2-acetyl-3-anilino-N-cyclohexylindolizine-1-carboxamide | 1340587-94-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 2-acetyl-3-anilino-N-cyclohexylindolizine-1-carboxamide
• CAS: 1340587-94-1
• 化学式: C₂₃H₂₅N₃O₂
• 分子量: 375.47
• InChiKey: NZEOJJHHGRUKGT-UHFFFAOYSA-N

物化性质

• 密度：
  1.24±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  62.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吡啶-2-甲醛 、 异氰环已烷 、 N-乙酰乙酰苯胺 以 甲苯 为溶剂， 以94%的产率得到2-acetyl-3-anilino-N-cyclohexylindolizine-1-carboxamide
  参考文献：
  名称：

  A novel one-pot domino reaction for the synthesis of 2-acetyl-3-(phenylamino)indolizine-1-carboxamide derivatives

  摘要：

  2-Acetyl-3-(phenylamino)indolizine-l-carboxamide derivatives were obtained via a one-pot domino reaction of alkyl or aryl isocyanides and pyridine-2-carbaldehyde in the presence of acetoacetanilide in toluene without any prior activation or modification. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.08.118

文献信息

• A novel one-pot domino reaction for the synthesis of 2-acetyl-3-(phenylamino)indolizine-1-carboxamide derivatives
  作者：Morteza Ziyaadini、Nourallah Hazeri、Malek Taher Maghsoodlou、Sayyed Mostafa Habibi-Khorassani、Anthony C. Willis

  DOI：10.1016/j.tetlet.2011.08.118

  日期：2011.11

  2-Acetyl-3-(phenylamino)indolizine-l-carboxamide derivatives were obtained via a one-pot domino reaction of alkyl or aryl isocyanides and pyridine-2-carbaldehyde in the presence of acetoacetanilide in toluene without any prior activation or modification. (C) 2011 Elsevier Ltd. All rights reserved.