2-(2-chlorophenyl)-1-(4-chlorophenyl)ethanone | 92152-98-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-(2-chlorophenyl)-1-(4-chlorophenyl)ethanone
• 英文别名: 4'-Chlor-2-(2-chlorphenyl)-acetophenon；4,2'-dichloro-deoxybenzoin；4,2'-Dichlor-desoxybenzoin；(2-chlorobenzyl)(4-chlorophenyl)methanone；4'-chloro-2-(o-chlorophenyl)acetophenone；2-chlorobenzyl 4-chlorophenyl ketone
• CAS: 92152-98-2
• 化学式: C₁₄H₁₀Cl₂O
• mdl: MFCD00759401
• 分子量: 265.139
• InChiKey: VMEPFMQBGKXQKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(2-chlorophenyl)-1-(4-chlorophenyl)ethanone 在 lithium aluminium tetrahydride 作用下， 生成 1-氯-2-[(E)-2-(4-氯苯基)乙烯基]苯
  参考文献：
  名称：

  1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane and Related Compounds¹

  摘要：

  DOI：

  10.1021/jo01059a110
• 作为产物：
  描述：

  对氯苯甲腈 在 碘 magnesium 、 盐酸 、 水 作用下， 以 乙醚 、 四氢呋喃 为溶剂， 反应 6.0h， 以74%的产率得到2-(2-chlorophenyl)-1-(4-chlorophenyl)ethanone
  参考文献：
  名称：

  WO2008/4698

  摘要：

  公开号：

文献信息

• New Preparation of Benzylic Manganese Chlorides by the Direct Insertion of Magnesium into Benzylic Chlorides in the Presence of MnCl2·2LiCl
  作者：Paul Knochel、Pauline Quinio、Andreas Benischke、Alban Moyeux、Gérard Cahiez

  DOI：10.1055/s-0034-1379944

  日期：——

  Functionalized benzylic manganese chlorides were smoothly prepared by the direct insertion of magnesium into benzylic chlorides in the presence of MnCl2·2LiCl. Reactions with acid chlorides, aldehydes, an allyl bromide, and an enone proceed without any additional transition metal.

  在MnCl2·2LiCl存在下，通过将镁直接插入苄基氯化物中，顺利地制备了官能化苄基氯化锰。与酰氯、醛、烯丙基溴和烯酮的反应无需任何额外的过渡金属即可进行。
• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：ASTRAZENECA AB

  公开号：WO2004011410A1

  公开（公告）日：2004-02-05

  Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.

  式(I)的化合物：其中变量基团如定义内；用于抑制11βHSD1。
• Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines
  作者：R. Ramajayam、Rajani Giridhar、M.R. Yadav、R. Balaraman、Hakim Djaballah、David Shum、Constantin Radu

  DOI：10.1016/j.ejmech.2007.11.023

  日期：2008.9

  The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet

  描述了2,3-二芳基-6,7-二氢-5H-1,4-二氮杂卓的合成，抗白血病和抗血小板活性的评价。通常，发现化合物17o显示出对MOLT3人白血病癌细胞系的中等抗白血病活性。研究了花生四烯酸对洗涤过的大鼠血小板的血小板聚集作用。发现化合物17i是最有效的。抗血小板特性可以通过干扰花生四烯酸途径来介导。
• Ketones
  申请人：Barton John Peter

  公开号：US20050272036A1

  公开（公告）日：2005-12-08

  Compounds of formula (I): wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.

  描述了式(I)的化合物：其中变量基团如定义的那样；用于抑制11βHSD1。
• PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AS CB1 RECEPTOR ANTAGONIST
  申请人：Tanimoto Koichi

  公开号：US20090258867A1

  公开（公告）日：2009-10-15

  The present invention provides a pyrazolo[1,5-a]pyrimidine compound, having CB1 receptor-antagonizing activity, of the following formula [I]: in which R 1 and R 2 are the same or different and each an optionally substituted aryl group etc, R 0 is hydrogen atom, an alkyl group etc, E is a group of the formula: —C(═O)— or —SO 2 —, R is a group of the following formula [i], [ii] or [iii] etc: Ring A is (a) a C 3-8 cycloalkyl group optionally fused to a benzene ring or (b) a benzene ring, Q is a single bond or a methylene group, Ring B is a 4- to 7-membered aliphatic heterocyclic group, said cyclic group binding via its ring-carbon atom to the adjacent nitrogen atom, X is sulfur atom etc, R 3 is an alkyl group optionally substituted by an alkylthio group, R 4 is hydrogen atom, an alkyl group etc, one of R A and R B is an alkyl group etc, and the other is hydrogen atom, an alkyl group etc, or a pharmaceutically acceptable salt thereof.

  本发明提供了一种具有CB1受体拮抗活性的吡唑并[1,5-a]嘧啶化合物，其化学式[I]如下：其中，R1和R2相同或不同，分别是可选取代的芳基等；R0是氢原子，烷基等；E是以下式子的基团：—C(═O)—或—SO2—；R是以下式子[i]、[ii]或[iii]等的基团：环A是(a)一个C3-8环烷基，可选地融合到苯环上，或(b)一个苯环；Q是单键或亚甲基基团；环B是一个4-7个成员的脂肪族杂环基团，该环基团通过其环碳原子与相邻的氮原子结合；X是硫原子等；R3是可选取代的烷基，可以是烷基硫基等；R4是氢原子，烷基等；RA和RB中的一个是烷基等，另一个是氢原子，烷基等，或其药学上可接受的盐。