2,5-二甲氧基-4-氨基二苯乙烯 | 23435-31-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 2,5-二甲氧基-4-氨基二苯乙烯
• 中文别名: 2,5-二甲氧基-4-[(E)-2-苯基乙烯基]苯胺
• 英文名称: 2,5-dimethoxy-4'-amino-trans-stilbene
• 英文别名: 4-amino-2',5'-dimethoxystilbene；trans-2,5-Dimethoxy-4'-aminostilben；4-[(E)-2-(2,5-dimethoxyphenyl)ethenyl]aniline
• CAS: 23435-31-6
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.316
• InChiKey: OZGXSMOLBWHIQA-ZZXKWVIFSA-N

物化性质

• 熔点：
  91-92 °C
• 沸点：
  398.54°C (rough estimate)
• 密度：
  1.0699 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  2,5-二甲氧基-4-氨基二苯乙烯 在 盐酸 、 sodium nitrite 作用下， 反应 0.5h， 生成 5-(4-(2-(2,5-dimethoxyphenyl)-ethenyl)phenylazo)-2-methoxy-2,4,6-cycloheptatrien-1-one
  参考文献：
  名称：

  Krieg, B.; Kuhn, T., Molecular Crystals and Liquid Crystals (1969-1991), 1987, vol. 145, p. 59 - 72

  摘要：

  DOI：
• 作为产物：
  描述：

  1,4-二甲氧基-2-乙烯基苯 、 对碘苯胺 在 四丁基溴化铵 、 potassium acetate 、 palladium diacetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以35%的产率得到2,5-二甲氧基-4-氨基二苯乙烯
  参考文献：
  名称：

  Design, synthesis, and biological evaluation of resveratrol analogues as aromatase and quinone reductase 2 inhibitors for chemoprevention of cancer

  摘要：

  A series of new resveratrol analogues were designed and synthesized and their inhibitory activities against aromatase were evaluated. The crystal structure of human aromatase (PDB 3eqm) was used to rationalize the mechanism of action of the aromatase inhibitor 32 (IC50 0.59 mu M) through docking, molecular mechanics energy minimization, and computer graphics molecular modeling, and the information was utilized to design several very potent inhibitors, including compounds 82 (IC50 70 nM) and 84 (IC50 36 nM). The aromatase inhibitory activities of these compounds are much more potent than that for the lead compound resveratrol, which has an IC50 of 80 mu M. In addition to aromatase inhibitory activity, compounds 32 and 44 also displayed potent QR2 inhibitory activity (IC50 1.7 mu M and 0.27 mu M, respectively) and the high-resolution X-ray structures of QR2 in complex with these two compounds provide insight into their mechanism of QR2 inhibition. The aromatase and quinone reductase inhibitors resulting from these studies have potential value in the treatment and prevention of cancer. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.05.042

文献信息

• Non-linear and potential non-linear optical materials containing molybdenum or tungsten mononitrosyl redox centres. Stilbene derivatives containing ferrocenyl, methoxy or dimethylamino donor groups
  作者：Benjamin J. Coe、Thomas A. Hamor、Christopher J. Jones、Jon A. McCleverty、David Bloor、Graham H. Cross、Tony L. Axon

  DOI：10.1039/dt9950000673

  日期：——

  Kurtz powder test for second harmonic generation (SHG). The ferrocenyl derivatives have been found to exhibit SHG on irradiation at 1907 nm, whereas all of the derivatives containing NMe2 or OMe groups are SHG inactive. The crystal structure of [Mo(NO)HB(dmpz)3}ClOC6H4[CHCHC6H4(NMe2-4)]-4}] shows that, although the compound crystallises in a polar space group, the lattice contains pseudocentrosymmetrically

  化合物[M（NO）HB（dmpz）3 } X n EC 6 H 4（CH CHC 6 H 3 –R，R'）-4} 2- n ]（dmpz = 3,5-二甲基吡唑基，n = 1，E = NH，R = [（η 5 -C 5 H ^ 4）的Fe（η 5 -C 5 H ^ 5）] - 4，R'= H; E = O，R = R'= H，E ＝ O或NH，R ＝ 4-OMe，R′＝ H； R ＝ 4-NMe 2，R′＝ H； E ＝ NH，R ＝ 2-OMe，R′＝ 4-OMe； R ＝ 3-OMe ，R'= 4-OMe； R = 2-OMe，R'= 5-OMe； M = Mo，X = Cl或I； M = W，X = Cl；n = 2； E = O，R = R ′= H; E = O或NH，R = 4-OMe或-NMe 2，R′＝ H；E = NH，R = 2-OMe，R'= 4-OMe; R ＝
• Pigment dispersant with hindered light amine stabilizer and pigment dispersions and coating compositions based thereon
  申请人：PPG Industries Ohio, Inc.

  公开号：US10557045B2

  公开（公告）日：2020-02-11

  A pigment dispersion is disclosed comprising (a) at least one pigment and (b) a polymeric dispersant comprising residual units derived from polymerization of a mixture of monomers comprising (b1) at least one ethylenically unsaturated hindered amine light stabilizing monomer and (b2) at least one additional ethylenically unsaturated monomer different from monomer (b1). Coating compositions comprising the same are also disclosed as are substrates coated at least in part with such coatings.

  本发明公开了一种颜料分散剂，包括(a)至少一种颜料和(b)聚合物分散剂，聚合物分散剂由单体混合物聚合产生的残留单元组成，单体混合物包括(b1)至少一种乙烯基不饱和受阻胺光稳定单体和(b2)至少一种不同于单体(b1)的额外乙烯基不饱和单体。此外，还公开了包含上述成分的涂层组合物，以及至少部分涂有此类涂层的基材。
• Ethylenically unsaturated amine salts of sulfonic, phosphoric, and carboxylic acids
  申请人：Stepan Company

  公开号：US20010018461A1

  公开（公告）日：2001-08-30

  Disclosed are ethylenically unsaturated amine salts of sulfonic, phosphoric and carboxylic acids. The salts are surface active agents which are useful in a variety of applications as primary and/or secondary surfactants. The salts are especially useful as surfactants in emulsion polymerization reactions.

  本发明公开了磺酸、磷酸和羧酸的乙烯不饱和胺盐。这些盐类是表面活性剂，在各种应用中可用作一级和/或二级表面活性剂。这些盐在乳液聚合反应中作为表面活性剂尤其有用。
• Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealant, adhesives and elastomers produced from such latexes
  申请人：Stepan Company

  公开号：US20020040092A1

  公开（公告）日：2002-04-04

  Disclosed are antibacterial CASE materials comprising a latex comprising polymer particles and a surfactant component. Also disclosed are components and methods for forming such materials.

  所公开的抗菌 CASE 材料由包含聚合物颗粒和表面活性剂成分的胶乳组成。还公开了形成这种材料的成分和方法。
• Emulsion polymerization process utilizing ethylenically unsaturated amine salts of sulfonic, phosphoric and carboxylic acids
  申请人：STEPAN COMPANY, A corporation of the State of Delaware

  公开号：US20020161108A1

  公开（公告）日：2002-10-31

  Disclosed is an improved method of making polymers. The method utilizes at least one ethylenically unsaturated monomer and at least one polymerizable surface active agent. The polymerizable surface active agent is capable of co-polymerization with traditional monomers and/or polymerization with itself (i.e. homopolymerization) and is preferably substantially completely consumed during the course of the polymerization. Polymers produced by the method of the present invention are well suited for use in coatings, adhesives, sealants, elastomers and the like, as they form stable films, possess excellent adhesion properties and have improved hydrolytic stability characteristics. The present invention also encompasses homopolymeric surface active agents and their use in polymerization reactions.

  本发明公开了一种改进的聚合物制造方法。该方法利用至少一种乙烯基不饱和单体和至少一种可聚合表面活性剂。可聚合表面活性剂能与传统单体共聚合和/或与自身聚合（即均聚），最好在聚合过程中完全消耗。用本发明的方法生产的聚合物非常适合用于涂料、粘合剂、密封剂、弹性体等，因为它们能形成稳定的薄膜，具有优异的粘合性能和更好的水解稳定性。本发明还包括均聚物表面活性剂及其在聚合反应中的应用。

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