3-(4-methylphenyl)amino-4-nitrophenol | 488141-00-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(4-methylphenyl)amino-4-nitrophenol
• 英文别名: 3-(4-methylanilino)-4-nitrophenol
• CAS: 488141-00-0
• 化学式: C₁₃H₁₂N₂O₃
• 分子量: 244.25
• InChiKey: MPDKHDIOJJKLBX-UHFFFAOYSA-N

物化性质

• 沸点：
  423.2±40.0 °C(Predicted)
• 密度：
  1.341±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  78.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(4-methylphenyl)amino-4-nitrophenol 、 4-溴丁酸甲酯 生成 4-[3-(4-Methylphenyl)amino-4-nitrophenyl]oxybutyric Acid Methyl Ester
  参考文献：
  名称：

  1-Phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives

  摘要：

  本文介绍了新的苯并咪唑衍生物，它们的制备方法以及它们用于生产用于治疗和预防与微神经胶质细胞活化和T细胞介导的免疫性疾病相关的药物，以及含有新的苯并咪唑衍生物的制药制剂。

  公开号：

  US20030229085A1
• 作为产物：
  描述：

  3-氟-4-硝基苯酚 、 乙烷,三氯氟- 在 水 、 盐酸 、 乙酸乙酯 、 Sodium sulfate-III 作用下， 以 乙酸乙酯 为溶剂， 反应 6.0h， 生成 3-(4-methylphenyl)amino-4-nitrophenol
  参考文献：
  名称：

  1-phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives

  摘要：

  本文描述了新的苯并咪唑衍生物，它们的生产以及它们用于生产用于治疗和预防与小胶质细胞激活和T细胞介导的免疫性疾病相关的药物制剂，以及含有新苯并咪唑衍生物的药物制剂。

  公开号：

  US06962932B2

文献信息

• 1-Aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：——

  公开号：US20030125550A1

  公开（公告）日：2003-07-03

  The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R 1 , R 2 , R 3 , A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds. 1

  该发明涉及具有一般式I的新型苯并咪唑衍生物，其中基团R1、R2、R3、A、B、Y和Z的含义如描述和索赔中所示，这些化合物用于生产用于治疗和预防与微胶质细胞激活相关疾病的药物剂，以及含有这些化合物的药物制剂。
• 1-Phenyl-2-heteroaryl-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Blume Thorsten

  公开号：US20050267160A1

  公开（公告）日：2005-12-01

  New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.

  本文描述了新的苯并咪唑衍生物，它们的生产以及它们用于制备与微胶质细胞激活和T细胞介导的免疫性疾病有关的药物治疗和预防疾病的用途，以及包含新的苯并咪唑衍生物的制药制剂。
• 1-phenyl-2-heteroaryl-substituted benzimdazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Blume Thorsten

  公开号：US06962932B2

  公开（公告）日：2005-11-08

  New benzimidazole derivatives are described, their production and their use for the production of pharmaceutical agents for treatment and prevention of diseases that are associated with a microglia activation and T-cell-mediated immunological diseases, as well as pharmaceutical preparations that contain the new benzimidazole derivatives.

  本文描述了新的苯并咪唑衍生物，它们的生产以及它们用于生产用于治疗和预防与小胶质细胞激活和T细胞介导的免疫性疾病相关的药物制剂，以及含有新苯并咪唑衍生物的药物制剂。
• 1-aryl-2-N-, S- or O-substituted benzimidazole derivatives, their use for the production of pharmaceutical agents as well as pharmaceutical preparations that contain these derivatives
  申请人：Schering AG

  公开号：US07196202B2

  公开（公告）日：2007-03-27

  The invention relates to novel benzimidazole derivatives with general formula I, whereby radicals R1, R2, R3, A, B, Y and Z have the meanings that are indicated in the description and the claims, the use of these compounds for the production of a pharmaceutical agent for treatment and prevention of diseases associated with microglia activation as well as pharmaceutical preparations that contain these compounds

  本发明涉及一种具有一般式I的新型苯并咪唑衍生物，其中基团R1、R2、R3、A、B、Y和Z具有说明书和权利要求中所示的含义，这些化合物的用途是制备用于治疗和预防与小胶质细胞激活相关的疾病的药物制剂，以及包含这些化合物的制剂。
• BENZIMIDAZOLDERIVATE ZUR BEHANDLUNG VON MIT MIKROGLIA-AKTIVIERUNG ASSOZIIERTEN ERKRANKUNGEN WIE INFLAMMATORISCHE, ALLERGISCHE, INFEKTIÖSE ODER AUTOIMMUNE ERKRANKUNGEN
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：EP1404656B1

  公开（公告）日：2005-05-18