2,6-二氧代-2,3-二氢-1H-嘌呤-9(6H)-羧酸 | 71965-22-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 2,6-二氧代-2,3-二氢-1H-嘌呤-9(6H)-羧酸
• 英文名称: 1,2,3,6-Tetrahydro-2,6-dioxo-9H-purine-9-carboxylic acid
• 英文别名: 2,6-dioxo-3H-purine-9-carboxylic acid
• CAS: 71965-22-5
• 化学式: C₆H₄N₄O₄
• 分子量: 196.12
• InChiKey: WKBPMGCUQROFFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2933990090

文献信息

• Xanthene derivatives
  申请人：——

  公开号：US20040054195A1

  公开（公告）日：2004-03-18

  Secondary amide xanthene derivatives, termed “xanthamides”, and other xanthene derivatives, are obtained in one form as fluorescent dyes which can have much higher photostability than related dyes such as fluorescein and BODIPY-FL. Examples are presented in which the synthesis begins with 5-carboxyfluorescein, an inexpensive reagent. Related carboxyxanthenes employed in other dyes such as rhodamines can also be used as starting materials. Simple synthetic steps yield compounds which exemplify this invention. Other notable properties of the xanthamide dyes include the option of pH-independent fluorescence, and the ease of controlling their functional and other groups. This means that a diversity of xanthamide and related xanthene dyes can be prepared with a broad variation of physicochemical properties to enhance the usefulness of fluorescence in biological and chemical analysis, and in other areas. In a second form xanthamides are formed which can be used as precursors of xanthamide dyes, especially as indicators or quenchers of reactive oxygen or free radical species.

  二级酰胺黄素衍生物，称为“黄酰胺”，以及其他黄素衍生物，以一种形式获得，作为荧光染料，其光稳定性可以比相关染料如荧光素和BODIPY-FL高得多。其中一些示例是以5-羧基荧光素开始合成的，这是一种廉价试剂。其他用于制备其他染料（如罗丹明）的相关羧基黄素也可以用作起始材料。简单的合成步骤产生了代表这种发明的化合物。黄酰胺染料的其他显着特性包括无pH依赖性荧光的选择，以及控制其功能和其他基团的易于性。这意味着可以准备各种具有广泛物理化学性质变化的黄酰胺和相关黄素染料，以增强在生物和化学分析以及其他领域中荧光的有用性。在第二种形式中，形成了可以用作黄酰胺染料的前体的黄酰胺，特别是作为反应性氧或自由基物种的指示剂或猝灭剂。
• PREVENTIVES/REMEDIES FOR GRANULOMA
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1297848A1

  公开（公告）日：2003-04-02

  A preventive or therapeutic agent for granuloma, specifically for granuloma occurring after ligation of a deferent duct, comprising an antagonist against the scavenger receptor of macrophage, such as antibody, as an active ingredient.

  一种预防或治疗肉芽肿的药物，特别适用于输精管结扎后发生的肉芽肿，其有效成分包括针对巨噬细胞清道夫受体的拮抗剂，如抗体。
• Preventives/remedies for granuloma
  申请人：——

  公开号：US20030171323A1

  公开（公告）日：2003-09-11

  A preventive or therapeutic agent for granuloma, specifically for granuloma occurring after ligation of a deferent duct, comprising an antagonist against the scavenger receptor of macrophage, such as antibody, as an active ingredient.

  一种预防或治疗肉芽肿的药物，特别适用于输精管结扎后发生的肉芽肿，其有效成分包括针对巨噬细胞清道夫受体的拮抗剂，如抗体。
• US3993767A
  申请人：——

  公开号：US3993767A

  公开（公告）日：1976-11-23
• [EN] PHARMACEUTICAL COMPOSITIONS CONTAINING AN OLIGONUCLEOTIDE AND AN ANIONIC POLYSACCHARIDE<br/>[FR] COMPOSITIONS PHARMACEUTIQUES CONTENANT UN OLIGONUCLEOTIDE ET UN POLYSACCHARIDE ANIONIQUE
  申请人：NOVARTIS AG

  公开号：WO1997010829A1

  公开（公告）日：1997-03-27

  (EN) A pharmaceutical composition comprising (A) an oligonucleotide and (B) an anionic polysaccharide such as dextran sulphate which can be used in the treatment of mammalian cancer.(FR) Composition pharmaceutique comprenant A) un oligonucléotide et B) un polysaccharide anionique tel que le sulfate de dextrane et utilisable pour le traitement du cancer chez les mammifères.