Theophylline acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Theophylline acetate
• 英文别名: acetic acid;1,3-dimethyl-7H-purine-2,6-dione
• 化学式: C9H12N4O4
• 分子量: 240.22
• InChiKey: VYEYJCBEXFTGBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.95
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  107
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Imidazole derivatives as PDE10A enzyme inhibitors
  申请人：Kehler Jan

  公开号：US20120129836A1

  公开（公告）日：2012-05-24

  This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

  这项发明涉及一类PDE10A酶抑制剂化合物。该发明提供了一种包含该发明化合物的治疗有效量和药用载体的药物组合物。本发明还提供了制备式I化合物的方法。本发明还提供了一种治疗神经退行性疾病的方法，包括向患有神经退行性疾病的受试者施用式I化合物的治疗有效量。本发明还提供了一种治疗药物成瘾的方法，包括向患有药物成瘾的受试者施用式I化合物的治疗有效量。本发明还提供了一种治疗精神障碍的方法，包括向患有精神障碍的受试者施用式I化合物的治疗有效量。
• Therapeutic Uses Of Compounds Having Affinity To The Serotonin Transporter, Serotonin Receptors And Noradrenalin Transporter
  申请人：H. Lundbeck A/S

  公开号：US20170087138A1

  公开（公告）日：2017-03-30

  Therapeutic uses of 4-[2-(4-methylphenylsulfanyl)phenyl]piperidine and therapeutically acceptable salts thereof are provide.

  4-[2-(4-甲基苯基硫基)苯基]哌啶及其治疗上可接受的盐的治疗用途已提供。
• [EN] TRIAZOLOPYRAZINE DERIVATIVES AND THEIR USE FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS<br/>[FR] DÉRIVÉS DE TRIAZOLOPYRAZINE ET LEUR UTILISATION POUR LE TRAITEMENT DE TROUBLES NEUROLOGIQUES ET PSYCHIATRIQUES
  申请人：LUNDBECK & CO AS H

  公开号：WO2013034755A1

  公开（公告）日：2013-03-14

  The present invention is directed to triazolopyrazine compounds of Formula (I). Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds as therapeutic agents treating neurological and psychiatric disorders.

  本发明涉及式(I)的三唑吡嗪化合物。该发明的不同方面涉及包含所述化合物的药物组合物以及将该化合物用作治疗神经系统和精神疾病的治疗剂的用途。
• Benzamides
  申请人：H. Lundbeck A/S

  公开号：US20140107340A1

  公开（公告）日：2014-04-17

  The present invention is directed to benzamide containing compounds which inhibit the P2X7 receptor

  本发明涉及含有抑制P2X7受体的苯甲酰胺类化合物。
• [EN] PYRIDINYL DERIVATIVES AS INHIBITORS OF ENZYME NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE<br/>[FR] DÉRIVÉS DE PYRIDINYLE UTILISÉS EN TANT QU'INHIBITEURS DE L'ENZYME NICOTINAMIDE PHOSPHORIBOSYLTRANSFÉRASE
  申请人：TOPOTARGET AS

  公开号：WO2010142735A1

  公开（公告）日：2010-12-16

  The present application discloses a compound of the formula (I) wherein Q is optionally substituted pyridyl; p is 0-6; Y is formulae (i), (ii) and (iii) where X is =O, =S and =N-CN, r is 1-12, R is -Z-A, Z is a single bond, -S(=O)2-, >P=O, >C=O, -C(=O)NH-, and -C(=S)NH-; and A is hydrogen, C1-12-alkyl, C3-12-cycloalkyl, - [CH2CH2O]1-10-(C1-6-alkyl), C1-12-alkenyl, aryl, heterocyclyl, and heteroaryl; B is a single bond, -NRN-, -S(=O)2- and -O-; wherein RN is selected from hydrogen, C1-12-alkyl, C3-12-cycloalkyl, -[CH2CH2O]1-10-(C1-6-alkyl), C1-12-alkenyl, aryl, heterocyclyl, and heteroaryl; s is 0-6; and Cy is aryl, cycloalkyl, heterocyclyl, and heteroaryl. The compounds are usefuld for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT).

  本申请公开了一种化合物，其化学式为（I），其中Q是可选择取代的吡啶基；p为0-6；Y是式（i）、（ii）和（iii），其中X为=O、=S和=N-CN，r为1-12，R为-Z-A，Z为单键，-S(=O)2-，>P=O，>C=O，-C(=O)NH-和-C(=S)NH-；A为氢、C1-12-烷基、C3-12-环烷基、-[CH2CH2O]1-10-(C1-6-烷基)、C1-12-烯基、芳基、杂环烷基和杂芳基；B为单键，-NRN-，-S(=O)2-和-O-；其中RN从氢、C1-12-烷基、C3-12-环烷基、-[CH2CH2O]1-10-(C1-6-烷基)、C1-12-烯基、芳基、杂环烷基和杂芳基中选择；s为0-6；Cy为芳基、环烷基、杂环烷基和杂芳基。这些化合物可用作治疗由烟酰胺磷酸核糖转移酶（NAMPRT）水平升高引起的疾病或症状的药物。