3-Propyl-6-trifluoromethyl-4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide | 293316-11-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3-Propyl-6-trifluoromethyl-4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide
• 英文别名: 1,1-dioxo-3-propyl-6-(trifluoromethyl)-4H-1λ6,4-benzothiazine-2-carbonitrile
• CAS: 293316-11-7
• 化学式: C₁₃H₁₁F₃N₂O₂S
• 分子量: 316.304
• InChiKey: SFVZSILUCSIYFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  78.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-(2-Cyanomethylsulfonyl-5-trifluoromethylphenyl)butyramide 在 盐酸 作用下， 以 sodium hydroxide 为溶剂， 以0.33 g (85%)的产率得到3-Propyl-6-trifluoromethyl-4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide
  参考文献：
  名称：

  Fused 1,4-thiazine-2-carbonitrile derivatives, their preparation and use

  摘要：

  本发明涉及融合的1,4-噻嗪-2-碳腈衍生物，其组合物以及制备这些化合物的方法。这些化合物在治疗中枢神经系统、心血管系统、呼吸系统、消化系统和内分泌系统疾病方面具有用途。

  公开号：

  US06232310B1

文献信息

• Intranasal administration of modulators of hypothalamic ATP-sensitive potassium channels
  申请人：Herlands Louis

  公开号：US20070026079A1

  公开（公告）日：2007-02-01

  Provided are methods of increasing K ATP channel activity in the hypothalamus of a mammal, methods of reducing glucose production in a mammal, methods of reducing peripheral glucose levels in a mammal, methods of reducing triglyceride levels in a mammal, methods of reducing very low density lipoprotein (VLDL) levels in a mammal, methods of methods of reducing gluconeogenesis in the liver of a mammal, methods of treating metabolic disorders such as diabetes, hyperglycemia, insulin resistance, glucose intolerance, metabolic syndrome and/or obesity, and methods of increasing glucose production and peripheral glucose levels in a mammal. Also provided are methods of treating heart failure, ischemia, coronary heart disease, familial lipoprotein lipase deficiency, hypopituitarism, hyperlipidemia, hypertriglyceridemia, hyperVLDLemia, atherosclerosis, hypercholesterolemia, hypertension, polycystic ovary syndrome, gonadotropin deficiency and/or amenorrhea.
• Modulation of Hypothalamic Atp-Sensitive Potassium Channels
  申请人：Rossetti Luciano

  公开号：US20090012067A1

  公开（公告）日：2009-01-08

  Provided are methods of increasing K ATP activity in the hypothalamus of a mammal, methods of reducing glucose production and peripheral blood glucose levels in a mammal, methods of inhibiting gluconeogenesis in the liver of a mammal, and methods of increasing glucose production and peripheral blood glucose levels in a mammal.
• US6232310B1
  申请人：——

  公开号：US6232310B1

  公开（公告）日：2001-05-15