5β,6β-epoxy-hemslecin A | 1424038-86-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 5β,6β-epoxy-hemslecin A
• 英文别名: 5Beta,6Beta-Epoxy-Hemslecin A；[(6R)-6-hydroxy-2-methyl-5-oxo-6-[(1R,2S,4S,5S,7R,9R,11S,12S,14R,15R,16R)-4,5,14-trihydroxy-1,6,6,12,16-pentamethyl-18-oxo-8-oxapentacyclo[9.7.0.02,7.07,9.012,16]octadecan-15-yl]heptan-2-yl] acetate
• CAS: 1424038-86-7
• 化学式: C₃₂H₅₀O₉
• 分子量: 578.744
• InChiKey: UDGZYWGMEOFTBD-WBRWCAQASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  41
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  154
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  丁酸酐 、 5β,6β-epoxy-hemslecin A 在 吡啶 、 4-二甲氨基吡啶 作用下， 以87%的产率得到2,3,16-tri-O-butyryl-5β,6β-epoxy-hemslecin A
  参考文献：
  名称：

  Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors

  摘要：

  A series of hemslecin A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities, namely, inhibiting the secretion of hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and HBV DNA replication on HepG 2.2.15 cells. Most of the derivatives showed enhanced anti-HBV activities, of which compounds A1-A7, B5, C and E exhibited significant activities inhibiting HBV DNA replication with IC50 values of 2.8-11.6 mu M, comparable to that of the positive control, tenofovir. Compounds A1-A3, A5, B5, and C displayed low cytotoxicities, which resulted in high SI values of 89.7, 55.6, 77.8, >83.4, >55.8, and >150.5, respectively. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.024
• 作为产物：
  描述：

  葫芦素 IIA 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到5β,6β-epoxy-hemslecin A
  参考文献：
  名称：

  Synthesis of hemslecin A derivatives: A new class of hepatitis B virus inhibitors

  摘要：

  A series of hemslecin A derivatives were synthesized and evaluated for their anti-hepatitis B virus (HBV) activities, namely, inhibiting the secretion of hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and HBV DNA replication on HepG 2.2.15 cells. Most of the derivatives showed enhanced anti-HBV activities, of which compounds A1-A7, B5, C and E exhibited significant activities inhibiting HBV DNA replication with IC50 values of 2.8-11.6 mu M, comparable to that of the positive control, tenofovir. Compounds A1-A3, A5, B5, and C displayed low cytotoxicities, which resulted in high SI values of 89.7, 55.6, 77.8, >83.4, >55.8, and >150.5, respectively. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.01.024