(RS)-benzyloxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetic acid ethyl ester | 372950-71-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (RS)-benzyloxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetic acid ethyl ester
• 英文别名: ethyl 2-phenylmethoxy-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)acetate
• CAS: 372950-71-5
• 化学式: C₂₅H₃₂O₃
• 分子量: 380.527
• InChiKey: YVRBLEGNAXPNBK-UHFFFAOYSA-N

物化性质

• 沸点：
  475.6±40.0 °C(predicted)
• 密度：
  1.037±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  ethyl 2-oxo-2-(1',2',3',4'-tetrahydro-1',1',4',4'-tetramethyl-6'-naphthalenyl)acetate 、 苄氧基三甲基硅烷 以to give 1.2 g of (RS)-benzyloxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetic acid ethyl ester as slightly yellow oil的产率得到(RS)-benzyloxy-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetic acid ethyl ester
  参考文献：
  名称：

  RAR selective retinoid agonists

  摘要：

  含有双环融合环的新化合物，其中一个是苯基官能团，通过脂肪链连接到环烷基或芳基官能团，以及其药物活性盐，可用作RAR选择性视黄酸受体激动剂。此外，这种视黄酸受体激动剂，特别是视黄酸受体&ggr; (RAR&ggr;) 选择性激动剂，可用于治疗肺气肿及相关肺部疾病，以及用于治疗和预防皮肤疾病，恶性和前恶性上皮病变，口腔、舌、喉、食管、膀胱、子宫颈和结肠粘膜的治疗和预防。

  公开号：

  US06603012B2

文献信息

• NEW GAMMA SELECTIVE RETINOIDS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1280757A2

  公开（公告）日：2003-02-05
• US6603012B2
  申请人：——

  公开号：US6603012B2

  公开（公告）日：2003-08-05
• [EN] NEW GAMMA SELECTIVE RETINOIDS<br/>[FR] NOUVEAUX RETINOIDES SELECTIFS GAMMA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2001083438A2

  公开（公告）日：2001-11-08

  New RAR selective retinoid agonists of formula (I) wherein the symbols are as defined in the specification, and pharmaceutically active salts of carboxylic acids of formula (I), further the invention relates to the use of such retinoic acid receptor agonists, particularly retinoic acid receptor η(RARη) selective agonists for the treatment of emphysema and associated pulmonary diseases, as well as for the therapy and prophylaxis of dermatological disorders, for the therapy and prophylaxis of malignant and premalignant epithelial lesions, tumours and precancerous changes of the mucous membrane in the mouth, tongue, larynx, oesophagus, bladder, cervix and colon.
• RAR selective retinoid agonists
  申请人：——

  公开号：US20020026060A1

  公开（公告）日：2002-02-28

  New compounds containing bicyclic fused rings, one of which being a phenyl moiety connected by an aliphatic chain to a cycloalkyl or aryl moiety, and pharmaceutically active salts thereof are useful as RAR selective retinoid agonists. Furthermore, such retinoic acid receptor agonists, particularly retinoic acid receptor &ggr; (RAR&ggr;) selective agonists, are useful for the treatment of emphysema and associated pulmonary diseases, as well as for the therapy and prophylaxis of dermatological disorders, for the therapy and prophylaxis of malignant and premalignant epithelial lesions, tumors and precancerous changes of the mucous membrane in the mouth, tongue, larynx, esophagus, bladder, cervix and colon.

  含有双环融合环的新化合物，其中之一是苯基团，通过脂肪链连接到环烷基或芳基团，以及其药用活性盐可用作RAR选择性视黄醇激动剂。此外，这种视黄酸受体激动剂，特别是视黄酸受体&ggr; (RAR&ggr;) 选择性激动剂，可用于治疗肺气肿和相关肺部疾病，以及治疗和预防皮肤疾病，治疗和预防恶性和前恶性上皮病变、肿瘤和粘膜的癌前变化，如口腔、舌头、喉、食道、膀胱、子宫颈和结肠。