4-(2-pyridylazo)resorcinol | 113964-55-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(2-pyridylazo)resorcinol
• 英文别名: 4-(2-pyridylazo)-1,3-benzenediol；4-(2'-pyridylazo)resorcinol；4-(2-pyridylazo) resorcinol；4-(2-pyridylazo)-resorcinol；4-pyridin-2-ylazo-benzene-1,3-diol；4-[2]Pyridylazo-resorcin
• CAS: 113964-55-9
• 化学式: C₁₁H₉N₃O₂
• 分子量: 215.211
• InChiKey: RJNYNDHYSJRRDW-BUHFOSPRSA-N

物化性质

• 沸点：
  438.2±20.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.91
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  78.07
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  sodium 2-pyridyldiazotate 、 间苯二酚 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 110.0h， 以40.7%的产率得到4-(2-pyridylazo)resorcinol
  参考文献：
  名称：

  Wiejak, Stanislaw; Pasternak, Ewaryst E.; Tomasik, Piotr, Polish Journal of Chemistry, 1984, vol. 58, # 7-8-9, p. 895 - 897

  摘要：

  DOI：

文献信息

• METHOD TO PRODUCE HYPERPOLARISED CARBOXYLATES AND SULPHONATES
  申请人：Lerche Mathilde H.

  公开号：US20100233096A1

  公开（公告）日：2010-09-16

  The invention relates to a dynamic nuclear polarisation method for producing hyperpolarised carboxylates or sulphonates or mixtures thereof wherein the carboxylate or sulphonate used in the method of the invention comprises certain inorganic cations. The invention further relates to compositions for use in that method.

  本发明涉及一种动态核极化方法，用于生产超极化羧酸盐或磺酸盐或其混合物，其中所使用的羧酸盐或磺酸盐包含某些无机阳离子。本发明还涉及用于该方法的组合物。
• 2-Indolyl Imidazo [4,5-d] Phenanthroline Derivatives and Their Use in the Treatment for Cancer
  申请人：Huesca Mario

  公开号：US20100168417A1

  公开（公告）日：2010-07-01

  2-indolyl imidazo[4,5-d]phenanthroline compounds of Formula I that are capable of intracellular chelation of transition metals and of exerting antiproliferative effects in cancer cells, that are cytostatic and/or cytotoxic, are provided. Compounds of Formula I can also induce apoptosis in cancer cells and are thus capable of exerting a cytotoxic effect on cancer cells. The compounds of Formula I are also capable of selectively inhibiting the proliferation of one or more of prostate cancer cells, colon cancer cells, non-small lung cancer cells and leukemia cells. The compounds of Formula I are also capable of increasing the expression of the zinc-regulated tumour suppressor, KLF4 and thus are useful in inhibiting the proliferation of cancer cells in which KLF4 functions as a tumour-suppressor, including, but not limited to, bladder cancer, cancers of the gastrointestinal tract and various leukemias.

  提供了能够在细胞内与过渡金属螯合并对癌细胞产生抗增殖作用的Formula I的2-吲哚基咪唑并[4,5-d]菲啰啉化合物，这些化合物具有细胞静止和/或细胞毒作用。Formula I的化合物还可以诱导癌细胞凋亡，因此能够对癌细胞产生细胞毒作用。Formula I的化合物还能够选择性地抑制前列腺癌细胞、结肠癌细胞、非小细胞肺癌细胞和白血病细胞中的一个或多个的增殖。Formula I的化合物还能够增加锌调节的肿瘤抑制基因KLF4的表达，因此在抑制KLF4作为肿瘤抑制基因发挥作用的癌细胞的增殖方面具有用处，包括但不限于膀胱癌、胃肠道癌和各种白血病。
• Method of Dynamic Nuclear Polarisation DNP
  申请人：Thaning Mikkel

  公开号：US20080260649A1

  公开（公告）日：2008-10-23

  The invention relates to a method of dynamic nuclear polarisation (DNP) using a combination of a trityl radical and a paramagnetic metal ion as the polarising agent leading to enhanced levels of polarisation in the sample to be polarised and to compositions and polarising agents for use in the method.

  该发明涉及一种动态核极化（DNP）方法，使用三苯甲基自由基和顺磁性金属离子作为极化剂，以提高待极化样品中的极化水平，以及用于该方法的组合物和极化剂。
• Method to Produce Hyperpolarised Carboxylates
  申请人：Thaning Mikkel

  公开号：US20080292551A1

  公开（公告）日：2008-11-27

  The invention relates to a dynamic nuclear polarisation method for producing hyperpolarised carboxylates of organic amines and amino compounds and compositions for use in that method. The DNP agent preferably is a stable oxygen-based, sulphur-based or carbon-based trityl radical. Optionally a paramagnetic metal ion is present.

  这项发明涉及一种动态核极化方法，用于生产有机胺和氨基化合物的超极化羧酸盐，并且用于该方法的组合物。DNP剂最好是稳定的基于氧、硫或碳的三苯基自由基。可选地，存在一个顺磁金属离子。
• CROSS-LINKED STAR-SHAPED SELF-ASSEMBLED POLYGLUTAMATES AND ITS USE AS CARRIERS IN BIOMEDICAL APPLICATIONS
  申请人：Centro Investigacion Principe Felipe

  公开号：EP3127938A1

  公开（公告）日：2017-02-08

  The invention relates to 3-arms star-shaped polyglutamic derivatives which are able to self-assemble to form bioresponsive nanometric globular structures with controllable size and shape. These multivalent constructs also present the ability of disassemble under specific physiological conditions and of linking covalently to agent(s) such as a drug and/or imaging probes and/or targeting moiety so that they can be used as carries in biomedical applications.

  该发明涉及能够自组装形成具有可控大小和形状的生物响应纳米球状结构的3臂星形多聚谷氨酸衍生物。这些多价构造体还具有在特定生理条件下解离以及共价连接到药物和/或成像探针和/或靶向基团等试剂的能力，因此它们可以用作生物医学应用中的载体。

表征谱图