5-(4-(ethoxycarbonyl)piperidin-1-yl)-1-hydroxypentylphosphonic acid | 1300119-29-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-(4-(ethoxycarbonyl)piperidin-1-yl)-1-hydroxypentylphosphonic acid
• 英文别名: [5-(4-Ethoxycarbonylpiperidin-1-yl)-1-hydroxypentyl]phosphonic acid
• CAS: 1300119-29-2
• 化学式: C₁₃H₂₆NO₆P
• 分子量: 323.326
• InChiKey: SXHOBWVBLVPHRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.6
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  5-溴戊醛 在 三甲基氯硅烷 、 lithium perchlorate 、 三乙胺 、 三甲氧基磷 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 、 水 、 丙酮 、 甲苯 为溶剂， 生成 5-(4-(ethoxycarbonyl)piperidin-1-yl)-1-hydroxypentylphosphonic acid
  参考文献：
  名称：

  TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS

  摘要：

  本申请公开了一种处理水不溶性纳米颗粒的方法，特别是金属和金属化合物的纳米颗粒，这些纳米颗粒在诊断成像中（如磁共振和X射线成像）中发挥作用，使用具有亲水基团的α-羟基膦酸共轭物处理，使纳米颗粒具有足够的亲水性以在诊断成像中发挥作用。公开的改性亲水性纳米颗粒包括那些改性共轭物的亲水基团为乙烯氧化物基聚合物和共聚物以及带电离子的纳米颗粒，这些纳米颗粒由过渡金属氧化物组成，如超顺磁性氧化铁和氧化钽。公开了足够亲水的纳米颗粒，以形成稳定的水性胶体悬浊液。还公开了使用改性亲水性纳米颗粒作为对比剂进行诊断成像，如磁共振和X射线成像。

  公开号：

  US20110104072A1

文献信息

• Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents
  申请人：Bales Brian Christopher

  公开号：US09205155B2

  公开（公告）日：2015-12-08

  The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.

  本申请公开了一种处理水不溶性纳米颗粒的方法，特别是处理在诊断成像中有用的金属和金属化合物纳米颗粒，例如MR和X射线成像，使用具有亲水性基团的α-羟基膦酸共轭物将纳米颗粒进行修饰，使其具有足够的亲水性在诊断成像中发挥作用。其中修改的亲水性纳米颗粒包括以乙烯氧基聚合物和共聚物以及离子性分子为基础的修饰共轭物的亲水性基团和由过渡金属氧化物组成的纳米颗粒，例如超顺磁性铁氧体和钽氧化物。还公开了足够亲水性以形成稳定水溶胶悬浮液的纳米颗粒。同时还公开了使用修改后的亲水性纳米颗粒作为对比剂进行诊断成像，例如MR和X射线成像。
• US9205155B2
  申请人：——

  公开号：US9205155B2

  公开（公告）日：2015-12-08
• US9827335B2
  申请人：——

  公开号：US9827335B2

  公开（公告）日：2017-11-28
• [EN] TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS<br/>[FR] TRAITEMENT DE NANOPARTICULES INSOLUBLES DANS L'EAU À L'AIDE DE CONJUGUÉS HYDROPHILES D'ACIDE ALPHA-HYDROXYPHOSPHONIQUE, NANOPARTICULES AINSI MODIFIÉES ET LEUR UTILISATION EN TANT QU'AGENTS DE CONTRASTE
  申请人：GEN ELECTRIC

  公开号：WO2011051422A2

  公开（公告）日：2011-05-05

  The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha- hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.
• TREATING WATER INSOLUBLE NANOPARTICLES WITH HYDROPHILIC ALPHA-HYDROXYPHOSPHONIC ACID CONJUGATES, THE SO MODIFIED NANOPARTICLES AND THEIR USE AS CONTRAST AGENTS
  申请人：Bales Brian Christopher

  公开号：US20110104072A1

  公开（公告）日：2011-05-05

  The present application discloses treating water insoluble nanoparticles, particularly nanoparticles of metals and metal compounds which find utility in diagnostic imaging such as MR and X-ray imaging, with an alpha-hydroxyphosphonic acid conjugate with a hydrophilic moiety to render the nanoparticles sufficiently hydrophilic to find utility in diagnostic imaging. Among the modified hydrophilic nanoparticles disclosed are those in which the hydrophilic moieties of the modifying conjugate are ethylene oxide based polymers and copolymers and zwitterions and the nanoparticles are composed of transition metal oxides such as superparamagnetic iron oxide and tantalum oxide. Disclosed are nanoparticles which are sufficiently hydrophilic to form stable aqueous colloidal suspensions. Also disclosed is diagnostic imaging such as MR and X-ray using the modified hydrophilic nanoparticles as contrast agents.

  本申请公开了一种处理水不溶性纳米颗粒的方法，特别是金属和金属化合物的纳米颗粒，这些纳米颗粒在诊断成像中（如磁共振和X射线成像）中发挥作用，使用具有亲水基团的α-羟基膦酸共轭物处理，使纳米颗粒具有足够的亲水性以在诊断成像中发挥作用。公开的改性亲水性纳米颗粒包括那些改性共轭物的亲水基团为乙烯氧化物基聚合物和共聚物以及带电离子的纳米颗粒，这些纳米颗粒由过渡金属氧化物组成，如超顺磁性氧化铁和氧化钽。公开了足够亲水的纳米颗粒，以形成稳定的水性胶体悬浊液。还公开了使用改性亲水性纳米颗粒作为对比剂进行诊断成像，如磁共振和X射线成像。