phenyl(pyrazin-2-yl)methylamine | 724438-48-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: phenyl(pyrazin-2-yl)methylamine
• 英文别名: Phenyl(pyrazin-2-yl)methanamine
• CAS: 724438-48-6
• 化学式: C₁₁H₁₁N₃
• 分子量: 185.228
• InChiKey: YBJKKIWQRXZLLI-UHFFFAOYSA-N

物化性质

• 沸点：
  330.7±37.0 °C(Predicted)
• 密度：
  1.159±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenyl(pyrazin-2-yl)methylamine 在 magnesium sulfate 、 potassium carbonate 作用下， 以 甲醇 为溶剂， 生成 N-benzyl-N-methyl-1-phenyl-1-(pyrazin-2-yl)methanamine
  参考文献：
  名称：

  N-杂环吡啶甲基甲胺：合成，络合，分子结构及其在不对称铃木-宫浦和氧化偶联反应中的应用

  摘要：

  描述了基于π-缺陷的N-杂环吡啶基甲胺核的N，N-二齿配体的合成。说明了溶液和固态中相应的N，N-配体-钯配合物的制备和表征。Pd配合物在不对称的Suzuki-Miyaura偶联反应中显示出良好的收率和中等的催化活性（高达40％ee），从而导致了甲氧基双萘基衍生物。N，N-吡啶基甲胺与碘化亚铜的组合显示了氧化萘酚衍生物偶联反应中的有效催化体系，以高收率提供了相应的联萘，对映选择性高达61％。

  DOI：

  10.1021/om200375s
• 作为产物：
  描述：

  Phenyl-pyrazin-2-yl-methanone oxime 在 溶剂黄146 、 锌 、 水 、 碳酸氢钠 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 phenyl(pyrazin-2-yl)methylamine
  参考文献：
  名称：

  WO2008/85008

  摘要：

  公开号：

文献信息

• N‐Heterocyclic Benzhydrylamines as New <i>N</i> , <i>N</i> ‐Bidentate Ligands in Palladium Complexes: Synthesis, Characterization and Catalytic Activity
  作者：Vincent Terrasson、Damien Prim、Jérome Marrot

  DOI：10.1002/ejic.200800154

  日期：2008.6

  AbstractThe synthesis of new N,N‐bidentate ligands based on a π‐deficient N‐heterocyclic benzhydrylamine core is described. The corresponding air‐stable palladium complexes are obtained in high yields and fully characterized by NMR spectroscopy and X‐ray structure determination. These new phosphane‐free catalytic systems proved efficient in the Suzuki–Miyaura reaction, enabling us to obtain biaryl products in good yields, also for reactions with o‐substituted phenyl chlorides as starting materials. The effects of both electronic and steric modulations at the benzhydrylamine core on the catalytic activity are also described.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
• [EN] COMPOUND LIBRARIES OF IMIDAZO[1,5-A]PYRIDIN-3-YL DERIVATIVES AND RELATED HETEROBICYCLES FOR TARGETTING COMPOUNDS CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS<br/>[FR] BIBLIOTHEQUES DE COMPOSES
  申请人：BIOFOCUS PLC

  公开号：WO2004058755A2

  公开（公告）日：2004-07-15

  The present invention provides a library designed to take advantage of a common recognition feature of G-protein coupled receptors, namely the ‘benzhydryl’ or ‘rabbit ears’ arrangement of aromatic rings. In addition the library utilises several themes common in GPCRs selecting for subsets which recognise basic and ‘acidic’ ligands. The library comprises or consists of a set of structurally related compounds of general formulae (A)or (B). The present invention also provides intermediates (formula (3)).
• [EN] T-CELL INHIBITING COMPOUNDS AND THEIR USE FOR THE TREATMENT OF T-CELL-MEDIATED DISEASES<br/>[FR] COMPOSÉS INHIBANT LES LYMPHOCYTES T ET LEUR UTILISATION POUR LE TRAITEMENT DE MALADIES À MÉDIATION PAR LES LYMPHOCYTES T
  申请人：MOGAM BIOTECH RES INST

  公开号：WO2008085008A1

  公开（公告）日：2008-07-17

  [EN] The present invention relates to compounds of formula IA or IB. The present invention also concerned to a method of treating immunologic diseases or pathological conditions in association with T cell involving an immunologic component using T-cell inhibitors, optionally in combination with one or more other drugs selected from steroids, DMARDs, NSAIDs, immunosuppressive, and biological modifiers, pharmaceutical compositions comprising said compounds of formula IA or IB together with said other drugs, and the use of T-cell inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.
  [FR] La présente invention concerne des composés de formule IA ou IB. L'invention concerne également un procédé pour traiter des maladies immunologiques ou des états pathologiques associés aux lymphocytes T présentant une composante immunologique au moyen d'inhibiteurs des lymphocytes T, éventuellement en combinaison avec un ou plusieurs autres médicaments choisis parmi les stéroïdes, les ARMM, les AINS, les immunodépresseurs et les modificateurs biologiques, des compositions pharmaceutiques comprenant lesdits composés de formule IA ou IB en combinaison avec lesdits autres médicaments, ainsi que l'utilisation d'inhibiteurs des lymphocytes T pour fabriquer une composition pharmaceutique pour le traitement de maladies immunologiques ou d'états pathologiques à composante immunologique.
• N-Heterocyclic Pyridylmethylamines: Synthesis, Complexation, Molecular Structure, and Application to Asymmetric Suzuki–Miyaura and Oxidative Coupling Reactions
  作者：Guillaume Grach、Grégory Pieters、Aurelia Dinut、Vincent Terrasson、Raouf Medimagh、Alexandre Bridoux、Vanessa Razafimahaleo、Anne Gaucher、Sylvain Marque、Jérôme Marrot、Damien Prim、Richard Gil、José Giner Planas、Clara Viñas、Isabelle Thomas、Jean-Philippe Roblin、Yves Troin

  DOI：10.1021/om200375s

  日期：2011.8.8

  The synthesis of N,N-bidentate ligands based on a π-deficient N-heterocyclic pyridylmethylamine core is described. The preparation and characterization of the corresponding N,N-ligand–palladium complexes in solution and the solid state are illustrated. Pd complexes showed a good yield and moderate catalytic activity (up to 40% ee) in the asymmetric Suzuki–Miyaura coupling reaction, leading to methoxybinaphthyl

  描述了基于π-缺陷的N-杂环吡啶基甲胺核的N，N-二齿配体的合成。说明了溶液和固态中相应的N，N-配体-钯配合物的制备和表征。Pd配合物在不对称的Suzuki-Miyaura偶联反应中显示出良好的收率和中等的催化活性（高达40％ee），从而导致了甲氧基双萘基衍生物。N，N-吡啶基甲胺与碘化亚铜的组合显示了氧化萘酚衍生物偶联反应中的有效催化体系，以高收率提供了相应的联萘，对映选择性高达61％。
• WO2008/85008
  申请人：——

  公开号：——

  公开（公告）日：——