N-Methyl-N',N'-bis-(2-hydroxy-aethyl)-aethylendiamin | 52977-93-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-Methyl-N',N'-bis-(2-hydroxy-aethyl)-aethylendiamin
• 英文别名: 2-[2-Hydroxyethyl-[2-(methylamino)ethyl]amino]ethanol
• CAS: 52977-93-2
• 化学式: C₇H₁₈N₂O₂
• 分子量: 162.232
• InChiKey: WAIVAOHZBZDNEW-UHFFFAOYSA-N

物化性质

• 沸点：
  132-133 °C(Press: 0.9 Torr)
• 密度：
  1.045±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.7
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-N-甲基乙酰胺 、 二乙醇胺 生成 N-Methyl-N',N'-bis-(2-hydroxy-aethyl)-aethylendiamin
  参考文献：
  名称：

  Synthetic Schistosomicides. II. 1-[(Dialkylaminoalkyl)-methylamino]-4-methyl-10-thiaxanthenones¹

  摘要：

  DOI：

  10.1021/jo01066a052

文献信息

• Aminoalkylamide substituted cyclohexyl derivatives
  申请人：Ackermann Jean

  公开号：US20050065210A1

  公开（公告）日：2005-03-24

  The present invention relates to compounds of formula I wherein R 1 , R 2 , R 3 , R 4 , R 5 , U, V, W, k and m are as defined in the description and claims, and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

  本发明涉及式I的化合物 其中R 1 ，R 2 ，R 3 ，R 4 ，R 5 ，U，V，W，k和m如描述和权利要求中所定义，并且其药学上可接受的盐和/或药学上可接受的酯。这些化合物可用于治疗和/或预防与2,3-氧化齐墩果烷-鲍壳甾醇环化酶相关的疾病，如高胆固醇血症、高脂血症、动脉硬化、血管疾病、真菌病、寄生虫感染、胆结石、肿瘤和/或过度增殖性疾病，以及治疗和/或预防糖耐量受损和糖尿病。
• PYRIMIDINE COMPOUND
  申请人：Matsushima Yuji

  公开号：US20110053912A1

  公开（公告）日：2011-03-03

  A novel and excellent method for preventing and/or treating diseases related to a cannabinoid type 2 receptor, based on an agonistic action on a cannabinoid type 2 receptor. It was found that a hetero ring derivative mainly having two substituents, for example, a pyrimidine-5-carboxamide derivative having a substituent amino group at the 2-position, exhibits a potent agonistic action on a cannabinoid type 2 receptor, and can be an agent for preventing and/or treating diseases related to a cannabinoid type 2 receptor such as inflammatory diseases, pain, and the like.

  一种预防和/或治疗与大麻素2型受体相关疾病的新颖优秀方法，基于对大麻素2型受体的激动作用。发现一种异核环衍生物主要具有两个取代基，例如，在2-位置具有取代基氨基的嘧啶-5-羧酰胺衍生物，表现出对大麻素2型受体的强效激动作用，可以成为预防和/或治疗与大麻素2型受体相关疾病，如炎症性疾病、疼痛等的药物。
• ARYLMETHYLENE UREA DERIVATIVE AND USE THEREOF
  申请人：Ohno Michihiro

  公开号：US20100016319A1

  公开（公告）日：2010-01-21

  This invention relates to a pharmaceutical comprising as an effective ingredient an arylmethylene urea exemplified by the following formula: or a pharmaceutically acceptable salt thereof. The arylmethylene urea and the pharmaceutically acceptable salts thereof are useful for therapy or prophylaxis of inflammatory bowel disease and overactive bladder.

  本发明涉及一种药物，其有效成分为以下式子所示的芳基亚甲基脲或其药学上可接受的盐： 该芳基亚甲基脲及其药学上可接受的盐可用于治疗或预防炎症性肠病和过度活跃的膀胱。
• HETEROCYCLIC COMPOUND AND HEMATOPOIETIC STEM CELL AMPLIFIER
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2439204A1

  公开（公告）日：2012-04-11

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar1, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  本发明提供了一种造血干细胞和/或造血祖细胞扩增剂，用于提高基因治疗中基因转入造血干细胞的效率，以治疗各种疾病。 一种用于造血干细胞和/或造血祖细胞的扩增剂，含有由式（I）代表的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的同系物、原药或药学上可接受的盐或其溶液，可扩增造血干细胞和/或造血祖细胞。
• Further Investigations of Heterocyclic Alkylating Agents¹
  作者：Robert K. Preston、Richard M. Peck、Evelyn R. Breuninger、Ann J. Miller、Hugh J. Creech

  DOI：10.1021/jm00334a017

  日期：1964.7