2-(4-溴苯基)-1-(2,4-二氯苯基)乙酮 | 605670-75-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 2-(4-溴苯基)-1-(2,4-二氯苯基)乙酮
• 英文名称: 2-(4-Bromophenyl)-1-(2,4-dichlorophenyl)ethanone
• CAS: 605670-75-5
• 化学式: C₁₄H₉BrCl₂O
• mdl: MFCD19101867
• 分子量: 344.035
• InChiKey: UAKMYTXDYUZDNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-溴苯基)-1-(2,4-二氯苯基)乙酮 在 三氯氧磷 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 48.0h， 生成 2-(4-bromophenyl)-3-chloro-3-(2,4-dichloro-phenyl)acrylaldehyde
  参考文献：
  名称：

  N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION

  摘要：

  本发明涉及式（I）的化合物：其中X，R1，R2，R3和R4如本文所述。本发明还涉及制备上述化合物的方法及其治疗应用。

  公开号：

  US20070287744A1
• 作为产物：
  描述：

  2,4-二氯苯甲酸甲酯 在 sodium hexamethyldisilazane 、 盐酸 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 2-(4-溴苯基)-1-(2,4-二氯苯基)乙酮
  参考文献：
  名称：

  N-[(4,5-DIPHENYL-2-THIENYL)METHYL]SULFONAMIDE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTIC APPLICATION

  摘要：

  本发明涉及式（I）的化合物：其中X，R1，R2，R3和R4如本文所述。本发明还涉及制备上述化合物的方法及其治疗应用。

  公开号：

  US20070287744A1

文献信息

• N-[(4,5-DIPHENYL-2-THIENYL)METHYL]AMINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
  申请人：DUCOUX Jean-Philippe

  公开号：US20080009543A1

  公开（公告）日：2008-01-10

  The subject of the present invention is compounds corresponding to formula (I): Wherein X, R 1 , R 2 , R 3 and R 4 are as described herein. The invention also relates to a method for the preparation and application of said compounds as cannabinoid CB1 receptor antagonists.

  本发明涉及与以下化学式（I）对应的化合物：其中X、R1、R2、R3和R4如本文所述。本发明还涉及一种用作大麻素CB1受体拮抗剂的化合物的制备和应用方法。
• N-[(4,5-DIPHENYL-3-ALKYL-2-THIENYL)METHYL]AMINE [AMIDE, SULFONAMIDE, CARBAMATE AND UREA) DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS
  申请人：BARTH Francis

  公开号：US20070270470A1

  公开（公告）日：2007-11-22

  The invention concerns compounds of formula (I), wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. The invention also concerns a method for preparing said compounds and their use as cannabinoid CB1 receptor antagonists.

  该发明涉及式（I）的化合物，其中X，R1，R2，R3，R4和R5如本文所定义。该发明还涉及一种制备所述化合物的方法以及它们作为大麻素CB1受体拮抗剂的用途。
• N-[(4,5-DIPHENYLPYRIMIDIN-2-YL)METHYL]AMINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR THERAPEUTIC USE
  申请人：BARTH Francis

  公开号：US20080176867A1

  公开（公告）日：2008-07-24

  The invention relates to compounds of formula (I): Wherein X, R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein. The invention also relates to a method for preparing the aforementioned compounds and to their therapeutic use.

  该发明涉及以下化合物的公式(I)：其中X，R1，R2，R3，R4和R5如本文所定义。该发明还涉及制备上述化合物的方法以及它们的治疗用途。
• Thiazole derivatives having cb1-antagonistic, agonistic or partial agonistic activity
  申请人：——

  公开号：US20040266841A1

  公开（公告）日：2004-12-30

  The present invention relates to a group of thiazoloe derivatives which are potent antagonist, agonists or partial agonist of the cannabinoid CB 1 -receptor. The compounds have the general formula (I) wherein R and R 1 -R 4 have the meanings given in the specification, 1

  本发明涉及一组噻唑衍生物，它们是大麻素CB1受体的有效拮抗剂、激动剂或部分激动剂。该化合物具有通式（I），其中R和R1-R4具有规范中所给出的含义。
• Thiazole derivatives having CB1-antagonistic, agonistic or partial agonistic activity
  申请人：Solvay Pharmaceuticals, Inc.

  公开号：US07342032B2

  公开（公告）日：2008-03-11

  Computer game systems respond to the spatial state of a pointing device. Changes in the spatial state of a hand held or mobile unit, or plurality of units drive a game scheme maintained in a computer. Position and attitude of the mobile device cause program branching functions which are bases upon a game rule set. In example, a game scheme executed on a computing apparatus may be incorporated into a mobile telephone having a GPS and electronic compass. Physical states relating to position and pointing attitude of the telephone as described in part by position or attitude parameters, drives computer programming code to takes actions which depend on measured position and attitude values thus making computer games for mobile users are made highly interactive. User gestures including simple pointing actions allow a user to express desires to a computer in an express and direct fashion. These games have many features which cannot be found in more traditional handheld computer games which do not take into consideration the spatial state of an object controlled by a player-user

  计算机游戏系统响应指针设备的空间状态。手持或移动单元或多个单元的空间状态的变化驱动计算机中维护的游戏方案。移动设备的位置和姿态引起程序分支功能，这些功能是基于游戏规则集的。例如，在计算设备上执行的游戏方案可以并入具有GPS和电子罗盘的移动电话中。与电话的位置和指向姿态相关的物理状态，如位置或姿态参数的描述，驱动计算机编程代码采取依赖于测量的位置和姿态值的行动，从而使移动用户的计算机游戏变得高度互动。用户手势，包括简单的指向动作，允许用户以明确和直接的方式向计算机表达愿望。这些游戏具有许多特点，在传统手持式计算机游戏中找不到，因为它们没有考虑到玩家用户控制的对象的空间状态。