2-(2-喹喔啉基)乙醇 | 30093-23-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 2-(2-喹喔啉基)乙醇
• 英文名称: <2-(2'-hydroxyethyl)quinoxaline>
• 英文别名: 2-(2'-hydroxyethyl)quinoxaline；2-quinoxalin-2-yl-ethanol；2-<2-Hydroxy-aethyl>-chinoxalin；2-(Quinoxalin-2-YL)ethanol；2-quinoxalin-2-ylethanol
• CAS: 30093-23-3
• 化学式: C₁₀H₁₀N₂O
• 分子量: 174.202
• InChiKey: IBGYOCWSEXZTCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  2-(2-喹喔啉基)乙醇 在 吡啶 、 三甲基乙酰氯 、 三氟乙酸 作用下， 以 氯仿 为溶剂， 反应 2.0h， 生成 N²-isobutyryl-2'-deoxyguanosine-3'-[H-phosphono-2''-(O-hydroxyethyl)quinoxaline]
  参考文献：
  名称：

  On the chemistry of RNA degradation by Fe·bleomycin

  摘要：

  The chemistry of RNA degradation by Fe bleomycin was studied using two RNA substrates that are modified efficiently at a small number of sites by the antitumor antibiotic. Cleavage of a tRNA(His) precursor transcript by Fe(II).BLM A(2) was shown to require O-2; cleavage was also observed when the same substrate was treated with Fe(III).BLM A(2) + H2O2. Consistent with earlier observations made for DNA, the extent of tRNA(His) precursor cleavage was greater for Fe(II).BLM A(5), than for Fe(II).BLM A(2); the least cleavage was obtained using Fe(II).BLM demethyl A(2). By the use of a P-32 end labeled tRNA precursor transcript that was also H-3 labeled within the uracil moieties, it was shown that release of uracil was nearly stoichiometric with tRNA strand scission by Fe(II).BLM A(2). Nonetheless, treatment of the tRNA(His) with hydrazine following BLM-mediated cleavage indicated formation of a new product that must have derived from a BLM-induced lesion. Also employed far characterization of BLM cleavage of RNA were the octanucleotides CGCTAGCG, C-3-ribo-CGCTAGCG and C-3-ara-CGCTAGCG. Analysis of the products of cleavage indicates that Fe . BLM is capable of mediating cleavage by abstraction of a H atom either from C-4'H or C-1'H of the chimeric oligonucleotides. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0968-0896(97)00038-2
• 作为产物：
  描述：

  D-吡喃葡萄糖醛酸 生成 2-(2-喹喔啉基)乙醇
  参考文献：
  名称：

  MORITA, NAOFUMI;NAKATA, KUNIHIKO;TAKAGI, MASANOSUKE, AGR. AND BIOL. CHEM., 53,(1989) N, C. 437-442

  摘要：

  DOI：

文献信息

• Degradation of Glucose: Reinvestigation of Reactive α-Dicarbonyl Compounds^†
  作者：Jenny Gobert、Marcus A. Glomb

  DOI：10.1021/jf9019085

  日期：2009.9.23

  to give stable quinoxalines of d-arabino-hexos-2-ulose (glucosone), N6-(3,6-dideoxyhexos-2-ulos-6-yl)-l-lysine, 1-deoxy-d-erythro-2,3-hexodiulose (1-deoxyglucosone), 3-deoxy-d-erythro-hexos-2-ulose (3-deoxyglucosone), ethanedial (glyoxal), 2-oxopropanal (methylglyoxal), 3,4-dihydroxy-2-oxobutanal (threosone), 1-hydroxy-2,3-butanedione (1-deoxythreosone), 4-hydroxy-2-oxobutanal (3-deoxythreosone), 4,

  美拉德反应以重要方式影响加工食品中风味和颜色的形成。还原糖和氨基酸最终会与稳定的最终产物发生反应。为了阐明复杂的形成途径，已经发表了大量实验。α-二羰基化合物被认为是重要的关键中间体。在目前的工作中，对赖氨酸存在下的美拉德葡萄糖降解进行了重新研究。用邻苯二胺捕获α-二羰基化合物，得到稳定的d-阿拉伯-己基-2-己糖（葡糖酮），N 6-（3,6-二脱氧己基-2-ulos-6-基）-1-赖氨酸的喹喔啉，1-deoxy- d - erythro-2,3-己二糖（1-脱氧葡糖酮），3- deoxy- d-赤-己基-2-ulose（3-脱氧葡糖酮），乙二醛（乙二醛），2-氧丙醛（甲基乙二醛），3,4-二羟基-2 -oxobutanal（苏糖松），1-hydroxy-2,3-butanedione（1-deoxythreosone），4-hydroxy-2-oxobutanal（3-deoxythreosone），4
• Morita, Naofumi; Nakata, Kunihiko; Takagi, Masanosuke, Agricultural and Biological Chemistry, 1989, vol. 53, # 2, p. 437 - 442
  作者：Morita, Naofumi、Nakata, Kunihiko、Takagi, Masanosuke

  DOI：——

  日期：——
• TAKAGI, MASANOSUKE;DAIDO, YOSHIYUKI;KURIYAMA, MASAO;MORITA, NAOFUMI, ANAL. SCI., 6,(1990) N, C. 529-534
  作者：TAKAGI, MASANOSUKE、DAIDO, YOSHIYUKI、KURIYAMA, MASAO、MORITA, NAOFUMI

  DOI：——

  日期：——
• ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 1-BENZOPYRAN-4-ONES AND 2-AMINO-1,3-BENZOXAZINE-4-ONES
  申请人：THE UPJOHN COMPANY

  公开号：EP0459983A1

  公开（公告）日：1991-12-11
• ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 2-AMINO-6-PHENYL-4H-PYRAN-4-ONES
  申请人：THE UPJOHN COMPANY

  公开号：EP0489877B1

  公开（公告）日：1995-09-20