8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromene-2,6-dione 6-hydrazone | 1160228-27-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromene-2,6-dione 6-hydrazone
• 英文别名: 8,8,10-Trimethyl-4-phenyl-7,8-dihydropyrano[3,2-g]-chromene-2,6-dione 6-hydrazone；4-hydrazinylidene-2,2,10-trimethyl-6-phenyl-3H-pyrano[3,2-g]chromen-8-one
• CAS: 1160228-27-2
• 化学式: C₂₁H₂₀N₂O₃
• 分子量: 348.401
• InChiKey: JXXWAVJLDUFUIS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  73.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromene-2,6-dione 6-hydrazone 、 乙酸酐 在 吡啶 作用下， 以84%的产率得到N'-[8,8,10-trimethyl-2-oxo-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-6-ylidene]acetohydrazide
  参考文献：
  名称：

  Synthesis and NMR spectroscopy investigations of functionalized 8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromene-2,6-diones and their spirothiadiazole derivatives

  摘要：

  New functionalized derivatives of 8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]-chromene-2,6-dione - analogues of the natural compound graveolone - possessing hydrazine, hydroxylamine, and thiosemicarbazide residues were synthesized and their reactions with acetic anhydride were studied. The structure of the obtained compounds was confirmed by NMR spectroscopy.

  DOI：

  10.1007/s00706-008-0934-0
• 作为产物：
  描述：

  8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromene-2,6-dione 、 一水合肼 在 吡啶 作用下， 反应 1.0h， 以82%的产率得到8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromene-2,6-dione 6-hydrazone
  参考文献：
  名称：

  Synthesis and NMR spectroscopy investigations of functionalized 8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromene-2,6-diones and their spirothiadiazole derivatives

  摘要：

  New functionalized derivatives of 8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]-chromene-2,6-dione - analogues of the natural compound graveolone - possessing hydrazine, hydroxylamine, and thiosemicarbazide residues were synthesized and their reactions with acetic anhydride were studied. The structure of the obtained compounds was confirmed by NMR spectroscopy.

  DOI：

  10.1007/s00706-008-0934-0

文献信息

• Synthesis and NMR spectroscopy investigations of functionalized 8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]chromene-2,6-diones and their spirothiadiazole derivatives
  作者：Viktoria S. Moskvina、Olexander V. Turov、Volodymyr P. Khilya、Myroslav M. Garazd、Ulrich M. Groth

  DOI：10.1007/s00706-008-0934-0

  日期：2008.11

  New functionalized derivatives of 8,8,10-trimethyl-4-phenyl-7,8-dihydro-2H,6H-pyrano[3,2-g]-chromene-2,6-dione - analogues of the natural compound graveolone - possessing hydrazine, hydroxylamine, and thiosemicarbazide residues were synthesized and their reactions with acetic anhydride were studied. The structure of the obtained compounds was confirmed by NMR spectroscopy.