2-(环丙基甲基)-苯酚 | 33494-47-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 2-(环丙基甲基)-苯酚
• 中文别名: 2-(环丙基甲基)苯酚
• 英文名称: 2-(cyclopropylmethyl)phenol
• CAS: 33494-47-2
• 化学式: C₁₀H₁₂O
• 分子量: 148.205
• InChiKey: OSSXBXCEVWBVFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2907199090

反应信息

• 作为反应物：
  描述：

  2-(环丙基甲基)-苯酚 在 palladium dichloride copper dichloride 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以64%的产率得到3-ethylbenzofuran
  参考文献：
  名称：

  钯催化的芳基环丙烷的氧化活化。

  摘要：

  电中性环丙烷衍生物的氯化钯催化的分子内活化导致环丙烷环的裂解，随后形成杂环衍生物。在该催化活化化学中，酚，羧酸和酰胺基被认为是环丙烷环邻位的取代基。在含酰胺的底物的情况下观察到的区域选择性与含羧酸的底物的区域选择性不同，排除了简单的环丙烷异构化，然后进行瓦克氧化作为机理途径。[反应：看文字]

  DOI：

  10.1021/ol062476e
• 作为产物：
  描述：

  烯丙基苯基醚 在 diethylzinc 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 10.5h， 生成 2-(环丙基甲基)-苯酚
  参考文献：
  名称：

  使用多任务单铑催化剂双异构化/环异构化/芳构化 1-（烯丙氧基）-2-（环丙基甲基）苯得到 2-乙基-3-异丙基苯并呋喃

  摘要：

  允许在单个反应容器内进行多种化学转化的多任务单催化剂系统对于生态相容性化学的发展非常重要。在这里，我们开发了一种铑催化系统，通过双异构化/环异构化/芳构化将 1-(烯丙氧基)-2-(环丙基甲基)苯衍生物转化为 2-乙基-3-异丙基苯并呋喃。

  DOI：

  10.1039/d1cc06163a

文献信息

• Unusual rearrangement of (cyclopropylmethoxy)benzene and its derivatives in the presence of BF3·Et2O
  作者：D. O. Ptashko、M. D. Khanova、V. A. Dokichev、Yu. V. Tomilov

  DOI：10.1134/s1070428011100071

  日期：2011.10

  (Cyclopropylmethoxy)benzene and its ortho- and para-bromo-substituted analogs in the presence of BF3 center dot Et2O undergo rearrangement with formation of (cyclobutyloxy)benzene and 2-ethyl-2,3-dihydro-1-benzofuran.

  在BF3·Et2O存在下，（环丙基甲氧基）苯及其邻位和对位溴代的类似物发生重排，生成（环丁氧基）苯和2-乙基-2,3-二氢-1-苯并呋喃。
• 3-phenoxy-4-pyridazinol derivatives and herbicide composition containing the same
  申请人：Tsukamoto Yoshihisa

  公开号：US20050037925A1

  公开（公告）日：2005-02-17

  A compound represented by the formula: [wherein R 1 represents a hydrogen atom, a halogen, atom, alkyl group, etc., R 2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 3 , R 4 , R 5 , R 6 and R 7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substituteable cycloalkyl group, etc., or R 3 , R 4 , R 5 , R 6 and R 7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.

  一种化合物由以下式子表示：[其中R1代表氢原子，卤素原子，烷基团等，R2代表氢原子，卤素原子，烷基团等，R3，R4，R5，R6和R7各自独立地代表氢原子，卤素原子，可替换的烷基团，可替换的烯基团，炔基团，可替换的环烷基团等，或R3，R4，R5，R6和R7可以形成一个环，该环可以被取代，该环由相邻的两个碳原子形成，这些碳原子与相应的取代基团相连，m和n各自独立地代表0或1。]其盐，酯衍生物及含有该化合物为有效成分的农药，以及含有该化合物和第二种草甘膦活性化合物为有效成分的除草剂组合物。
• 3-Phenoxy-4-pyridazinol derivatives and herbicidal composition containing the same
  申请人：Tsukamoto Yoshihisa

  公开号：US20100041555A1

  公开（公告）日：2010-02-18

  A compound represented by the formula: [wherein R 1 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 2 represents a hydrogen atom, a halogen atom, alkyl group, etc., R 3 , R 4 , R 5 , R 6 and R 7 each independently represent a hydrogen atom, a halogen atom, a substitutable alkyl group, a substitutable alkenyl group, alkynyl group, a substitutable cycloalkyl group, etc., or R 3 , R 4 , R 5 , R 6 and R 7 may form a ring which may be substituted, which is formed by the adjacent two of them with carbon atoms to which the respective substituents are bonded, m and n each independently represent 0 or 1.] a salt thereof, an ester derivative thereof and an agricultural chemical containing the same as an effective ingredient, and a herbicidal composition containing the compound and a second herbicidally active compound as effective ingredients.

  一种化合物，其化学式为：[其中R1代表氢原子、卤素原子、烷基等，R2代表氢原子、卤素原子、烷基等，R3、R4、R5、R6和R7各自独立地代表氢原子、卤素原子、可替换的烷基、可替换的烯基、炔基、可替换的环烷基等，或R3、R4、R5、R6和R7可形成一个环，该环可以被取代，由它们中的相邻两个碳原子形成，各自带有相应的取代基，m和n各自独立地代表0或1。]其盐、酯衍生物和含有该化合物作为有效成分的农药，以及含有该化合物和第二种除草活性化合物作为有效成分的除草剂组合物。
• 3-PHENOXY-4-PYRIDAZINOL DERIVATIVE AND HERBICIDE COMPOSITION CONTAINING THE SAME
  申请人：MITSUI CHEMICALS AGRO, INC.

  公开号：EP1426365B9

  公开（公告）日：2009-10-21
• Exploring Multitarget Interactions to Reduce Opiate Withdrawal Syndrome and Psychiatric Comorbidity
  作者：Fabio Del Bello、Eleonora Diamanti、Mario Giannella、Valerio Mammoli、Laura Mattioli、Federica Titomanlio、Alessandro Piergentili、Wilma Quaglia、Marco Lanza、Chiara Sabatini、Gianfranco Caselli、Elena Poggesi、Maria Pigini

  DOI：10.1021/ml400232p

  日期：2013.9.12

  Opioid addiction is often characterized as a chronic relapsing condition due to the severe somatic and behavioral signs, associated with depressive disorders, triggered by opiate withdrawal. Since prolonged abstinence remains a major challenge, our interest has been addressed to such objective. Exploring multitarget interactions, the present investigation suggests that 3 or its (S)-enantiomer and 4, endowed with effective alpha(2C)-AR agonism/alpha(2A)-AR antagonism/5-HT1A-R agonism, or 7 and 9-11 producing efficacious alpha(2C)-AR agonism/alpha(2A)-AR antagonism/I-2-IBS interaction might represent novel multifunctional tools potentially useful for reducing withdrawal syndrome and associated depression. Such agents, lacking in sedative side effects due to their alpha(2A)-AR antagonism, might afford an improvement over current therapies with clonidine-like drugs.