3-(naphthalen-2-yl)-2-methoxycarbonylbenzo[b]thiophene | 1415703-24-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-(naphthalen-2-yl)-2-methoxycarbonylbenzo[b]thiophene
• 英文别名: Methyl 3-naphthalen-2-yl-1-benzothiophene-2-carboxylate；methyl 3-naphthalen-2-yl-1-benzothiophene-2-carboxylate
• CAS: 1415703-24-0
• 化学式: C₂₀H₁₄O₂S
• 分子量: 318.396
• InChiKey: STSLTNNTXPYVNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-硝基苯甲腈 在 potassium phosphate 、 四(三苯基膦)钯 、 亚硝酸特丁酯 、 potassium hydroxide 、 copper(ll) bromide 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 7.0h， 生成 3-(naphthalen-2-yl)-2-methoxycarbonylbenzo[b]thiophene
  参考文献：
  名称：

  Design and synthesis of condensed thienocoumarins by Suzuki–Miyaura reaction/lactonization tandem protocol

  摘要：

  A concise and efficient approach to a series of chromen-4-ones with fused thiophene ring has been developed using the Suzuki-Miyaura reaction of bromothiophene-2- and 3-carboxylates with 2-methoxyboronic acids and subsequent cyclization of prepared alkyl (2-methoxy)aryl thiophene-2- and 3-carboxylates under the action of BBr3/KOtBu. Starting bromothiophenes are easily obtained from corresponding commercially available aminothiophenes by diazotization/bromination reaction. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.096

文献信息

• Design and synthesis of condensed thienocoumarins by Suzuki–Miyaura reaction/lactonization tandem protocol
  作者：Viktor O. Iaroshenko、Sajid Ali、Satenik Mkrtchyan、Ashot Gevorgyan、Tariq Mahmood Babar、Volodymyr Semeniuchenko、Zahid Hassan、Alexander Villinger、Peter Langer

  DOI：10.1016/j.tetlet.2012.10.096

  日期：2012.12

  A concise and efficient approach to a series of chromen-4-ones with fused thiophene ring has been developed using the Suzuki-Miyaura reaction of bromothiophene-2- and 3-carboxylates with 2-methoxyboronic acids and subsequent cyclization of prepared alkyl (2-methoxy)aryl thiophene-2- and 3-carboxylates under the action of BBr3/KOtBu. Starting bromothiophenes are easily obtained from corresponding commercially available aminothiophenes by diazotization/bromination reaction. (C) 2012 Elsevier Ltd. All rights reserved.