2,5-二甲基喹喔啉 | 26941-20-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2,5-二甲基喹喔啉
• 英文名称: 2,5-dimethylquinoxaline
• CAS: 26941-20-8
• 化学式: C₁₀H₁₀N₂
• mdl: MFCD18448735
• 分子量: 158.203
• InChiKey: GUZOJBWWSBCFRH-UHFFFAOYSA-N

物化性质

• 沸点：
  264.4±35.0 °C(Predicted)
• 密度：
  1.109±0.06 g/cm3(Predicted)
• LogP：
  2.595 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090

反应信息

• 作为产物：
  描述：

  N-acetonyl-6-methyl-2-nitro-N-p-tolylsulphonylaniline 在 盐酸 、 tin(ll) chloride 作用下， 以 溶剂黄146 为溶剂， 以15%的产率得到2,5-二甲基喹喔啉
  参考文献：
  名称：

  邻硝基苯胺衍生物。第8部分。一些不对称二甲基喹喔啉的合成：一个长期存在的问题得到解决

  摘要：

  的还原Ñ -acetonyl -4-甲基-2-硝基- ñ - p -tolylsulphonylaniline，使用锡（II在盐酸），氯化给出2,7- dimethylquinoxaline（42％）一起与二- p -甲苯基二硫化物和甲苯- p -硫醇。类似地，由适当取代的硝基苯胺获得2，6-和2，5-二甲基喹喔啉。然而，得到的2，8-二甲基异构体不纯且产率很低。

  DOI：

  10.1039/p19840000367

文献信息

• SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS
  申请人：GLAXOSMITHKLINE LLC

  公开号：US20150152108A1

  公开（公告）日：2015-06-04

  The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本发明涉及新型取代桥式脲化合物，相应的相关类似物，药物组合物以及其使用方法。本发明的抑制素调节化合物可用于延长细胞寿命，并治疗和/或预防各种疾病和疾病，包括但不限于与衰老或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块疾病、炎症、癌症和/或潮红有关的疾病或疾病，以及那些会受益于增加线粒体活性的疾病或疾病。本发明还涉及包含抑制素调节化合物与另一治疗剂组合的组合物。
• Effect of blocked ortho-positions on the cyclisation of aryl-1,4-diazabuta-1,3-dienyl radicals
  作者：Hamish McNab、Graeme S. Smith

  DOI：10.1039/c39820000996

  日期：——

  Indoles are the main products from the cyslisation of (2,6-dimethylpheneyl)-1,4-diazabuta-1,3-dienyl radicals, together with small amounts of quinoxalines; both ring systems arise predominantly via an intermediate spirodienyl radical.

  吲哚是（2,6-二甲基苯甲酰基）-1,4-重氮杂丁-1,3-二烯基与少量喹喔啉一起环化的主要产物；两个环系统主要通过中间螺二烯基产生。
• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• Manganese‐catalyzed Efficient Synthesis of <i>N</i>‐heterocycles and Aminoketones Using Glycerol as a C3 Synthon
  作者：Zeyuan Wei、Zhuofeng Ke、Yujie Wang、Qiang Liu

  DOI：10.1002/chem.202303481

  日期：2024.3.7

  Glycerol is one of the important biomass‐derived feedstocks and the high‐value utilizations of glycerol have attracted much attentions in recent years. Herein, we report a manganese catalyzed dehydrogenative coupling of glycerol with amines for the synthesis of substituted 2‐methylquinoxalines, 2‐ethylbenzimidazoles, and α‐aminoketones without any external oxidant. In these reactions, NHC‐based pincer manganese complex featuring a pyridine backbone displayed high catalytic activity and selectivity, in which hydrogen and water were produced as the only by‐products using glycerol as a C3 synthon.

  摘要甘油是重要的生物质原料之一，近年来甘油的高值化利用备受关注。在此，我们报告了一种锰催化的甘油与胺的脱氢偶联反应，该反应无需任何外部氧化剂即可合成取代的 2-甲基喹喔啉、2-乙基苯并咪唑和 α-氨基酮。在这些反应中，以吡啶为骨架的 NHC 型钳形锰络合物显示出很高的催化活性和选择性，以甘油为 C3 合成物产生的唯一副产物是氢和水。
• McNab, Hamish, Journal of the Chemical Society. Perkin transactions I, 1982, p. 357 - 364
  作者：McNab, Hamish

  DOI：——

  日期：——