N-Isobutyl homophthalimide | 20863-84-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: N-Isobutyl homophthalimide
• 英文别名: 2-isobutyl-4H-isoquinoline-1,3-dione；N-Isobutyl-homophthalimid；2-(2-methylpropyl)-4H-isoquinoline-1,3-dione
• CAS: 20863-84-7
• 化学式: C₁₃H₁₅NO₂
• mdl: MFCD19350656
• 分子量: 217.268
• InChiKey: JGPZYUQUOMALKZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.384
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-Isobutyl homophthalimide 在 盐酸 作用下， 以 乙醇 为溶剂， 生成 2-Isobutyl-1,3,4(2H)-isoquinolinetrione
  参考文献：
  名称：

  1,3,4(2H)-isoquinolinetrione herbicides: Novel redox mediators of photosystem I

  摘要：

  AbstractA series of 1,3,4(2H)‐isoquinolinetriones have been found to be fast‐acting post‐emergence herbicides, producing symptoms of desiccation. These redox‐active compounds are very potent stimulators of the light‐dependent consumption of oxygen at photosystem I in isolated chloroplasts. Pulse radiolysis studies on 2‐ethyl‐1,3,4(2H)‐isoquinolinetrione have shown it to have free‐radical properties which could enhance the generation of superoxide radicals in plants. Electrochemical studies further support a redox mediator mode of action for the series. The compounds were found to be unstable towards hydrolysis, and this was considered to be a major factor limiting the overall herbicidal effects. Other parameters, related to uptake and/or translocation, which may limit the full expression of the herbicidal activity of certain compounds, are discussed.

  DOI：

  10.1002/ps.2780440108

文献信息

• Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus
  申请人：Chen X. Kevin

  公开号：US20070093430A1

  公开（公告）日：2007-04-26

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
• US7173057B2
  申请人：——

  公开号：US7173057B2

  公开（公告）日：2007-02-06
• US7449447B2
  申请人：——

  公开号：US7449447B2

  公开（公告）日：2008-11-11
• US7619094B2
  申请人：——

  公开号：US7619094B2

  公开（公告）日：2009-11-17
• [EN] ISOQUINOLINETRIONE DERIVATIVES AS HERBICIDES<br/>[FR] DERIVES D'ISOQUINOLINETRIONE UTILISES COMME HERBICIDES
  申请人：ZENECA LIMITED

  公开号：WO1994027969A1

  公开（公告）日：1994-12-08

  (EN) A herbicidal composition comprising a compound of formula (I) or a salt thereof, where R1 is selected from hydrogen; optionally substituted alkyl; optionally substituted alkoxy; acyloxy; hydroxy; NR4R5 where R4 and R5 are independently hydrogen or alkyl; or optionally substituted aryl; R2 and R3 together form a fused optionally substituted 5 or 6-membered aromatic carbocyclic or heterocyclic ring; and X, Y and Z are independently selected from =C(CN)2, NOH, NOR6, NNR7R8, NCN or NR9 where R6, R7, and R8 are independently selected from hydrogen, optionally substituted alkyl, optionally substituted alkenyl and optionally substituted alkynyl and R9 is optionally substituted phenyl; in combination with a carrier or diluent.(FR) L'invention concerne une composition herbicide comprenant un composé de la formule (I) ou un sel de celui-ci, formule dans laquelle R1 est sélectionné parmi hydrogène; alkyle éventuellement substitué; alcoxy éventuellement substitué; acyloxy; hydroxy; NR4R5 où R4 et R5 représentent indépendamment hydrogène ou alkyle; ou aryle éventuellement substitué; R2 et R3 forment, réunis, un noyau aromatique carbocyclique ou hétérocyclique, condensé, pentagonal ou hexagonal, éventuellement substitué; et X, Y et Z sont indépendamment sélectionnés parmi = C(CN)2, NOH, NOR6, NNR7R8, NCN ou NR9, où R6, R7 et R8 sont indépendamment sélectionnés parmi hydrogène, alkyle éventuellement substitué, alcényle éventuellement substitué et alcynyle éventuellement substitué, et R9 représente phényle éventuellement substitué; en combinaison avec un excipient ou un diluant.