2,5-二氯-4-甲氧基苯酚 | 18113-14-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2,5-二氯-4-甲氧基苯酚
• 英文名称: 2,5-dichloro-4-methoxyphenol
• 英文别名: 2,5-Dichlor-4-methoxy-phenol
• CAS: 18113-14-9
• 化学式: C₇H₆Cl₂O₂
• 分子量: 193.029
• InChiKey: JXKFAPUUGWQXHX-UHFFFAOYSA-N

物化性质

• 保留指数：
  1399.9

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  四甲基甲烷二胺 、 2,5-二氯-4-甲氧基苯酚 生成
  参考文献：
  名称：

  Dimethylaminomethylation of phenols and α-naphthols

  摘要：

  DOI：

  10.1007/bf00761182
• 作为产物：
  描述：

  1,4-二氯-2-氯甲氧基-5-甲氧基-苯 在 硫酸 作用下， 生成 2,5-二氯-4-甲氧基苯酚
  参考文献：
  名称：

  Akerman et al., Journal of Applied Chemistry, 1953, vol. 3, p. 416

  摘要：

  DOI：

文献信息

• Synthesis of o-chlorophenols via an unexpected nucleophilic chlorination of quinone monoketals mediated by N,N′-dimethylhydrazine dihydrochloride
  作者：Zhiwei Yin、Jinzhu Zhang、Jing Wu、Riana Green、Sihan Li、Shengping Zheng

  DOI：10.1039/c4ob00391h

  日期：——

  An unexpected nucleophilic chlorination of a quinone monoketal while carrying out a pyrazolidine synthesis has led to a general preparation of multisubstituted phenols. The products are obtained in good to high yields under mild conditions. The bridged pyrazolidines that were the original targets are obtained in the presence of a protic solvent.

  在进行吡唑啉合成时，发生了一次意外的亲核氯化反应，导致了对醌单缩酮的多取代苯酚的一般制备。在温和条件下，产物以良好至高产率获得。在质子溶剂存在下，原本的桥连吡唑啉目标化合物也能得到。
• Efficient Coupling Reaction of Quinone Monoacetal with Phenols Leading to Phenol Biaryls
  作者：Tohru Kamitanaka、Koji Morimoto、Kohei Tsuboshima、Daichi Koseki、Hitoho Takamuro、Toshifumi Dohi、Yasuyuki Kita

  DOI：10.1002/anie.201608013

  日期：2016.12.12

  phenol biaryls by the cross‐couplings of quinone monoacetals (QMAs) and phenols is reported. The Brønsted acid catalytic system in 1,1,1,3,3,3‐hexafluoro‐2‐propanol was found to be particularly efficient for this transformation. This reaction can be extended to the synthesis of various phenol biaryls, including sterically hindered biaryls, with yields ranging from 58 to 90 % under mild reaction conditions

  据报道，通过醌单缩醛（QMA）和酚类的交叉偶联可以简单而有效地合成苯酚联芳基。发现在1,1,1,3,3,3-六氟-2-丙醇中的布朗斯台德酸催化体系对于这种转化特别有效。该反应可以扩展到各种苯酚联芳基的合成，包括空间位阻联芳基，在温和的反应条件下，以高度区域特异性的方式，收率范围为58％至90％。
• Antiviral activity of some .beta.-diketones. 1. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses
  作者：Guy D. Diana、U. Joseph Salvador、Ethel S. Zalay、Robert E. Johnson、Joseph C. Collins、David Johnson、William B. Hinshaw、Roman R. Lorenz、William H. Thielking、Francis Pancic

  DOI：10.1021/jm00216a003

  日期：1977.6

  The discovery that 4-[3-ethyl-6-[(3,4-methylenedioxy)phenyl]-3-hexenyl]-3,5-heptanedione (40) exhibited an in vitro inhibitory effect against equine rhinovirus led to a structure--activity study to establish the criteria for optimum activity. Modification of the bridge included removal of the ethyl group and reduction of the double bond. The heptanedione was replaced with hexanedione and pentanedione with a minimal effect. The effect of replacing the heptanedione with beta-keto esters and monoketones was also investigated. Maintaining the hexamethylene bridge and heptanedione, the methylenedioxy group was replaced with various substitutents. In general, most substituents did not adversely affect activity particularly against equine rhinovirus although there was some variation in activity against herpesvirus. Strongly hydrophilic groups significantly reduced activity. Finally, the effect of varying the length of the alkyl bridge was examined in the 4-hydroxyphenyl series, where peak activity was attained with n = 8.
• Reaction of Trialkyl Phosphites with p-Benzoquinone and with Other Symmetrically Substituted p-Quinones. A New Synthesis of Hydroquinone Monoalkyl Ethers^1,2
  作者：Fausto Ramirez、Eugene H. Chen、Samuel Dershowitz

  DOI：10.1021/ja01525a059

  日期：1959.8
• US4137273A
  申请人：——

  公开号：US4137273A

  公开（公告）日：1979-01-30

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