-Bis(3,4-dihydroxyphenyl)butanedioic acid
• CAS: 653572-63-5
• 化学式: C₁₆H₁₄O₈
• 分子量: 334.282
• InChiKey: UMAASMUXEBOCLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  156
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,3-双(3,4-二甲氧基苯基)丁二酸 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以28%的产率得到2,3-双(3,4-二羟基苯基)丁二酸
  参考文献：
  名称：

  Catechol-Substituted l -Chicoric acid analogues as HIV integrase inhibitors

  摘要：

  HIV integrase catalyzes the integration of HIV DNA copy into the host cell DNA, which is essential for the production of progeny viruses. L-Chicoric acid and dicaffeoylquinic acids, isolated from plants, are well known potent inhibitors of HIV integrase. The common structural features of these inhibitors are caffeic acid derivatives connected to tartaric acid or quinic acid through ester bonds. In the present study, we have synthesized and tested the inhibitory activities of a new type of HIV IN inhibitors, which has catechol groups in place of caffeoyl groups in the structure of L-chicoric acid. Upon substitution of catechol groups at succinic acid, pyrrol dicarboxylic acid, maleimide or maleic anhydride, the inhibitory activities (IC50 = 3.8-23.6 muM) were retained or remarkably increased when compared to parent compound L-chicoric acid (IC50 = 13.7 muM). (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.09.046

文献信息

• Inadequate preanesthesia equipment checks in a simulator
  作者：Allysan Armstrong-Brown、J Hugh Devitt、Matt Kurrek、Marsha Cohen

  DOI：10.1007/bf03024868

  日期：2000.10

  Purpose: To assess how completely anesthesiologists check their machinery and equipment before use, and to determine what influence seniority age and type of practice may have on checking practices.Methods: One hundred and twenty anesthesiologists were videotaped during a simulated anesthesia session. Each participant was scored by an assessor according to the number of items checked prior to the induction of anesthesia. A checklist of 20 items derived from well-publicized, international standards was used.Results: Participants were grouped according to their type of practice. Overall, mean scores were low. The ideal score was 20. There were no differences among university anesthesiologists (mean score 10, 1, standard deviation 4.3), community anesthesiologists (7.5 +/- 4.3) and anesthesia residents (9.0 +/- 3.8), Each of these groups scored, on average, better than medical students (3.6 +/- 3.7) (P < 0.05). Neither age (r = 0.15, P > 0.1) nor number of years in practice (r = -0.18, P > 0.1) correlated with score.Conclusions: Our study suggests that the equipment-checking practices of anesthesiologists require considerable improvement when compared with national and international standards. Possible reasons for this are discussed and some remedial suggestions are made.
• Catechol-Substituted l -Chicoric acid analogues as HIV integrase inhibitors
  作者：Jae Yeol Lee、Kwon Joong Yoon、Yong Sup Lee

  DOI：10.1016/j.bmcl.2003.09.046

  日期：2003.12

  HIV integrase catalyzes the integration of HIV DNA copy into the host cell DNA, which is essential for the production of progeny viruses. L-Chicoric acid and dicaffeoylquinic acids, isolated from plants, are well known potent inhibitors of HIV integrase. The common structural features of these inhibitors are caffeic acid derivatives connected to tartaric acid or quinic acid through ester bonds. In the present study, we have synthesized and tested the inhibitory activities of a new type of HIV IN inhibitors, which has catechol groups in place of caffeoyl groups in the structure of L-chicoric acid. Upon substitution of catechol groups at succinic acid, pyrrol dicarboxylic acid, maleimide or maleic anhydride, the inhibitory activities (IC50 = 3.8-23.6 muM) were retained or remarkably increased when compared to parent compound L-chicoric acid (IC50 = 13.7 muM). (C) 2003 Elsevier Ltd. All rights reserved.