2-(丙-2-基氨基)丁烷-1-醇 | 51977-18-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-(丙-2-基氨基)丁烷-1-醇
• 英文名称: 2-isopropylamino-butan-1-ol
• 英文别名: 2-ethyl isopropylaminoethanol；2-(Propan-2-ylamino)butan-1-ol
• CAS: 51977-18-5
• 化学式: C₇H₁₇NO
• mdl: MFCD11163773
• 分子量: 131.218
• InChiKey: HHZREYAIWSZPGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  a-丙烯酸氯甲酯 、 2-(丙-2-基氨基)丁烷-1-醇 在 三乙胺 作用下， 以 苯 为溶剂， 反应 60.0h， 以86%的产率得到2-(β-N-isopropilamino)-ethoxy-4,5-benzo-1,3,2-dioxaphospholane
  参考文献：
  名称：

  Chlorocarbonyl rhodium(I) complexes with chiral catecholphosphitoamines

  摘要：

  The interaction of chiral catecholposphitoamines drop P N drop with [Rh(CO)(2)Cl](2) is studied. The structures of the complexes formed are discussed on the basis of IR, H-1, C-13, P-31 NMR and mass spectral data.

  DOI：

  10.1016/0022-328x(93)83297-9
• 作为产物：
  描述：

  2-氨基-1-丁醇 、 丙酮 在 乙醇 、 铂 作用下， 生成 2-(丙-2-基氨基)丁烷-1-醇
  参考文献：
  名称：

  Hancock; Cope, Journal of the American Chemical Society, 1944, vol. 66, p. 1740,1742

  摘要：

  DOI：

文献信息

• Proton magnetic resonance studies of compounds with bridgehead nitrogen atoms—XXVI
  作者：T.A. Crabb、M.J. Hall、R.O. Williams

  DOI：10.1016/s0040-4020(01)93494-5

  日期：1973.1

  3′-disubstituted, and 3,5-disubstitted perhydro-7a-methyloxazolo[3,4-c]oxazoles has been synthesised. Some indication of the predominant conformations of these systems and of the related perhydro-imidazo[1,5-c]thiazoles is obtainable from the magnitude of the geminal coupling constants of the methylene group protons situated between the heteroatoms.

  已经合成了一系列的3-单取代的，3,3'-二取代的和3,5-二取代的全氢-7a-甲基恶唑并[3,4- c ]恶唑。这些体系和相关的全氢咪唑并[1，5- c ]噻唑的主要构型的某些迹象可从位于杂原子之间的亚甲基质子的双键偶合常数的大小获得。
• Long-acting local subcutaneously-applied anesthetics and compositions
  申请人：Lewenstein; Evalina

  公开号：US04004025A1

  公开（公告）日：1977-01-18

  Novel compounds constituting esters of benzoic acids, selected from the group consisting of p-vinyl benzoic acid and p-ethynyl benzoic acid, with an aminoethanol selected from the group consisting of diethylaminoethanol and N-substituted aminoethanols. The esters have the formula ##STR1## where X is selected from the group consisting of ##STR2## or HC.tbd.C and each of R.sub.1 and R.sub.2 is selected from the group consisting of H, lower alkyls containing up to 6 carbon atoms and cycloalkyls. The novel compounds also include inorganic and organic acid salts of said esters. The novel compounds have a unique medicinal function as local subcutaneously-applied anesthetics which have a long-acting effect when administered without vasoconstrictors that heretofore have been used to prevent rapid dissipation of subcutaneously-applied local anesthetics. The invention also embraces compositions containing the compounds and the method of using the novel compounds and compositions as local long-acting subcutaneously-applied anesthetics.

  新型化合物包括苯甲酸酯，选自p-乙烯基苯甲酸和p-乙炔基苯甲酸，与氨基乙醇选自二乙胺基乙醇和N-取代氨基乙醇。酯类化合物的化学式为##STR1##其中X选自##STR2##或HC.tbd.C，R.sub.1和R.sub.2各自选自H，含有最多6个碳原子的低碳烷基和环烷基。该新型化合物还包括所述酯的无机和有机酸盐。这些新型化合物作为局部皮下应用麻醉剂具有独特的药用功能，当不使用迄今用于防止皮下应用局部麻醉剂快速消散的血管收缩剂时，具有长效作用。该发明还涵盖含有这些化合物和使用这些新型化合物和组合物作为局部长效皮下应用麻醉剂的方法。
• SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (SYK) INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150148327A1

  公开（公告）日：2015-05-28

  The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R cy , C y , and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

  本发明提供了以下公式（I）的某些取代吡啶或其药学上可接受的盐，其中R1，R2，R3，R4，Rcy，Cy和t如本文所定义。 本发明还提供了包含这种化合物的制药组合物，并且提供了使用这些化合物治疗由脾酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。
• SUBSTITUTED DIAZINE AND TRIAZINE SPLEEN TYROSINE KINEASE (SYK) INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150166486A1

  公开（公告）日：2015-06-18

  The invention provides certain substituted diazine and triazine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R cy , C y , and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.

  本发明提供了公式(I)（I）的某些取代的二嗪和三嗪化合物或其药学上可接受的盐，其中R1，R2，R3，R4，Rcy，Cy和t的定义如本文所述。本发明还提供包含这些化合物的制药组合物，以及使用这些化合物治疗由脾酪氨酸激酶（Syk）激酶介导的疾病或病症的方法。
• Thiochromeno[2,3-c]quinolin-12-one derivatives and their use as topoisomerase inhibitors
  申请人：National Defense Medical Center

  公开号：EP3002287A1

  公开（公告）日：2016-04-06

  The invention provides a series of novel thiochromeno[2,3-c] quinolin-12-one derivatives (I). Further, the invention also provides the preparation method and application of said derivatives, said application comprises: said derivatives with treating effective amount are prepared into pharmaceutical compositions for inhibition of topoisomerase type I and II, inhibition of cancer cell growth, further treating cancer.

  本发明提供了一系列新型硫代苯并[2,3-c]喹啉-12-酮衍生物（I）。进一步地，本发明还提供了所述衍生物的制备方法及应用，所述应用包括：将所述衍生物以处理有效量制备成药物组合物，用于抑制拓扑异构酶Ⅰ型和Ⅱ型，抑制癌细胞生长，进一步治疗癌症。