5-chloro-1,2-dihydrofuro<3,2-f><1,7>naphthyridine | 173540-66-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 5-chloro-1,2-dihydrofuro<3,2-f><1,7>naphthyridine
• 英文别名: 5-Chloro-1,2-dihydrofuro[3,2-f][1,7]naphthyridine
• CAS: 173540-66-4
• 化学式: C₁₀H₇ClN₂O
• 分子量: 206.631
• InChiKey: GRIKXIOXSXQDSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5-chloro-1,2-dihydrofuro<3,2-f><1,7>naphthyridine 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以78%的产率得到5-hydrazino-1,2-dihydrofuro<3,2-f><1,7>naphthyridine
  参考文献：
  名称：

  Polycyclic N-Heterocyclic Compounds. 49 New Synthetic Method of Furo[3,2-f][1,7]naphthyridine Skeleton

  摘要：

  An synthesis of 5-amino-1,2-dihydrofuro[3,2-f][1,7]naphthyridine (6) from 3-(3-cyanopropoxy)pyridine-2-carbonitrile (5) is described. Compound (6) was converted to mother skeleton (12). Treatment of 6 with conc. hydrochloric acid gave new spiroheterocycle (7).

  DOI：

  10.3987/com-95-7212
• 作为产物：
  描述：

  5-amino-1,2-dihydrofuro<3,2-f><1,7>naphthyridine 在 盐酸 、 碳酸氢钠 、 sodium nitrite 作用下， 以 水 为溶剂， 以67%的产率得到5-chloro-1,2-dihydrofuro<3,2-f><1,7>naphthyridine
  参考文献：
  名称：

  Polycyclic N-Heterocyclic Compounds. 49 New Synthetic Method of Furo[3,2-f][1,7]naphthyridine Skeleton

  摘要：

  An synthesis of 5-amino-1,2-dihydrofuro[3,2-f][1,7]naphthyridine (6) from 3-(3-cyanopropoxy)pyridine-2-carbonitrile (5) is described. Compound (6) was converted to mother skeleton (12). Treatment of 6 with conc. hydrochloric acid gave new spiroheterocycle (7).

  DOI：

  10.3987/com-95-7212

文献信息

• Polycyclic<i>N</i>-Heterocyclic Compounds, Part 71: Synthesis and Bronchodilator Evaluation of 5-Substituted 1,2-Dihydrofuro[3,2-<i>f</i>][1,7]naphthyridines and Related Compounds
  作者：Kensuke Okuda、Tetsuo Matsushita、Takashi Hirota、Kenji Sasaki

  DOI：10.1002/jhet.846

  日期：2012.7

  Several 5‐substituted 1,2‐dihydrofuro[3,2‐f][1,7]naphthyridines were synthesized as part of our research to develop new effective bronchodilators. Amines, sulfanyls, and alcohols were used as substituents at the fifth position. Tetracyclic compounds were also obtained. Evaluation of the effects of the newly synthesized compounds on carbamoylcholine chloride‐induced contractions of trachea revealed

  几种5-取代的1,2-二氢呋喃[3,2- f ] [1,7]萘啶被合成为我们开发新的有效支气管扩张剂的研究的一部分。胺，硫烷基和醇用作第五位的取代基。还获得了四环化合物。对新合成的化合物对氨甲酰胆碱氯化物引起的气管收缩的影响进行评估后，发现了一种有希望的支气管扩张剂，其功效与3-异丁基-1-甲基黄嘌呤相当。
• Polycyclic N-Heterocyclic Compounds. 49 New Synthetic Method of Furo[3,2-f][1,7]naphthyridine Skeleton
  作者：Takashi Hirota、Tetsuo Matsushita、Kenji Sasaki、Setsuo Kashino

  DOI：10.3987/com-95-7212

  日期：——

  An synthesis of 5-amino-1,2-dihydrofuro[3,2-f][1,7]naphthyridine (6) from 3-(3-cyanopropoxy)pyridine-2-carbonitrile (5) is described. Compound (6) was converted to mother skeleton (12). Treatment of 6 with conc. hydrochloric acid gave new spiroheterocycle (7).