5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid | 849727-81-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: 5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid
• 英文别名: 5-[3-[4-[2-(4-fluorophenyl)ethoxy]phenyl]propyl]furan-2-carboxylic acid
• CAS: 849727-81-7
• 化学式: C₂₂H₂₁FO₄
• 分子量: 368.4
• InChiKey: MPLLLQUZNJSVTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] THIADIAZOLONE DERIVATIVES USEFUL IN THE TREATMENT OF DIABETES<br/>[FR] DÉRIVÉS DE THIADIAZOLONE UTILES DANS LE TRAITEMENT DU DIABÈTE
  申请人：BALTIC BIO AB

  公开号：WO2013108026A1

  公开（公告）日：2013-07-25

  According to the invention there is provided a compound of formula I, wherein, R1 to R4 have meanings given in the description, which compounds are useful in the treatment of diabetes.

  根据本发明提供了一种I式化合物，其中R1到R4的含义如描述中所给，这些化合物在糖尿病治疗中有用。
• [EN] COMPOUNDS USEFUL AS INHIBITORS AS AMPK<br/>[FR] COMPOSÉS UTILES EN TANT QU'INHIBITEURS TEL QUE AMPK
  申请人：BETAGENON AB

  公开号：WO2010086613A1

  公开（公告）日：2010-08-05

  According to the invention there is provided a compound of formula (I), wherein, X, T, Y1 E, M, A1 to A5 and D1 to D5 have meanings given in the description, which compounds are useful in the treatment of cancer.

  根据本发明，提供了一种式子为(I)的化合物，其中，X、T、Y1、E、M、A1至A5和D1至D5的含义如说明书所述，这些化合物可用于癌症的治疗。
• 1,2,4-THIAZOLOIDIN-3-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER
  申请人：Westman Jacob

  公开号：US20120183537A1

  公开（公告）日：2012-07-19

  According to the invention there is provided a compound of formula (I) wherein: A represents C(═N—W-D) or S; B represents S or C(—NH—W-D); when: A represents C(═N—W-D) and B represents S then the bond between B and the NH atom is a single bond; or A represents S and B represents C(—NH—W-D) then the bond between B and the NH atom is a double bond; X represents -Q-[CR x R y ] n —; W represents —[CR x R y ] m — or —C(O)—[CR x R y ] p —; Q represents a bond, —N(R a )—, —S—, or —O—; A 1 to A 5 respectively represent C(R 1 ), C(R 2 ), C(R 3 ), C(R 4 ) and C(R 5 ), or, alternatively, up to two of A 1 to A 5 may independently represent N; D represents phenyl, pyridyl or pyrimidinyl optionally substituted by one or more R 6 groups, which compounds are useful in the treatment of cancer.

  根据发明提供了一种化合物，其化学式为(I)，其中：A代表C(═N—W-D)或S；B代表S或C(—NH—W-D)；当：A代表C(═N—W-D)且B代表S时，B和NH原子之间的键为单键；或者A代表S且B代表C(—NH—W-D)时，B和NH原子之间的键为双键；X代表-Q-[CRxRy]n—；W代表—[CRxRy]m—或—C(O)—[CRxRy]p—；Q代表键，—N(Ra)—，—S—或—O—；A1至A5分别代表C(R1)、C(R2)、C(R3)、C(R4)和C(R5)，或者，最多两个A1至A5可以独立地代表N；D代表苯基、吡啶基或嘧啶基，可选择地被一个或多个R6基团取代，这些化合物在癌症治疗中有用。
• 1,2,4-THIAZOLIDIN-3-ONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER
  申请人：Baltic Bio AB

  公开号：US20160128993A1

  公开（公告）日：2016-05-12

  According to the invention there is provided a compound of formula (I) wherein: A represents C(═N—W-D) or S; B represents S or C(—NH—W-D); when: A represents C(═N—W-D) and B represents S then the bond between B and the NH atom is a single bond; or A represents S and B represents C(—NH—W-D) then the bond between B and the NH atom is a double bond; X represents -Q-[CR x R y ] n —; W represents —[CR x R y ] m — or —C(O)—[CR x R y ] p —; Q represents a bond, —N(R a )—; —S—, or —O—; A 1 to A 5 respectively represent C(R 1 ), C(R 2 ), C(R 3 ), C(R 4 ) and C(R 5 ), or, alternatively, up to two of A 1 to A 5 may independently represent N; D represents phenyl, pyridyl or pyrimidinyl optionally substituted by one or more R 6 groups, which compounds are useful in the treatment of cancer.

  根据本发明提供一种化合物，其化学式为(I)，其中：A代表C(═N—W-D)或S；B代表S或C(—NH—W-D)；当：A代表C(═N—W-D)且B代表S时，B与NH原子之间的键为单键；或A代表S且B代表C(—NH—W-D)时，B与NH原子之间的键为双键；X代表-Q-[CRxRy]n—；W代表—[CRxRy]m—或—C(O)—[CRxRy]p—；Q代表键，—N(Ra)—；—S—；或—O—；A1到A5分别代表C(R1)、C(R2)、C(R3)、C(R4)和C(R5)，或者，最多两个A1到A5可以独立地代表N；D代表苯基、吡啶基或嘧啶基，可以选择地被一个或多个R6基团取代，这些化合物在癌症治疗中有用。
• Treating ocular neovascularization
  申请人：Massachusetts Eye & Ear Infirmary

  公开号：US10143703B2

  公开（公告）日：2018-12-04

  Methods of treating ocular neovascularization, e.g., associated with wet agerelated macular degeneration (AMD), using activators of AMP-activated protein kinase (AMPK) and/or of Phosphatase and tensin homolog deleted on chromosome 10 (PTEN).

  使用 AMP 激活蛋白激酶 (AMPK) 和/或 10 号染色体上删除的磷酸酶和天丝同源物 (PTEN) 的激活剂治疗眼部新生血管，例如与湿性老年性黄斑变性 (AMD) 相关的新生血管的方法。