2-(2-羟乙氨基)-2-羟甲基-1,3-丙二醇 | 7343-51-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(2-羟乙氨基)-2-羟甲基-1,3-丙二醇
• 英文名称: 2-(2-hydroxy-ethylamino)-2-hydroxymethyl-propane-1,3-diol
• 英文别名: (2-Hydroxy-aethyl)-(β.β'.β''-trihydroxy-tert.-butyl)-amin；2-(2-Hydroxy-aethylamino)-2-hydroxymethyl-propan-1,3-diol；(2-Hydroxy-aethylamino)-tris-hydroxymethyl-methan；N-(2-hydroxyethyl) amino tris (hydroxymethyl) methane；2-((2-Hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diol；2-(2-hydroxyethylamino)-2-(hydroxymethyl)propane-1,3-diol
• CAS: 7343-51-3
• 化学式: C₆H₁₅NO₄
• 分子量: 165.189
• InChiKey: OTWJRAWXTDGSDT-UHFFFAOYSA-N

物化性质

• 熔点：
  89 °C
• 沸点：
  411.3±40.0 °C(Predicted)
• 密度：
  1.306±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  在常温常压下保持稳定，应避免与不相容的材料接触。

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  93
• 氢给体数：
  5
• 氢受体数：
  5

安全信息

• 储存条件：
  密封储存，应存放在阴凉、干燥的库房中，并禁止存放于铝制或铜制容器内。

SDS

Name:	2-(2-Hydroxyethylamino)-2-(hydroxymethyl)- 1,3-propanediol, 99% Material Safety Data Sheet
Synonym:	1,3-Propanediol, 2-(2-hydroxyethyl)amino-2-hydroxymethyl)-
CAS:	7343-51-3

Section 1 - Chemical Product MSDS Name: 2-(2-Hydroxyethylamino)-2-(hydroxymethyl)- 1,3-propanediol, 99% Material Safety Data Sheet
Synonym: 1,3-Propanediol, 2-(2-hydroxyethyl)amino-2-hydroxymethyl)-

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SECTION 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
7343-51-3	2-(2-Hydroxyethylamino)-2-(hydroxymeht	99	230-862-5

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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SECTION 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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SECTION 4 - FIRST AID MEASURES
Eyes:
Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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SECTION 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam.

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SECTION 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

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SECTION 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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SECTION 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 7343-51-3: Personal Protective Equipment
Eyes:
Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.

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SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 89 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C6H15NO4
Molecular Weight: 165.19

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SECTION 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, strong oxidants.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Irritating and toxic fumes and gases.
Hazardous Polymerization: Has not been reported

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SECTION 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 7343-51-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-(2-Hydroxyethylamino)-2-(hydroxymehtyl-1,3-propanediol - Not listed by ACGIH, IARC, or NTP.

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SECTION 12 - ECOLOGICAL INFORMATION

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SECTION 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations.

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SECTION 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material.

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SECTION 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases: S 24/25 Avoid contact with skin and eyes. S 28A After contact with skin, wash immediately with plenty of water. S 37 Wear suitable gloves. S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). WGK (Water Danger/Protection) CAS# 7343-51-3: No information available. Canada CAS# 7343-51-3 is listed on Canada's NDSL List. CAS# 7343-51-3 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 7343-51-3 is listed on the TSCA inventory.

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SECTION 16 - ADDITIONAL INFORMATION
MSDS Creation Date: 12/26/1998 Revision #2 Date: 3/18/2003 The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no way shall the company be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if the company has been advised of the possibility of such damages.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为产物：
  描述：

  环氧乙烷 、 三羟甲基氨基甲烷 以 水 为溶剂， 反应 5.0h， 以80%的产率得到2-(2-羟乙氨基)-2-羟甲基-1,3-丙二醇
  参考文献：
  名称：

  多齿氨基醇的钒 (V) 配合物：微调配合物的特性

  摘要：

  在水溶液中，测定了 12 种钒 (V) 配合物的稳定性、结构和不稳定性，并与氨基醇配体的性质有关。选择氨基醇以保持钒络合物中的五配位钒几何形状，并且基于二乙醇胺作为母体配体。确定了所有 12 种复合物的表观和复合稳定性常数。进一步检查选定的复合物以确定溶液结构、不稳定性和热力学性质。我们凭经验表明，当绘制为质子化氨基醇 pKa 值的函数时，12 种复合物系列的形成常数会生成一条曲线，该曲线最初随着 pKa 值的增加而增加，然后随着 pKa 值的继续增加而减小. 观察到的关联表明氨基醇的给电子能力在复合物稳定性中起主要作用；然而，金属配位数、氨基醇中的空间位阻和溶剂化也...

  DOI：

  10.1021/ja9808200

文献信息

• Injectable rabies vaccine composition and method for preparing same
  申请人：SCHERING CORPORATION

  公开号：EP0049296A1

  公开（公告）日：1982-04-14

  An injectable rabies vaccine composition is disclosed which comprises a sterilized suspension of a minor concentration by weight of proteineous suckling mice or rat brain particles of injectable particle size laden with inactivated rabies virus in an aqueous buffer solution having a slightly basic pH-value and an amount, dissolved therein, of a buffer composition sufficient to stabilize the pH at said value, said buffer composition comprising a mixture of an organic base of the formula wherein R1 and R2 each are hydrogen or CH2CH20H and an acid addition salt thereof, preferably a mixture of tris (hydroxymethyl)amino methane and its hydrochloride. Also a process for preparing said vaccine composition is disclosed. The vaccine composition exhibits a high potency and its pH value remains stable over a prolonged period of time.

  本发明公开了一种可注射的狂犬病疫苗组合物，该组合物包括在具有微碱性 pH 值的缓冲水溶液中，以重量计，含有灭活狂犬病病毒的可注射粒度的蛋白乳鼠或大鼠脑颗粒的微量浓度的灭菌悬浮液，以及溶解在其中的足以将 pH 值稳定在所述值的缓冲组合物，所述缓冲组合物包括式中的有机碱的混合物 其中 R1 和 R2 各为氢或 CH2CH20H 及其酸加成盐的混合物，最好是三(羟甲基)氨基甲烷及其盐酸盐的混合物。此外，还公开了制备所述疫苗组合物的工艺。该疫苗组合物具有很高的效力，其 pH 值在长时间内保持稳定。
• Fluoreszenzpolarisationsimmunoassay und Reagentien dafür
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0392332A2

  公开（公告）日：1990-10-17

  Ein Reagens zur Verwendung beim Fluoreszenzpolarisa­tionsimmunoassay für 11-nor-Δ9-Tetrahydrocannabinol-9-car­bonsäure (ein wichtiger Metabolit des Rauschgiftes Marihuana) enthält neben einem Antikörper für diesen Meta­boliten und einem wässrigen Puffer ein Freisetzungsmittel. Dieses Freisetzungsmittel bindet an und blockiert unspezi­fische Bindungsstellen des im Urin vorhandenen Humanserum­albumins und von anderen Proteinen im Urin und ermöglicht dadurch eine zuverlässigere Erfassung des so "freigesetzten" Metaboliten. Auch werden Varianten eines unter Verwendung der Freisetzungsmittel durchgeführten Verfahrens zur Erfassung des Metaboliten beschrieben.

  用于 11-去甲-Δ9-四氢大麻酚-9-羧酸（大麻的一种重要代谢物）荧光偏振免疫测定的试剂含有这种代谢物的抗体、水缓冲剂和释放剂。这种释放剂与尿液中的人血清白蛋白和其他蛋白质的非特异性结合点结合并阻断这些结合点，从而能更可靠地检测出以这种方式 "释放 "出来的代谢物。此外，还介绍了使用释放剂检测代谢物的各种方法。
• Waterbased acrylic silane and polyurethane containing coating composition
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0601219A1

  公开（公告）日：1994-06-15

  A waterbased coating composition containing about 10-30% by weight of film forming binder dispersed in an aqueous carrier; wherein the binder contains a. an acrylic silane polymer of polymerized monomers of alkyl methacrylate, alkyl acrylate or mixtures thereof, a silane containing alkyl acrylate or methacrylate and the polymer has an acid no. of 2-100 and a hydroxyl no. of up to 100, a glass transition temperature of -40 to 25C and a weight average molecular weight of 500,000 to 3,000,000; and b. a polyurethane selected from the following group: polyester urethane, polyether urethane or polyacrylourethane; the composition is useful for painting and refinishing the exterior of automobiles and trucks.

  一种水基涂料组合物，含有按重量计约 10-30%分散在水性载体中的成膜粘合剂；其中粘合剂含有 a. 一种丙烯酸硅烷聚合物，由甲基丙烯酸烷基酯、丙烯酸烷基酯或其混合物的聚合单体、含有丙烯酸烷基酯或甲基丙烯酸酯的硅烷组成，该聚合物的酸数为 2-100，羟基数最多为 100，玻璃化转变温度为-40-25℃，重量平均分子量为 500,000-3,000,000 ；以及 b. 选自以下组别的聚氨酯：聚酯聚氨酯、聚醚聚氨酯或聚丙烯酰基聚氨酯； 该组合物可用于汽车和卡车外部的喷漆和修补。
• Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof
  申请人：Novartis AG

  公开号：US10081697B2

  公开（公告）日：2018-09-25

  The invention provides a hydrophilized polydiorganosiloxane vinylic crosslinker which comprises (1) a polydiorganosiloxane polymer chain comprising dimethylsiloxane units and hydrophilized siloxane units each having one methyl substituent and one monovalent C4-C40 organic radical substituent having two to six hydroxyl groups, wherein the molar ratio of the hydrophilized siloxane units to the dimethylsiloxane units is from about 0.035 to about 0.15, and (2) two terminal (meth)acryloyl groups. The hydrophilized polydiorganosiloxane vinylic crosslinker has a number average molecular weight of from about 3000 Daltons to about 80,000 Daltons. The present invention is also related to a silicone hydrogel contact lens, which comprises repeating units derived from a hydrophilized polydiorganosiloxane vinylic crosslinker of the invention.

  本发明提供了一种亲水聚二有机硅氧烷乙烯基交联剂，它包括(1)聚二有机硅氧烷聚合物链，该链由二甲基硅氧烷单元和亲水硅氧烷单元组成，每个二甲基硅氧烷单元具有一个甲基取代基和一个具有二至六个羟基的单价C4-C40有机基取代基，其中亲水硅氧烷单元与二甲基硅氧烷单元的摩尔比为约0.035至约0.15，以及(2)两个末端(甲基)丙烯酰基。亲水性聚二有机硅氧烷乙烯基交联剂的平均分子量为约 3000 道尔顿至约 80000 道尔顿。本发明还涉及一种硅酮水凝胶隐形眼镜，它包括由本发明的亲水聚二有机硅氧烷乙烯基交联剂衍生的重复单元。
• Silicone hydrogel contact lenses
  申请人：Alcon Inc.

  公开号：US10875967B2

  公开（公告）日：2020-12-29

  The present invention generally relates to inherently wettable silicone hydrogel contact lenses having relatively high oxygen permeability, relatively high equilibrium water content and relatively low elastic modulus. The present invention is also related to a method for making such inherently wettable silicone hydrogel contact lenses.

  本发明一般涉及具有相对较高透氧率、相对较高平衡水含量和相对较低弹性模量的固有可湿性硅水凝胶隐形眼镜。本发明还涉及制作这种固有可湿性硅水凝胶隐形眼镜的方法。