N,N,N',N'-Tetraisopropyl-m-phenylenediamine | 27594-20-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N,N',N'-Tetraisopropyl-m-phenylenediamine
• 英文别名: 1,3-bis(diisopropylamino)benzene；1,3-Diisopropylamino-benzol；N~1~,N~1~,N~3~,N~3~-Tetra(propan-2-yl)benzene-1,3-diamine；1-N,1-N,3-N,3-N-tetra(propan-2-yl)benzene-1,3-diamine
• CAS: 27594-20-3
• 化学式: C₁₈H₃₂N₂
• 分子量: 276.465
• InChiKey: AJHZVHVQJHGJJJ-UHFFFAOYSA-N

物化性质

• 沸点：
  377.7±25.0 °C(Predicted)
• 密度：
  0.924±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三氟甲磺酸-2-氯苯醚 、 二异丙胺 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 1.17h， 生成 N,N,N',N'-Tetraisopropyl-m-phenylenediamine 、 N,N-Diisopropyl-3-chloroaniline
  参考文献：
  名称：

  芳基三氟甲磺酸酯的阴离子硫杂-弗里斯重排。

  摘要：

  芳基三氟甲磺酸酯经历LDA介导的重排，生成邻羟基芳基三氟甲基砜。在某些情况下，可以控制重排和芳烃生成之间的分配。

  DOI：

  10.1039/b210648e

文献信息

• Eight-arm polyethylene glycol derivative, production method therefor, and modified bio-related substance thereof
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US10434182B2

  公开（公告）日：2019-10-08

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups Ec form a highly symmetrical octavalent group CORE0; Lc connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n1 to n8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.

  本发明公开了一种八臂聚乙二醇（PEG）衍生物（式 I）、其生产方法及其改性生物相关物质。其中，一个四价基团 U 与四个三价基团 Ec 形成一个高度对称的八价基团 CORE0；Lc 将八价基团连接到八条具有多分散性或单分散性且聚合度为 n1 至 n8 的 PEG 链上；一条 PEG 链的末端与至少一个官能团 F 连接（k≥1）；所述 PEG 链和 F 之间可以直接连接（g=0），也可以通过连接基团 L0 与末端支化基团 G 间接连接（g=1）；后者提供了更多的反应位点，可以结合更多的药物分子，增加药物负载量。八臂聚乙二醇衍生物具有中心对称或近似中心对称结构，因此在大规模生产中可以更精确地控制分子量，产品的分子量分布也更窄。因此，改性生物相关物质的性能更均匀、更可控。
• Regiospecific Metalation of Oligobromobenzenes
  作者：Sergiusz Luliński、Janusz Serwatowski

  DOI：10.1021/jo0340511

  日期：2003.6.1

  The metalation of selected oligobromobenzenes with lithium diisopropylamide (LDA) was investigated. 1,3-Dibromo-substituted benzenes were metalated without special precautions since the resultant 2,6-dibromophenyllithium intermediates are relatively stable under reaction conditions: corresponding benzaldehydes were obtained in good or moderate yields after subsequent quench with N,N-dimethylformamide (DMF). Aryllithium compounds derived from 1,4- and 1,2-dibromobenzene are much less stable, but they could be trapped by the in situ use of chlorotrimethylsilane. The one-pot metalation/disilylation of 1,4-dibromo- and 1,2-dibromobenzene afforded 1,4-dibromo-2,5-bis(trimethylsilyl)benzene and 2,3-dibromo-1,4-bis(trimethylsilyl)benzene, respectively.
• Competition studies on aryne generation from halophenyl triflates
  作者：Peter P. Wickham、Kelly Hardee Reuter、Dilojan Senanayake、Hong Guo、Mark Zalesky、William J. Scott

  DOI：10.1016/s0040-4039(00)60389-1

  日期：1993.11

  Reaction of halophenyl triflates with LDA in diisopropylamine at -78-degrees-C affords isomeric mixtures of halo-N,N-diisopropylanilines, occasionally accompanied by variable amounts of m-bis(N,N-diisopropylamino)benzene and/or small amounts of N,N-diisopropylaniline. Use of ortho- or meta-halophenyl triflates gives largely the m-haloaniline, while the p-haloaniline predominates in reactions of the para- isomer. The magnitude of the directing effects varies with the halide (Cl>Br>I).
• EIGHT-ARM POLYETHYLENE GLYCOL DERIVATIVE, PRODUCTION METHOD THEREFOR, AND MODIFIEDBIO-RELATEDSUBSTANCETHEREOF
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD

  公开号：US20180214561A1

  公开（公告）日：2018-08-02

  Disclosed are an eight-arm polyethylene glycol (PEG) derivative (formula I), production method therefor and modified bio-related substance thereby. Wherein, one tetravalent group U together with four trivalent groups E c form a highly symmetrical octavalent group CORE 0 ; L c connects the octavalent group to eight PEG chains having polydispersity or monodispersity and having n 1 to n 8 as the degree of polymerization thereof; the terminal of one PEG chain is connected to at least one functional group F (k≥1); said PEG chain and F therebetween can be directly connected (g=0) or be indirectly connected via a linking group L 0 to a terminal end-branching group G (g=1); the latter provides more reactive sites for binding more drug molecules and increases the drug loading. The eight-arm polyethylene glycol derivative has a centrosymmetric or approximately centrosymmetric structure, and leads to more precise control of the molecular weight in large-scale production and much narrower distribution of molecular weight for products. The modified bio-related substance thereby has a more uniform and controllable performance.
• US4189171A
  申请人：——

  公开号：US4189171A

  公开（公告）日：1980-02-19