2-(3-氟苯基)哌啶 | 383128-42-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 中文名称: 2-(3-氟苯基)哌啶
• 英文名称: (rac)-2-(3-fluorophenyl)piperidine
• 英文别名: 2-(3-fluorophenyl)piperidine
• CAS: 383128-42-5
• 化学式: C₁₁H₁₄FN
• 分子量: 179.237
• InChiKey: YTYUBQPJRNWHGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P264,P280,P305+P351+P338,P337+P313
• 危险性描述：
  H319

反应信息

• 作为反应物：
  描述：

  2-(3-氟苯基)哌啶 在 titanium(IV) isopropylate 、 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 66.0h， 生成 methyl 7-(5-chloro-2-(2-(6'-(2-(3-fluorophenyl)piperidin-1-yl)-2'-methyl-4'-oxo-6',7'-dihydro-4'H-spiro[cyclopropan-1,8'-quinazolin]-3'(5'H)-yl)ethoxy)phenyl)-5-methylthieno[3,2-b]pyridin-3-carboxylate
  参考文献：
  名称：

  COMPOUNDS AND COMPOSITIONS AS eIF4E INHIBITORS AND USES THEREOF

  摘要：

  Described herein are compounds of Formula I, and their pharmaceutically acceptable salts, solvates, stereoisomers, or prodrugs, as well as their uses (e.g, as eIF4E inhibitors).

  公开号：

  WO2024103069A1
• 作为产物：
  描述：

  6-(3-fluorophenyl)-3,4-dihydropyridine-1(2H)-carbaldehyde 在 盐酸 、 palladium 10% on activated carbon 、 氢气 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 64.0h， 生成 2-(3-氟苯基)哌啶
  参考文献：
  名称：

  Discovery, synthesis and exploration of N-benzylsulfonyl-2-phenylazepanes as inhibitors of Bim expression in a mouse embryonic fibroblast model

  摘要：

  DOI：

  10.1016/j.bioorg.2022.105635

文献信息

• COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS
  申请人：Fan Yi

  公开号：US20120065184A1

  公开（公告）日：2012-03-15

  The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity.

  该发明提供了化合物、包含该化合物的药物组合物以及使用该化合物治疗或预防与TRK激酶活性异常或失调相关的疾病或病症的方法。
• SULTAM DERIVATIVES
  申请人：Anderson Kevin W.

  公开号：US20110124686A1

  公开（公告）日：2011-05-26

  The present invention relates to compounds according to formula 1, which exhibit cytotoxic activity. The compounds may be used in the treatment of cancer.

  本发明涉及符合式1的化合物，具有细胞毒活性。这些化合物可用于治疗癌症。
• [EN] BENZOXAZEPINES AS INHIBITORS OF PI3K/m TOR AND METHODS OF THEIR USE AND MANUFACTURE<br/>[FR] BENZOXAZÉPINES COMME INHIBITEURS DE PI3K/M TOR, MÉTHODES D'UTILISATION ET DE FABRICATION BENZOXAZEPINES AS INHIBITORS OF PI3K/M TOR AND METHODS OF THEIR USE AND MANUFACTURE
  申请人：EXELIXIS INC

  公开号：WO2010138487A1

  公开（公告）日：2010-12-02

  The invention is directed to Compounds of Formula (I): the invention provides compounds that inhibit, regulate, and/or modulate P13K and/or mTOR that are useful in the treatment of hyperproliferative diseases, such as cancer, in mammals. This invention also provides methods of making the compound methods of using such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds. For example, cancer in which activity against PI3fC-alph mTOR, or both contributes to its pathology and/or symptomatology include breast cancer mantle cell lymphoma, renal cell carcinoma, acute myelogenous leukemia, chronic myelogenous leukemia, NPM/ALK- transformed anaplastic large cell lymphoma, diffu large B cell lymphoma, rhabdomyosarcoma, ovarian cancer, endometrial cancer, cervic cancer, non small cell lung carcinoma, small cell lung carcinoma, adenocarcinoma, col cancer, rectal cancer, gastric carcinoma, hepatocellular carcinoma, melanoma, pancreat cancer, prostate carcinoma, thyroid carcinoma, anaplastic large cell lymphoma, hemangiom glioblastoma, or head and neck cancer.

  这项发明涉及式(I)的化合物：该发明提供了抑制、调节和/或调节P13K和/或mTOR的化合物，这些化合物在治疗哺乳动物的高增殖性疾病，如癌症，方面非常有用。该发明还提供了制备该化合物的方法，以及在治疗哺乳动物，特别是人类的高增殖性疾病中使用这些化合物的方法，以及含有这些化合物的药物组合物。例如，对PI3fC-α mTOR或两者都具有活性有助于其病理学和/或症状学的癌症包括乳腺癌、套细胞淋巴瘤、肾细胞癌、急性髓细胞白血病、慢性髓细胞白血病、NPM/ALK转化的间变性大细胞淋巴瘤、弥漫性大B细胞淋巴瘤、横纹肌肉瘤、卵巢癌、子宫内膜癌、宫颈癌、非小细胞肺癌、小细胞肺癌、腺癌、结肠癌、直肠癌、胃癌、肝细胞癌、黑色素瘤、胰腺癌、前列腺癌、甲状腺癌、间变性大细胞淋巴瘤、血管瘤、胶质母细胞瘤或头颈癌。
• [EN] SUBSTITUTED IMIDAZO[1,2B]PYRIDAZINE COMPOUNDS AS TRK KINASE INHIBITORS<br/>[FR] COMPOSÉS IMIDAZO[1,2B]PYRIDAZINE SUBSTITUÉS COMME INHIBITEURS DE KINASES TRK
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2010033941A1

  公开（公告）日：2010-03-25

  Compounds of Formula (I): in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor.

  式（I）化合物：其中R1、R2、R3、R4、X、Y和n的含义如规范中所述，是Trk激酶的抑制剂，并且在治疗可以使用Trk激酶抑制剂治疗的疾病中是有用的。
• SUBSTITUTED IMIDAZO[1,2b]PYRIDAZINE COMPOUNDS AS TRK KINASE INHIBITORS
  申请人：Andrews Steven W.

  公开号：US20110166122A1

  公开（公告）日：2011-07-07

  Compounds of Formula (I): in which R 1 , R 2 , R 3 , R 4 , X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor.

  式(I)的化合物：其中R1、R2、R3、R4、X、Y和n具有规范中给出的含义，是Trk激酶的抑制剂，可用于治疗可用Trk激酶抑制剂治疗的疾病。