2-(5-甲基噻吩-2-基)吡咯烷 | 524674-41-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(5-甲基噻吩-2-基)吡咯烷
• 英文名称: 2-(5-Methylthiophen-2-yl)pyrrolidine
• CAS: 524674-41-7
• 化学式: C₉H₁₃NS
• mdl: MFCD05189302
• 分子量: 167.27
• InChiKey: WBJASOWBXMIUHI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  40.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BACE 2 INHIBITORS
  申请人：Mauser Harald

  公开号：US20120053200A1

  公开（公告）日：2012-03-01

  The present invention relates to N-1-Benzyl-2-hydroxy-3-(hetero)arylamino-propyl)-isophthalamides of formula I having BACE2 inhibitory activity and their use as therapeutically active substances, their manufacture and pharmaceutical compositions. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. type 2 diabetes.

  本发明涉及具有BACE2抑制活性的N-1-苄基-2-羟基-3-((杂)芳基)氨基丙基)-异苯二酰胺的公式I，以及它们作为治疗活性物质的用途、它们的制备和制药组合物。本发明的活性化合物在治疗和/或预防治疗例如2型糖尿病方面是有用的。
• [EN] BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES<br/>[FR] INHIBITEURS DE LA BACE POUR UNE UTILISATION DANS LE TRAITEMENT DU DIABÈTE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012028563A1

  公开（公告）日：2012-03-08

  The present invention relates to N-1-Benzyl-2-hydroxy-3-(hetero)arylamino-propyl)-isophthalamides of formula (I) having BACE2 inhibitory activity and their use as therapeutically active substances, their manufacture and pharmaceutical compositions. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. type 2 diabetes.

  本发明涉及具有BACE2抑制活性的式(I)的N-1-苄基-2-羟基-3-(杂)芳基氨基丙基异苯二酰胺，以及它们作为治疗活性物质的用途，它们的制造和药物组合物。本发明的活性化合物在治疗和/或预防治疗例如2型糖尿病方面是有用的。
• COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES
  申请人：Swann Steven L.

  公开号：US20090258907A1

  公开（公告）日：2009-10-15

  Disclosed herein are compounds of formula (I) or pharmaceutical acceptable salts thereof, wherein X, R 1 , R 2 , R 3 , R 4 , L 1 , and m, are defined in the specification. Compositions comprising said compounds which can be useful for inhibiting Rho kinase (ROCK) and methods for using said compositions are also described.

  本文披露了公式(I)的化合物或其药物可接受的盐，其中X、R1、R2、R3、R4、L1和m在规范中定义。还描述了包含所述化合物的组合物，其可以用于抑制Rho激酶（ROCK），以及使用所述组合物的方法。
• BACE INHIBITORS FOR USE IN THE TREATMENT OF DIABETES
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2611441A1

  公开（公告）日：2013-07-10
• [EN] 2-AMINO-BENZOTHIAZOLE DERIVATES USEFUL AS INHIBITORS OF ROCK KINASES<br/>[FR] DÉRIVÉS DE 2-AMINO-BENZOTHIAZOLE UTILES EN TANT QU'INHIBITEURS DES KINASES ROCK
  申请人：ABBOTT LAB

  公开号：WO2009126635A1

  公开（公告）日：2009-10-15

  Disclosed herein are compounds of formula (I) or pharmaceutical acceptable salts thereof, (I) wherein X, R1, R2, R3, R4, L1, and m, are defined in the specification. Compositions comprising said compounds which can be useful for inhibiting Rho kinase (ROCK) and methods for using said compositions are also described.