2,8-二甲基喹喔啉 | 81576-25-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2,8-二甲基喹喔啉
• 中文别名: 6-[3-(二甲氨基)丙基]-6,12-二氢-苯并呋喃并[3,2-c][1]苯并噁庚-6-醇
• 英文名称: 2,8-dimethylquinoxaline
• CAS: 81576-25-2
• 化学式: C₁₀H₁₀N₂
• 分子量: 158.203
• InChiKey: QBIHDKFNULRSQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丙酮醛 、 2,3-二氨基甲苯 在 sodium hydrogensulfite 作用下， 生成 2,5-二甲基喹喔啉 、 2,8-二甲基喹喔啉
  参考文献：
  名称：

  McNab, Hamish, Journal of the Chemical Society. Perkin transactions I, 1982, p. 357 - 364

  摘要：

  DOI：

文献信息

• Effect of blocked ortho-positions on the cyclisation of aryl-1,4-diazabuta-1,3-dienyl radicals
  作者：Hamish McNab、Graeme S. Smith

  DOI：10.1039/c39820000996

  日期：——

  Indoles are the main products from the cyslisation of (2,6-dimethylpheneyl)-1,4-diazabuta-1,3-dienyl radicals, together with small amounts of quinoxalines; both ring systems arise predominantly via an intermediate spirodienyl radical.

  吲哚是（2,6-二甲基苯甲酰基）-1,4-重氮杂丁-1,3-二烯基与少量喹喔啉一起环化的主要产物；两个环系统主要通过中间螺二烯基产生。
• NEW POLYMER AND POLYMER LIGHT-EMITTING DEVICE USING THE SAME
  申请人：Kobayashi Satoshi

  公开号：US20080103278A1

  公开（公告）日：2008-05-01

  Provided is a polymer comprising a repeating unit represented by formula (1), wherein, A 1 represents a divalent group in which the bond distance ratio (bond distance of C(α)-A 1 /bond distance of C(α)-C(β)) is 1.10 or more; R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , each independently represent a hydrogen atom, alkyl group, alkyloxy group, aryloxy group, arylalkyloxy group, etc. The polymer is useful as a light-emitting material, a charge transporting material, etc.

  提供的是一种聚合物，其中包含由式（1）表示的重复单元，其中A1表示具有结合距离比（C（α）-A1的结合距离/C（α）-C（β）的结合距离）为1.10或更多的二价基团；R1、R2、R3、R4、R5和R6各自独立地表示氢原子、烷基、烷氧基、芳氧基、芳基烷氧基等。该聚合物可用作发光材料、电荷传输材料等。
• POLYMER COMPOUND CONTAINING NITROGEN-CONTAINING HETEROCYCLIC STRUCTURE, AND COMPOSITION, SOLUTION, THIN FILM AND POLYMER LIGHT-EMITTING ELEMENT EACH CONTAINING SAME
  申请人：Ishii Yusuke

  公开号：US20110210322A1

  公开（公告）日：2011-09-01

  A polymer compound having a repeating unit represented by formula (1-0): wherein in formula (1-0), ring A 01 and ring A 02 are the same or different and each represents an aromatic hydrocarbon ring that is optionally substituted; and X 10 and X 20 are the same or different and each represents a hydrogen atom or a substituent, provided that at least one of X 10 and X 20 is a group represented by formula (2-0): wherein in formula (2-0), Z 10 , Z 20 and Z 30 are the same or different and each represents —N═ or —CH═, provided that at least two of Z 10 , Z 20 and Z 30 are —N═; L 0 represents an arylene group or a single bond; and Ar 10 and Ar 20 are the same or different and each represents an aryl group, provided that the total carbon number of the groups represented by Ar 10 , Ar 20 and L 0 is 24 or more.

  具有由公式（1-0）表示的重复单元的聚合物化合物：其中，在公式（1-0）中，环A01和环A02相同或不同，每个环都表示可以选择取代的芳香族碳氢环；X10和X20相同或不同，每个都表示氢原子或取代基，但至少其中一个是由公式（2-0）表示的基团：其中，在公式（2-0）中，Z10、Z20和Z30相同或不同，每个都表示—N═或—CH═，但至少有两个是—N═；L0表示芳撑基团或单键；Ar10和Ar20相同或不同，每个都表示芳基团，但由Ar10、Ar20和L0表示的基团的总碳数为24或更多。
• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• Manganese‐catalyzed Efficient Synthesis of <i>N</i>‐heterocycles and Aminoketones Using Glycerol as a C3 Synthon
  作者：Zeyuan Wei、Zhuofeng Ke、Yujie Wang、Qiang Liu

  DOI：10.1002/chem.202303481

  日期：2024.3.7

  Glycerol is one of the important biomass‐derived feedstocks and the high‐value utilizations of glycerol have attracted much attentions in recent years. Herein, we report a manganese catalyzed dehydrogenative coupling of glycerol with amines for the synthesis of substituted 2‐methylquinoxalines, 2‐ethylbenzimidazoles, and α‐aminoketones without any external oxidant. In these reactions, NHC‐based pincer manganese complex featuring a pyridine backbone displayed high catalytic activity and selectivity, in which hydrogen and water were produced as the only by‐products using glycerol as a C3 synthon.

  摘要甘油是重要的生物质原料之一，近年来甘油的高值化利用备受关注。在此，我们报告了一种锰催化的甘油与胺的脱氢偶联反应，该反应无需任何外部氧化剂即可合成取代的 2-甲基喹喔啉、2-乙基苯并咪唑和 α-氨基酮。在这些反应中，以吡啶为骨架的 NHC 型钳形锰络合物显示出很高的催化活性和选择性，以甘油为 C3 合成物产生的唯一副产物是氢和水。