3-Propyl-6-trifluoromethyl-4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide | 293316-11-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3-Propyl-6-trifluoromethyl-4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide
• 英文别名: 1,1-dioxo-3-propyl-6-(trifluoromethyl)-4H-1λ6,4-benzothiazine-2-carbonitrile
• CAS: 293316-11-7
• 化学式: C₁₃H₁₁F₃N₂O₂S
• 分子量: 316.304
• InChiKey: SFVZSILUCSIYFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-(2-Cyanomethylsulfonyl-5-trifluoromethylphenyl)butyramide 在 盐酸 作用下， 以 sodium hydroxide 为溶剂， 以0.33 g (85%)的产率得到3-Propyl-6-trifluoromethyl-4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide
  参考文献：
  名称：

  Fused 1,4-thiazine-2-carbonitrile derivatives, their preparation and use

  摘要：

  本发明涉及融合的1,4-噻嗪-2-碳腈衍生物，其组合物以及制备这些化合物的方法。这些化合物在治疗中枢神经系统、心血管系统、呼吸系统、消化系统和内分泌系统疾病方面具有用途。

  公开号：

  US06232310B1

文献信息

• Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels
  申请人：Herlands Louis

  公开号：US20070026079A1

  公开（公告）日：2007-02-01

  Provided are methods of increasing K ATP channel activity in the hypothalamus of a mammal, methods of reducing glucose production in a mammal, methods of reducing peripheral glucose levels in a mammal, methods of reducing triglyceride levels in a mammal, methods of reducing very low density lipoprotein (VLDL) levels in a mammal, methods of methods of reducing gluconeogenesis in the liver of a mammal, methods of treating metabolic disorders such as diabetes, hyperglycemia, insulin resistance, glucose intolerance, metabolic syndrome and/or obesity, and methods of increasing glucose production and peripheral glucose levels in a mammal. Also provided are methods of treating heart failure, ischemia, coronary heart disease, familial lipoprotein lipase deficiency, hypopituitarism, hyperlipidemia, hypertriglyceridemia, hyperVLDLemia, atherosclerosis, hypercholesterolemia, hypertension, polycystic ovary syndrome, gonadotropin deficiency and/or amenorrhea.
• Modulation of Hypothalamic Atp-Sensitive Potassium Channels
  申请人：Rossetti Luciano

  公开号：US20090012067A1

  公开（公告）日：2009-01-08

  Provided are methods of increasing K ATP activity in the hypothalamus of a mammal, methods of reducing glucose production and peripheral blood glucose levels in a mammal, methods of inhibiting gluconeogenesis in the liver of a mammal, and methods of increasing glucose production and peripheral blood glucose levels in a mammal.
• US6232310B1
  申请人：——

  公开号：US6232310B1

  公开（公告）日：2001-05-15
• Fused 1,4-thiazine-2-carbonitrile derivatives, their preparation and use
  申请人：Novo Nordisk A/S

  公开号：US06232310B1

  公开（公告）日：2001-05-15

  The present invention relates to fused 1,4-thiazine-2-carbonitrile derivatives, compositions thereof and methods for preparing the compounds. The compounds are useful in the treatment of diseases of the central nervous system, the cardiovascular system, the pulmonary system, the gastrointestinal system and the endocrinological system.

  本发明涉及融合的1,4-噻嗪-2-碳腈衍生物，其组合物以及制备这些化合物的方法。这些化合物在治疗中枢神经系统、心血管系统、呼吸系统、消化系统和内分泌系统疾病方面具有用途。